INTRODUCTION: Hypokinetic dysarthria (HD) is a common symptom of Parkinson's disease (PD) which does not respond well to PD treatments. We investigated acute effects of repetitive transcranial magnetic stimulation (rTMS) of the motor and auditory feedback area on HD in PD using acoustic analysis of speech. METHODS: We used 10 Hz and 1 Hz stimulation protocols and applied rTMS over the left orofacial primary motor area, the right superior temporal gyrus (STG), and over the vertex (a control stimulation site) in 16 PD patients with HD. A cross-over design was used. Stimulation sites and protocols were randomised across subjects and sessions. Acoustic analysis of a sentence reading task performed inside the MR scanner was used to evaluate rTMS-induced effects on motor speech. Acute fMRI changes due to rTMS were also analysed. RESULTS: The 1 Hz STG stimulation produced significant increases of the relative standard deviation of the 2nd formant (p = 0.019), i.e. an acoustic parameter describing the tongue and jaw movements. The effects were superior to the control site stimulation and were accompanied by increased resting state functional connectivity between the stimulated region and the right parahippocampal gyrus. The rTMS-induced acoustic changes were correlated with the reading task-related BOLD signal increases of the stimulated area (R = 0.654, p = 0.029). CONCLUSION: Our results demonstrate for the first time that low-frequency stimulation of the temporal auditory feedback area may improve articulation in PD and enhance functional connectivity between the STG and the cortical region involved in an overt speech control.
- MeSH
- akustika řeči MeSH
- dysartrie diagnostické zobrazování etiologie patofyziologie MeSH
- gyrus parahippocampalis diagnostické zobrazování patofyziologie MeSH
- konektom * MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- motorické korové centrum diagnostické zobrazování patofyziologie MeSH
- nervová síť diagnostické zobrazování patofyziologie MeSH
- Parkinsonova nemoc komplikace diagnostické zobrazování patofyziologie MeSH
- senioři MeSH
- senzorická zpětná vazba fyziologie MeSH
- spánkový lalok diagnostické zobrazování patofyziologie MeSH
- transkraniální magnetická stimulace * MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Recent findings indicate that complex cognitive functions are organized at a global level in the brain and rely on large-scale information processing requiring functional integration of multiple disparate neural assemblies. The critical question of the integration of distributed brain activities is whether the essential integrative role can be attributed to a specific structure in the brain or whether this ability is inherent to the cognitive network as a whole. The results of the present study show that mean values of the running correlation function in frontal-temporal EEG pairs with one electrode in the anterior cingulate cortex (ACC) are significantly higher than the same values in other frontal-temporal pairs. These findings indicate a particular role of the ACC in large-scale communication, which could reflect its unique integrative functions in cognitive processing.
- MeSH
- amygdala patofyziologie MeSH
- beta rytmus EEG fyziologie MeSH
- čelní lalok patofyziologie MeSH
- cingulární gyrus patofyziologie MeSH
- dominance mozková fyziologie MeSH
- elektroencefalografie MeSH
- epilepsie patofyziologie MeSH
- Fourierova analýza MeSH
- gyrus parahippocampalis patofyziologie MeSH
- hipokampus patofyziologie MeSH
- implantované elektrody MeSH
- korová synchronizace fyziologie MeSH
- lidé MeSH
- mapování mozku MeSH
- počítačové zpracování signálu MeSH
- spánkový lalok patofyziologie MeSH
- vědomí fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- financování organizované MeSH
- gyrus parahippocampalis patofyziologie MeSH
- lidé MeSH
- paměť MeSH
- schizofrenie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- srovnávací studie MeSH
