„Proteinase-activated“ receptor-2 (PAR-2) is a G protein-coupled transmembrane receptor with seven transmembrane domains activated by trypsin. It has been shown in the pancreatic tissue that PAR-2 is involved in duct/acinary cells secretion, arterial tonus regulation and capillary liquid content turnover under physiological conditions. These above mentioned structures play an important role during the development of acute pancreatitis and are profoundly influenced by a high concentration of trypsin enzyme after its secretion into the interstitial tissue from the basolateral aspect of acinar cells. Among the other factors, it is the increase of interstitial trypsin concentration followed rapidly by PAR-2 action on pancreatic vascular smooth muscle cells that initiates ischemic changes in pancreatic parenchyma and that finally leads to necrosis of the pancreas. Consequent reperfusion perpetuates changes leading to the acute pancreatitis development. On the contrary, PAR-2 action on both exocrine and duct structures seems to play locally a protective role during acute pancreatitis development. Moreover, PAR-2 action is not confined to the pancreas but it contributes to the systemic vascular endothelium and immune cell activation that triggers the systemic inflammatory response syndrome (SIRS) contributing to an early high mortality rate in severe disease.
- MeSH
- akutní nekrotizující pankreatitida enzymologie etiologie komplikace MeSH
- cévní endotel cytologie enzymologie patofyziologie MeSH
- lidé MeSH
- multiorgánové selhání etiologie komplikace MeSH
- receptor PAR-2 imunologie metabolismus MeSH
- syndrom systémové zánětlivé reakce enzymologie etiologie komplikace MeSH
- trypsin metabolismus sekrece škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- MeSH
- akutní nekrotizující pankreatitida diagnóza enzymologie krev MeSH
- albuminy izolace a purifikace MeSH
- biomedicínský výzkum MeSH
- chronická pankreatitida * diagnóza enzymologie krev MeSH
- elektroforéza na papíru * metody využití MeSH
- globuliny MeSH
- isoamylasa * izolace a purifikace krev MeSH
- lidé MeSH
- nemoci žlučových cest diagnóza enzymologie krev MeSH
- sérum MeSH
- statistika jako téma MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH