UNLABELLED: Background and aims. Patients with intrahepatic cholestasis of pregnancy (ICP) benefit from ursodeoxycholic acid (UDCA) treatment. Since there is still certain reluctance to use UDCA in pregnant women, mainly due to warnings in the official SPC information in respective drug leaflets, our objective was to assess the efficacy and safety of UDCA during pregnancy. MATERIAL AND METHODS: Our retrospective multicentric study was performed on 191 consecutive pregnant women with ICP treated with UDCA. Any maternal and/or fetal complications of the UDCA treatment were searched for; healthy pregnant women (n = 256) served as controls. RESULTS: The UDCA treatment improved liver disease status in the majority of the affected women (86.1%). This treatment was well tolerated, with only negligible skin reactions (0.5%) and mild diarrhea (4.7%). No complications attributable to UDCA treatment were detected during the fetal life, delivery, or the early neonatal period. CONCLUSION: We confirmed the good efficacy and safety of UDCA treatment in pregnancy for both mothers and fetuses/neonates.
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- MeSH
- cholagoga a choleretika škodlivé účinky terapeutické užití MeSH
- dospělí MeSH
- hodnocení rizik MeSH
- intrahepatální cholestáza * diagnóza farmakoterapie MeSH
- komplikace těhotenství diagnóza farmakoterapie MeSH
- kyselina ursodeoxycholová škodlivé účinky terapeutické užití MeSH
- lidé MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- těhotenství MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
15. akt. Aufl. 217 s. : il., tab. ; 21 cm
- MeSH
- biliární cirhóza farmakoterapie MeSH
- cholagoga a choleretika aplikace a dávkování farmakokinetika farmakologie škodlivé účinky terapeutické užití MeSH
- gastroezofageální reflux farmakoterapie MeSH
- kyselina deoxycholová analogy a deriváty aplikace a dávkování farmakokinetika farmakologie škodlivé účinky terapeutické užití MeSH
- žlučové kameny farmakoterapie MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Farmacie. Farmakologie
- NLK Obory
- gastroenterologie
- hepatologie
- farmacie a farmakologie
- farmakoterapie
