Úvod: Etiológia vzniku papilómov je multifaktoriálna. Existuje silná asociácia medzi ľudským papilomavírusom (HPV) a vývojom týchto spojovkových lézií. HPV je tumorogénny a bežne produkuje benígne nádory s nízkym potenciálom malígneho zvratu. Papilómy zriedkavo môžu prechádzať malígnou transformáciou. Materiál a metodika: Retrospektívna štúdia pacientov s diagnózou spojovkového papilómu alebo skvamocelulárneho karcinómu spojovky. Výsledky: V súbore 125 pacientov v období rokov 2007 - 2017 sme u spojovkových nepigmentovaných nádorov u 119 (95,2%) potvrdili histologickým vyšetrením papilóm a u 6 (4,8%) pacientov karcinóm. Z celkového počtu pacientov bolo 39 žien (31,2%) a 86 mužov (68,8%). Priemerný vek pacientov bol 68,4 rokov (rozsah 20 - 94 rokov). Lokalizácia lézií: bulbárna spojovka u 65 (52,0%), horná mihalnica tarzálna spojovka + fornix u 6 (4,8%), dolná mihalnica + fornix u 27 (21,6%), karunkula u 20 (16,0%) a plika semilunaris u 7 (5,6%) pacientov. V súbore pacientov sme zaznamenali 2 papilómy, ktoré sa transformovali do skamocelulárneho karcinómu. U pacientov bola HPV16 pozitivita, karcinómy vychádzali z oblasti bulbárnej spojovky, chirurgické riešenie bolo spojené s peroperačnou aplikáciou Mitomycínu C. V jednom prípade sa invertovaný papilóm do 2 rokov od primárnej excízie rozvinul do orbitálneho karcinómu a pacient následne absolvoval radikálne chirurgické riešenie (parciálna exenterácia očnice) s následnou rádioterapiou. Záver: Transformácia papilómu na karcinóm je zriedkavá, ale vždy na ňu treba myslieť pri recidíve ochorenia. HPV môže infikovať spojovku. Oftalmológ v spolupráci s patológom môže odporučiť vhodné laboratórne vyšetrenia na potvrdenie diagnózy. Ambulantné sledovanie pacientov po excízii papilómu spojovky je potrebné aj dlhodobe.
The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Papillomas rarely go through malignant transformation. Material and methods: Retrospective study of patients with a diagnosis of conjunctival papilloma or squamous cell carcinoma. Results: From a collection of 125 patients with conjunctival non-pigmented tumours in the period from 2007 to 2017, in 119 (95.2%) patients histological examination confirmed papilloma and in 6 (4.8%) patients it confirmed carcinoma. Of the total number of patients, 39 were women (31.2%) and 86 men (68.8%). The mean age of patients was 68.4 years (range 20-94 years). Localization of lesions: bulbar conjunctiva - 65 (52.0%), upper eyelid tarsal conjunctiva + fornix - 6 (4.8%), lower eyelid + fornix - 27 (21.6%), caruncle - 20 (16.0%) and plica semilunaris - 7 (5.6%) patients. In the patient cohort we recorded 2 papillomas that were transformed into squamous cell carcinoma. HPV16 was positive in these patients, the carcinomas were from the area of the bulbar conjunctiva, and the surgical solution was associated with the perioperative administration of Mitomycin C. In one case, the inverted papilloma developed into orbital carcinoma within 2 years of primary excision, and the patient underwent radical surgical procedure (partial exenteration of the orbit) followed by radiotherapy. Conclusion: Transformation of the papilloma into the carcinoma is rare, but it must always be taken into consideration in case of a recurrence of the disease. HPV can infect the conjunctiva. The ophthalmologist, in collaboration with a pathologist, may recommend appropriate laboratory tests to confirm the diagnosis. Long-term outpatient follow-up of patients after excision of the conjunctival papilloma is also necessary.
- MeSH
- infekce papilomavirem MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory spojivky * diagnóza etiologie MeSH
- papilom diagnóza etiologie MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
INTRODUCTION: The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Papillomas rarely go through malignant transformation. MATERIAL AND METHODS: Retrospective study of patients with a diagnosis of conjunctival papilloma or squamous cell carcinoma. RESULTS: In a collection of 125 patients in the period 2007–2017, 119 (95.2%) were confirmed by papilloma histological examination in 119 (95.2%) and in 6 (4.8%) patients with carcinoma. Of the total number of patients, 39 were women (31.2%) and 86 men (68.8%). The mean age of patients was 68.4 years (range 20–94 years). Localization of lesions: bulbar conjunctiva 65 (52.0%), upper eyelid tarsal conjunctiva + fornix 6 (4.8%), lower eyelid + fornix 27 (21.6%), caruncle 20 (16.0%) and plica semilunaris 7 (5.6%) patients. In the patient population we recorded 2 papillomas that were transformed into squamous cell carcinoma. HPV16 was positive in these patients, the carcinomas were from the area of the bulbar conjunctiva, and the surgical solution was associated with the perioperative administration of Mitomycin C. In one case, the inverted papilloma developed into orbital carcinoma within 2 years of primary excitement, and the patient underwent radical surgical procedure (partial exenteration of the orbit) followed by radiotherapy. CONCLUSION: Transformation of the papilloma into the carcinoma is rare, but it must always be thought of as a recurrence of the disease. HPV can infect the conjunctiva. The ophthalmologist, in collaboration with a pathologist, may recommend appropriate laboratory tests to confirm the diagnosis. Outpatient follow-up of patients after excision of the joint papilloma is also necessary.
- MeSH
- infekce papilomavirem komplikace patologie MeSH
- konjunktiva patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory spojivky * chirurgie diagnóza etiologie MeSH
- oční symptomy MeSH
- orbita patologie MeSH
- papilom diagnóza etiologie komplikace MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- spinocelulární karcinom diagnóza etiologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- MeSH
- lidé MeSH
- nádory choroidey diagnóza etiologie terapie MeSH
- nádory duhovky diagnóza etiologie terapie MeSH
- nádory očního víčka diagnóza etiologie terapie MeSH
- nádory oka diagnóza etiologie terapie MeSH
- nádory sítnice diagnóza etiologie terapie MeSH
- nádory spojivky diagnóza etiologie terapie MeSH
- nádory uvey diagnóza etiologie terapie MeSH
- Check Tag
- lidé MeSH
