free and cued verbal memory Dotaz Zobrazit nápovědu
BACKGROUND AND OBJECTIVE: Cognitive deficits in older adults attributable to Alzheimer's disease (AD) pathology are featured early on by hippocampal impairment. Among tests used to evaluate memory, verbal memory tests with controlled encoding and cued recall are believed to be specific for hippocampal impairment. The objective of this study was to assess the relation between left and right hippocampal volumes and several frequently used memory tests. METHODS: Fifty six nondemented older adults (30 with amnestic mild cognitive impairment and 26 cognitively healthy older adults) underwent neuropsychological testing including: (1) The Enhanced Cued Recall test (ECR), a memory test with controlled encoding and recall; (2) the Auditory Verbal Learning Test (AVLT), a verbal memory test without controlled encoding and with delayed recall; and (3) The Rey-Osterrieth Complex Figure test (ROCF), a visuospatial memory test-recall condition. 1.5T brain MRI scans were used to measure estimated total intracranial volume (eTIV) along with hippocampal right and left volumes, which were measured with quantitative volumetry using FreeSurfer package (version 4.4.0). Spearman partial correlation controlled for age was used to correct for non-normal score distribution and effect of age. RESULTS: We found moderate correlations of hippocampal volumes with AVLT 1-5 scores, AVLT delayed recall, ECR free and total recall, and ROCF reproduction. Total recall in ECR using cued recall was not superior to any of the free recall tests. No correlation in any memory test was achieved with eTIV. CONCLUSION: Verbal memory tests, either with controlled encoding and cued delayed recall (ECR), or without it (AVLT), as well as nonverbal memory test with delayed recall (ROCF), equally reflect hippocampal atrophy in nondemented older adults.
- MeSH
- atrofie patologie MeSH
- hipokampus patologie MeSH
- kognitivní poruchy komplikace patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- neuropsychologické testy MeSH
- počítačové zpracování obrazu MeSH
- poruchy paměti etiologie MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stárnutí patologie MeSH
- verbální učení fyziologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Innovative memory paradigms have been introduced to capture subtle memory changes in early Alzheimer's disease (AD). We aimed to examine the associations between different indexes of the challenging Memory Binding Test (MBT) and hippocampal volume (HV) in a sample of individuals with subjective cognitive decline (SCD; n = 50), amnestic mild cognitive impairment (aMCI) due to AD (n = 31), and cognitively normal (CN) older adults (n = 29) recruited from the Czech Brain Aging Study, in contrast to traditional verbal memory tests. Both MBT free and cued recall scores in immediate and delayed recall conditions were associated with lower HV in both SCD and aMCI due to AD, whereas in traditional verbal memory tests only delayed recall scores were associated with lower HV. In SCD, the associations with lower HV in the immediate recall covered specific cued recall indexes only. In conclusion, the MBT is a promising test for detecting subtle hippocampal-associated memory decline during the predementia continuum.
- MeSH
- demence * diagnóza MeSH
- hipokampus MeSH
- kognice MeSH
- krátkodobá paměť MeSH
- lidé MeSH
- rozpomínání * MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVE: The present study aims to examine whether declarative memory dysfunction relates to impaired core memory mechanisms or attentional and executive dysfunction in idiopathic REM Sleep Behavior Disorder (iRBD). METHOD: In this observational, cross-sectional study, were enrolled 82 individuals with the diagnosis of iRBD according to the International Classification of Sleep Disorders and 49-matched healthy controls fulfilling inclusion criteria. All participants underwent two memory tasks, namely the Rey Auditory Verbal Learning Test (RAVLT) and Memory Binding Test (MBT), which include conditions of varying degrees of dependence on executive functioning, as well as different indicators of core memory processes (e.g., learning, retention, relational binding). RESULTS: We used Bayesian multivariate generalized linear model analysis to evaluate the effect of iRBD on memory performance controlled for effects of age and sex. Individuals with iRBD displayed worse memory performance in the delayed free recall task (b = -0.37, 95% PPI [-0.69, -0.05]), but not on delayed recognition of the same material. Their performance in cued recall tasks both in immediate and delayed conditions was in comparison to controls relatively spared. Moreover, the deficit in delayed free recall was mediated by attention/processing speed. CONCLUSIONS: In iRBD, we replicated findings of reduced free recall based on inefficient retrieval (retrieval deficit), which was small in terms of effect size. Importantly, the memory profile across measures does not support the presence of core memory dysfunction, such as poor learning, retention or associative binding.
Cíl. Cílem této studie je přiblížit kontrolované učení a jeho zásadní roli ve vyšetření paměti a dále poskytnout české normy pro Test kontrolovaného učení s bezprostředním vybavením (FCSRT-IR) pro starší populaci. Soubor. Normativní soubor čítal 362 starších osob ve věku 62 let a více (průměrný věk = 73,5 roku; SD = 8,6; průměrný počet let vzdělání = = 13,1; SD = 3,5), kteří splnili anamnestická i výkonová kritéria kognitivně zdravých jedinců. Všem byl v rámci neuropsychologické baterie administrován test FCSRT-IR. Analýzy a výsledky. Byla zjištěna souvislost výkonu v FCSRT-IR s věkem (Spearman r = -0,2; p < 0,001), ale nikoli s pohlavím či vzděláním. Normativní údaje jsou proto poskytnuty pro dvě věkové kategorie, mladší (do 74 let) a starší senioři (75 a více let). Dále byla u obou věkových skupin ověřena rostoucí křivka učení, tedy zlepšení ve volném vybavení ve třech za sebou jdoucích pokusech FCSRT-IR.
Objectives. The goal of this study is to describe the controlled learning and its important role in memory assessment and provide Czech norms for Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR) for older adults. Sample and setting. The normative sample consisted of 362 older adults at the age of 62 and more (mean age=73,5; SD=8,6; mean years of education = 13,1; SD=3,5) who met the anamnestic and performance criteria of cognitively health population. They were administered Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR). Analysis and results. It was found that performance in FCSRT-IR is related to age (Spearman r = -0,2; p<0,001) but not to gender or education. Normative scores are provided separately for two age groups: younger (60–74) and older adults (75 plus older). The study confirmed that the learning slope increases what in this case means improvement in free recall in all three trials of FCSRT-IR.
- Klíčová slova
- FCSRT-IR,
- MeSH
- epizodická paměť MeSH
- interpretace statistických dat MeSH
- lidé MeSH
- longitudinální studie MeSH
- neuropsychologické testy MeSH
- poruchy paměti MeSH
- senioři * MeSH
- testy paměti a učení * MeSH
- učení * MeSH
- Check Tag
- lidé MeSH
- senioři * MeSH
- Publikační typ
- práce podpořená grantem MeSH
INTRODUCTION: A rapid and reliable neuropsychological protocol is essential for the efficient assessment of neurocognitive constructs related to emergent neurodegenerative diseases. We developed an AI-assisted, digitally administered/scored neuropsychological protocol that can be remotely administered in ~10 min. This protocol assesses the requisite neurocognitive constructs associated with emergent neurodegenerative illnesses. METHODS: The protocol was administered to 77 ambulatory care/memory clinic patients (56.40% women; 88.50% Caucasian). The protocol includes a 6-word version of the Philadelphia (repeatable) Verbal Learning Test [P(r)VLT], three trials of 5 digits backward from the Backwards Digit Span Test (BDST), and the "animal" fluency test. The protocol provides a comprehensive set of traditional "core" measures that are typically obtained through paper-and-pencil tests (i.e., serial list learning, immediate and delayed free recall, recognition hits, percent correct serial order backward digit span, and "animal" fluency output). Additionally, the protocol includes variables that quantify errors and detail the processes used in administering the tests. It also features two separate, norm-referenced summary scores specifically designed to measure executive control and memory. RESULTS: Using four core measures, we used cluster analysis to classify participants into four groups: cognitively unimpaired (CU; n = 23), amnestic mild cognitive impairment (MCI; n = 17), dysexecutive MCI (n = 23), and dementia (n = 14). Subsequent analyses of error and process variables operationally defined key features of amnesia (i.e., rapid forgetting, extra-list intrusions, profligate responding to recognition foils); key features underlying reduced executive abilities (i.e., BDST items and dysexecutive errors); and the strength of the semantic association between successive responses on the "animal" fluency test. Executive and memory index scores effectively distinguished between all four groups. There was over 90% agreement between how cluster analysis of digitally obtained measures classified patients compared to classification using a traditional comprehensive neuropsychological protocol. The correlations between digitally obtained outcome variables and analogous paper/pencil measures were robust. DISCUSSION: The digitally administered protocol demonstrated a capacity to identify patterns of impaired performance and classification similar to those observed with standard paper/pencil neuropsychological tests. The inclusion of both core measures and detailed error/process variables suggests that this protocol can detect subtle, nuanced signs of early emergent neurodegenerative illness efficiently and comprehensively.
- Publikační typ
- časopisecké články MeSH
