Context: Patients with Turner syndrome (TS) are at risk for osteoporotic fractures. Objective: The aims of this study were to assess the incidence of clinically important fractures in girls with TS and prospectively describe the development of volumetric bone mineral density (BMD). Design: Peripheral quantitative computerized tomography (pQCT) of the radius every other year over the 6 years of observation. Setting: Government-funded university referral center. Participants: Thirty-two girls with TS, aged 6 to 16 years, were included in the analyses. Fracture incidence was compared with the data in the general population. Bone density and strength were compared with data from 185 healthy girls. Outcomes: The main clinical outcome was the fracture occurrence. The secondary outcomes were the changes in Z-scores of the bone parameters. Results: Three girls with TS sustained four fractures during 6 years of observation. The fracture rate in TS was not substantially higher than the downward-biased fracture-rate estimate from age-matched, healthy controls (P = 0.48). Whereas the trabecular BMD Z-score decreased with age (β estimate -0.21 ± 0.04, P < 0.001), total bone cross-sectional area correspondingly increased (+0.16 ± 0.04, P < 0.001), which led to normal bone strength. A positive history of incident fractures was not significantly associated with any of the pQCT-derived bone parameters. Conclusions: Current pediatric TS patients that are treated with growth hormone and estrogens are not at risk for osteoporotic fractures. Low BMD in TS may be counterweighted by enlarged bone radius, which leads to normal bone strength at the appendicular skeleton.
- MeSH
- časové faktory MeSH
- dítě MeSH
- estrogeny terapeutické užití MeSH
- incidence MeSH
- kostní denzita účinky léků MeSH
- lidé MeSH
- mladiství MeSH
- následné studie MeSH
- osteoporotické fraktury epidemiologie etiologie MeSH
- počítačová rentgenová tomografie metody MeSH
- radius diagnostické zobrazování MeSH
- rizikové faktory MeSH
- růstový hormon terapeutické užití MeSH
- Turnerův syndrom komplikace farmakoterapie patofyziologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
3. vyd. 815 s. : il.
- Klíčová slova
- dětské lékařství,
- MeSH
- diferenciální diagnóza MeSH
- pediatrie MeSH
- NLK Obory
- pediatrie
- diagnostika
GeNeSIS. Next step for growth.
vii, 85 stran : ilustrace, grafy, tabulky ; 24 cm
The guide focuses on growth hormone deficiency in children and on its treatment, including the GeNeSIS research programme. Intended for professional public.
- MeSH
- hormonální substituční terapie MeSH
- hypofyzární nanismus genetika terapie MeSH
- klinická studie jako téma MeSH
- lékařská genetika MeSH
- lidský růstový hormon genetika terapeutické užití MeSH
- mutace genetika MeSH
- neuroendokrinologie MeSH
- růst a vývoj genetika MeSH
- vývojové poruchy u dětí genetika terapie MeSH
- Publikační typ
- příručky MeSH
Excerpta medica. International congress series. 1105
IX, 304 s. : obr., tab., grafy ; 24 cm
