- Keywords
- HRTF,
- MeSH
- Models, Anatomic MeSH
- Echolocation physiology MeSH
- Humans MeSH
- Sound Localization physiology MeSH
- Prospective Studies MeSH
- Auditory Pathways MeSH
- Auditory Perception * physiology MeSH
- Auditory Cortex physiology MeSH
- Models, Theoretical * MeSH
- Virtual Reality MeSH
- Sound MeSH
- Sound Spectrography methods instrumentation utilization MeSH
- Check Tag
- Humans MeSH
BACKGROUND: Small aggregates (oligomers) of the toxic proteins amyloid-β (Aβ) and phospho-tau (p-tau) are essential contributors to Alzheimer's disease (AD). In mouse models for AD or human AD brain extracts, Transcranial Electromagnetic Treatment (TEMT) disaggregates both Aβ and p-tau oligomers, and induces brain mitochondrial enhancement. These apparent "disease-modifying" actions of TEMT both prevent and reverse memory impairment in AD transgenic mice. OBJECTIVE: To evaluate the safety and initial clinical efficacy of TEMT against AD, a comprehensive open-label clinical trial was performed. METHODS: Eight mild/moderate AD patients were treated with TEMT in-home by their caregivers for 2 months utilizing a unique head device. TEMT was given for two 1-hour periods each day, with subjects primarily evaluated at baseline, end-of-treatment, and 2 weeks following treatment completion. RESULTS: No deleterious behavioral effects, discomfort, or physiologic changes resulted from 2 months of TEMT, as well as no evidence of tumor or microhemorrhage induction. TEMT induced clinically important and statistically significant improvements in ADAS-cog, as well as in the Rey AVLT. TEMT also produced increases in cerebrospinal fluid (CSF) levels of soluble Aβ1-40 and Aβ1-42, cognition-related changes in CSF oligomeric Aβ, a decreased CSF p-tau/Aβ1-42 ratio, and reduced levels of oligomeric Aβ in plasma. Pre- versus post-treatment FDG-PET brain scans revealed stable cerebral glucose utilization, with several subjects exhibiting enhanced glucose utilization. Evaluation of diffusion tensor imaging (fractional anisotropy) scans in individual subjects provided support for TEMT-induced increases in functional connectivity within the cognitively-important cingulate cortex/cingulum. CONCLUSION: TEMT administration to AD subjects appears to be safe, while providing cognitive enhancement, changes to CSF/blood AD markers, and evidence of stable/enhanced brain connectivity.
- MeSH
- Alzheimer Disease diagnostic imaging metabolism psychology therapy MeSH
- Amyloid beta-Peptides blood cerebrospinal fluid MeSH
- Cognition MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Neuropsychological Tests MeSH
- Neuroimaging MeSH
- tau Proteins blood cerebrospinal fluid MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Transcranial Magnetic Stimulation adverse effects methods MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
... The Enioanatomy of Function-Sustaining Chakras 230 -- 4.1. ... ... Function-sustaining chakra 262 -- Fig. 5. ... ... states of chakra cones -- Structure-functional states of chakra cones -- Different types of structure-functional ... ... of structure-functional states of chakra cones -- Topographic-functional states of chakra cone petals ... ... -- Function-sustaining chakras of the physical body\'s regions (front view) -- Function-sustaining chakras ...
1st ed. 318 s. : il., tab. ; 29 cm
- Keywords
- čakry,
- MeSH
- Anatomy, Cross-Sectional MeSH
- Anatomy, Regional MeSH
- Classification MeSH
- Mind-Body Relations, Metaphysical MeSH
- Parapsychology MeSH
- Energy Transfer MeSH
- Visible Human Projects MeSH
- Publication type
- Monograph MeSH
- Conspectus
- Anatomie člověka a srovnávací anatomie
- NML Fields
- anatomie
- psychologie, klinická psychologie
... Production, 14 -- Characteristic X-Rays and Auger Electrons, 16 Stopping Power and Linear Energy Transfer ... ... and Phil Sharpe -- Introduction, 152 Patient Immobilisation, 153 Thermoplastic Shells, 153 Patient Head ... ... Physical Simulation, 156 Computed Tomography Simulation, 157 Virtual Simulation, 157 -- A Typical Head ... ... Technique, 313 Conformal Radiotherapy, 313 Intensity Modulated and Image Guided -- Radiotherapy in Head ... ... and Fractionation, 317 Definitive Radiotherapy, 317 Postoperative Radiotherapy, 318 Chemotherapy in Head ...
Eighth edition xxiii, 615 stran : ilustrace, tabulky ; 28 cm
- MeSH
- Neoplasms radiotherapy MeSH
- Nuclear Medicine methods MeSH
- Radiotherapy methods MeSH
- Publication type
- Textbook MeSH
- Conspectus
- Učební osnovy. Vyučovací předměty. Učebnice
- Lékařské vědy. Lékařství
- NML Fields
- radiologie, nukleární medicína a zobrazovací metody
- onkologie
- NML Publication type
- kolektivní monografie
... Found in Proteins 112 -- TABLE 3-3 Some Molecules Covalently Attached to Proteins Regulate Protein Function ...
... and Archaea Have 1000-6000 Genes -re Generated from Preexisting Genes -- Give Rise to Families of Related ...
... from Its Sequence 2X Gene Families Are Common to All Three Primary of the Tree of Life -e.eal the Functions ...
... Protein Kinases and Protein Phosphatases 154 -- The Regulation of the Src =^zxBr
Sixth edition xxxiv, 1430 stran v různém stránkování : ilustrace (převážně barevné) ; 29 cm
- MeSH
- Cells * MeSH
- Molecular Biology MeSH
- Conspectus
- Biochemie. Molekulární biologie. Biofyzika
- NML Fields
- molekulární biologie, molekulární medicína
- NML Publication type
- učebnice vysokých škol
... All People -- 7 Community Health -- 8 Introduction to Microbiology -- Unit 3 Development of the Individual ... ... These chapters or units later in the book relate to subject matter in this chapter. ♦ Key Resources. ... ... A list of agencies for your reference when working with individuals and families. Key Concepts. ... ... , Neck, and Back -- Injuries 345 -- Cold-Related Injuries 345 -- Frostbite 345, Hypothermia 345 -- Heat-Related ... ... 1048, Tests of Parathyroid -- Function 1049, Tests of Adrenal Function 1050, Tests of -- General Pancreatic ...
6th ed. xlvi, 1518 s., I-52 : il.
... 121 -- 124 -- List of Topics xi -- There Are Limits to Self-assembly 126 -- Summary 127 -- Protein Function ... ... - Freeze-Fracture and Freeze-Etch Electron Microscopy -- Provide Novel Views of the Cell 152 -- Individual ... ... Bilayers Are Impermeable to Ions But Freely Permeable to Water Membrane-bound Transport Proteins Transfer ... ... 421 -- The Export of RNA from the Nucleus Requires Molecular Signals 422 -- Ribosomal RNAs and Transfer ... ... Bind to Actin Filaments 555 -- Myosin Heads “Walk” Along Actin Filaments 556 -- Actin and Myosin Are ...
xxxix, 1146 s. : il., tab. ; 28 cm
- MeSH
- Cell Biology MeSH
- Molecular Biology MeSH
- Publication type
- Monograph MeSH
- Conspectus
- Biochemie. Molekulární biologie. Biofyzika
- NML Fields
- biologie
- cytologie, klinická cytologie
... - And Organization 3 -- Signaling in Simple Neuronal Circuits 4 -- Complex Neuronal Circuitry in Relation ... ... to Higher -- Functions 4 -- Organization of the Retina 5 -- Shapes and Connections of Neurons 5 -- Cell ... ... Neurons and Tracing Their -- Connections 8 -- Nonneuronal Cells 8 -- Grouping of Cells According to Function ... ... 8 -- Subtypes of Cells in Relation to Function 9 -- Convergence and Divergence of Connections 9 -- Signaling ... ... Open Questions 575 -- Cellular and Molecular Studies of Neuronal Functions -- 576 -- Functional Importance ...
4th ed. XIX,580,A-8,B-5,C-8,G-7,BB-60,I-10 : obr.,tab.,grafy.
... | Protein Function 78 -- Specific Binding of Ligands Underlies the -- Functions of Most Proteins 78 - ... ... to Their Functions 118 -- I Transcription of Protein-Coding Genes and Formation of Functional mRNA 120 ... ... Domains and Promote Transcription 288 -- Repressors Inhibit Transcription and Are the -- Functional ... ... | Processing of rRNA and tRNA 358 -- Pre-rRNA Genes Function as Nucleolar Organizers and Are Similar ... ... Changes in the Myosin Head -- Couple ATP Hydrolysis to Movement 736 -- Myosin Heads Take Discrete Steps ...
6th ed. xxxvii, 1150 s. : il., tab. ; 29 cm
- MeSH
- Cell Biology MeSH
- Molecular Biology MeSH
- Publication type
- Monograph MeSH
- Conspectus
- Biochemie. Molekulární biologie. Biofyzika
- NML Fields
- biologie
- cytologie, klinická cytologie
