• MeSH
• biochemie MeSH
• biotechnologie MeSH

• Konspekt
• Chemický průmysl. Chemická technologie
• NLK Obory
• biomedicínské inženýrství
• biochemie
• NLK Publikační typ
• elektronické časopisy

Steroid sulfatase (EC 3.1.6.2) is an important enzyme involved in steroid hormone metabolism. It catalyzes the hydrolysis of steroid sulfates into their unconjugated forms. This action rapidly changes their physiological and biochemical properties, especially in brain and neural tissue. As a result, any imbalance in steroid sulfatase activity may remarkably influence physiological levels of active steroid hormones with serious consequences. Despite that the structure of the enzyme has been completely resolved there is still not enough information about the regulation of its expression and action in various tissues. In the past few years research into the enzyme properties and regulations has been strongly driven by the discovery of its putative role in the indirect stimulation of the growth of hormone-dependent tumors of the breast and prostate.

• Klíčová slova
• Steroid sulfatase, Enyzme, Sulfate, Physiological role, Action,
• MeSH
• cholesterol metabolismus   MeSH
• financování organizované MeSH
• hydrolýza MeSH
• lidé MeSH
• mozek enzymologie   MeSH
• nervová tkáň enzymologie   MeSH
• pohlavní steroidní hormony metabolismus   MeSH
• regulace genové exprese enzymů MeSH
• steryl-sulfatasa genetika   metabolismus   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH