CONTEXT: In men with prostate cancer (PCa) treated with curative intent, controversy exists regarding the impact of biochemical recurrence (BCR) on oncological outcomes. OBJECTIVE: To perform a systematic review of the existing literature on BCR after treatment with curative intent for nonmetastatic PCa. Objective 1 is to investigate whether oncological outcomes differ between patients with or without BCR. Objective 2 is to study which clinical factors and tumor features in patients with BCR have an independent prognostic impact on oncological outcomes. EVIDENCE ACQUISITION: Medline, Medline In-Process, Embase, and the Cochrane Central Register of Controlled Trials were searched. For objective 1, prospective and retrospective studies comparing survival outcomes of patients with or without BCR following radical prostatectomy (RP) or radical radiotherapy (RT) were included. For objective 2, all studies with at least 100 participants and reporting on prognostic patient and tumor characteristics in patients with BCR were included. Risk-of-bias and confounding assessments were performed according to the Quality in Prognosis Studies tool. Both a narrative synthesis and a meta-analysis were undertaken. EVIDENCE SYNTHESIS: Overall, 77 studies were included for analysis, of which 14 addressed objective 1, recruiting 20 406 patients. Objective 2 was addressed by 71 studies with 29 057, 11 301, and 4272 patients undergoing RP, RT, and a mixed population (mix of patients undergoing RP or RT as primary treatment), respectively. There was a low risk of bias for study participation, confounders, and statistical analysis. For most studies, attrition bias, and prognostic and outcome measurements were not clearly reported. BCR was associated with worse survival rates, mainly in patients with short prostate-specific antigen doubling time (PSA-DT) and a high final Gleason score after RP, or a short interval to biochemical failure (IBF) after RT and a high biopsy Gleason score. CONCLUSIONS: BCR has an impact on survival, but this effect appears to be limited to a subgroup of patients with specific clinical risk factors. Short PSA-DT and a high final Gleason score after RP, and a short IBF after RT and a high biopsy Gleason score are the main factors that have a negative impact on survival. These factors may form the basis of new BCR risk stratification (European Association of Urology BCR Risk Groups), which needs to be validated formally. PATIENT SUMMARY: This review looks at the risk of death in men who shows rising prostate-specific antigen (PSA) in the blood test performed after curative surgery or radiotherapy. For many men, rising PSA does not mean that they are at a high risk of death from prostate cancer in the longer term. Men with PSA that rises shortly after they were treated with radiotherapy or rapidly rising PSA after surgery and a high tumor grade for both treatment modalities are at the highest risk of death. These factors may form the basis of new risk stratification (European Association of Urology biochemical recurrence Risk Groups), which needs to be validated formally.

• MeSH
• kalikreiny krev   MeSH
• lidé MeSH
• lokální recidiva nádoru krev   mortalita   MeSH
• míra přežití MeSH
• nádory prostaty krev   mortalita   MeSH
• prognóza MeSH
• prostatický specifický antigen krev   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• systematický přehled MeSH

Popisujeme tři případy leiomyomu zažívacího traktu s inkluzními tělísky podobnými inkluzím vy- skytujícím se u infantilní digitální fibromatózy. První dva případy jsou leiomyomy žaludku, v obou těchto případech byla tělíska přítomna ve velkém množství. Ve třetím případu jde o leiomyom jíc- nu s výskytem pouze ojedinělých tělísek. Imunohistochemické vyšetření prokázalo ve všech pří- padech pozitivitu buněk leiomyomu s protilátkou proti aktinu HHF35, α -aktinu, h-caldesmonu a dezminu. Inkluzní tělíska byla v prvním případu fokálně pozitivní při průkazu cytokeratinů CAM 5.2 a CK 18. Ve druhém případu vykazovala tělíska periferní pozitivitu s protilátkou proti α -aktinu a aktinu HHF 35. Ve třetím případu byla tělíska zcela negativní. Elektronmikroskopické vyšetření jsme vzhledem k nedostatku materiálu provedli pouze u prvního případu. Ultrastrukturálně byla tělíska tvořena agregáty filament, v některých se zavzatými cytoplazmatickými organelami.

We report three cases of leiomyoma of the gastrointestinal tract with intracytoplasmic inclusion bodies similar to those characteristic of inclusion body fibromatosis (IBF). The first two cases represent leiomyoma of the stomach: one in a 70-year-old female and the other in a 72-year-old female. In both instances inclusion bodies were present in a large amount. In the third case the leiomyoma was located in the esophagus of a 63-year-old male and inclusion bodies in this case were rare. In all three cases an immunohistochemical analysis showed positivity of the tumor cells for muscle specific actin HHF35 (MSA), α -smooth muscle actin (SMA), h-caldesmon and desmin. The first case showed some inclusion bodies with positivity for cytokeratin CAM 5.2 and focal weak positivity for cytokeratin 18. In the second case the inclusion bodies were positive at the periphery with antibodies directed against MSA and SMA. In the third case the inclusion bodies were immunohistochemically entirely negative. Ultrastructurally, the inclusion bodies in the first case were composed of aggregated filaments, some with entrapped cytoplasmic organels and others with finely granular dense cores.

• MeSH
• finanční podpora výzkumu jako téma MeSH
• gastrointestinální nádory klasifikace   patologie   ultrastruktura   MeSH
• imunohistochemie MeSH
• intranukleární inkluzní tělíska enzymologie   imunologie   ultrastruktura   MeSH
• leiomyom diagnóza   etiologie   genetika   MeSH
• lidé MeSH
• organely MeSH
• proteiny eozinofilních granul imunologie   klasifikace   ultrastruktura   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH
• srovnávací studie MeSH

• Klíčová slova
• personalistika,
• MeSH
• organizace a řízení MeSH
• personální rozvoj MeSH
• výběr pracovníků MeSH
• Publikační typ
• příručky MeSH

• Konspekt
• Management. Řízení
• NLK Obory
• psychologie, klinická psychologie
• ekonomie, ekonomika, ekonomika zdravotnictví