Khurana, R* Dotaz Zobrazit nápovědu
Ninth edition 2 svazky : ilustrace, tabulky ; 28 cm
The 9th Edition covers all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders. For clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation.
- Konspekt
- Patologie. Klinická medicína
- Učební osnovy. Vyučovací předměty. Učebnice
- NLK Obory
- alergologie a imunologie
- NLK Publikační typ
- kolektivní monografie
- Klíčová slova
- axikabtagen ciloleucel,
- MeSH
- antitumorózní látky terapeutické užití MeSH
- difúzní velkobuněčný B-lymfom farmakoterapie komplikace MeSH
- lidé MeSH
- neurotoxické syndromy * diagnóza etiologie MeSH
- paměťové T-buňky MeSH
- retrospektivní studie MeSH
- věkové faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- dopisy MeSH
The regimen of carfilzomib, daratumumab, and dexamethasone (KdD) shows activity in patients with relapsed/refractory multiple myeloma. KdD at the twice-weekly 56 mg/m2 carfilzomib dose (KdD56) was used in the randomized phase 3 CANDOR study (NCT03158688), whereas KdD at the once-weekly 70 mg/m2 carfilzomib dose (KdD70) was used in the phase 1 b EQUULEUS study (NCT01998971). We analyzed efficacy data from comparable CANDOR and EQUULEUS patients using inverse probability of treatment weighting (IPTW)-adjusted models. These weights were calculated from propensity scores derived to balance prespecified baseline covariates. The side-by-side and adjusted comparisons showed similar efficacy for overall response rates and progression-free survival in the two groups, with a series of sensitivity analyses showing consistent findings. Safety data were generally consistent with the known safety profiles of each individual drug. Once-weekly KdD70 is comparable to twice-weekly KdD56 in terms of efficacy and safety while being a more convenient dosing option.
- MeSH
- dexamethason terapeutické užití MeSH
- lidé MeSH
- mnohočetný myelom * farmakoterapie MeSH
- monoklonální protilátky MeSH
- oligopeptidy škodlivé účinky MeSH
- protokoly antitumorózní kombinované chemoterapie * škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Diploid A genome wheat species harbor immense genetic variability which has been targeted and proven useful in wheat improvement. Development and deployment of sequence-based markers has opened avenues for comparative analysis, gene transfer and marker assisted selection (MAS) using high throughput cost effective genotyping techniques. Chromosome 2A of wheat is known to harbor several economically important genes. The present study aimed at identification of genic sequences corresponding to full length cDNAs and mining of SSRs and ISBPs from 2A draft sequence assembly of hexaploid wheat cv. Chinese Spring for marker development. In total, 1029 primer pairs including 478 gene derived, 501 SSRs and 50 ISBPs were amplified in diploid A genome species Triticum monococcum and T. boeoticum identifying 221 polymorphic loci. Out of these, 119 markers were mapped onto a pre-existing chromosome 2A genetic map consisting of 42 mapped markers. The enriched genetic map constituted 161 mapped markers with final map length of 549.6 cM. Further, 2A genetic map of T. monococcum was anchored to the physical map of 2A of cv. Chinese Spring which revealed several rearrangements between the two species. The present study generated a highly saturated genetic map of 2A and physical anchoring of genetically mapped markers revealed a complex genetic architecture of chromosome 2A that needs to be investigated further.
- MeSH
- chromozomy rostlin genetika MeSH
- diploidie MeSH
- jednonukleotidový polymorfismus MeSH
- lokus kvantitativního znaku * MeSH
- mapování chromozomů metody MeSH
- mikrosatelitní repetice MeSH
- polyploidie MeSH
- pšenice genetika MeSH
- sekvenční analýza DNA MeSH
- vysoce účinné nukleotidové sekvenování MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
