• Klíčová slova
• psychoedukace,
• MeSH
• duševně nemocní * psychologie   MeSH
• lidé MeSH
• psychoterapie metody   MeSH
• randomizované kontrolované studie jako téma MeSH
• rodinná terapie * metody   MeSH
• vztahy mezi lékařem a pacientem MeSH
• vztahy mezi odborníkem a rodinou MeSH
• zotavení z duševní nemoci MeSH
• Check Tag
• lidé MeSH

Kvalita života u schizofrenie je hodnotící kritérium, které vypovídá o adaptaci na nemoc a umožňuje ověřovat účinnost a úspěšnost různých druhů terapeutických intervencí. Přestože se původně předpokládalo, že kvalita života se zhoršuje až během onemocnění, studie potvrzují snížení kvality života již u první epizody schizofrenie, což negativně ovlivňuje funkční adaptaci pacientů a snižuje pravděpodobnost úzdravy. Mezi nejčastěji detekované koreláty snížené kvality života patří negativní a depresivní symptomy, zhoršená sociální kognice, nosognosie, sebestigmatizace a délka neléčené psychózy. Pacientům s první epizodou schizofrenie by měl být co nejdříve po stanovení diagnózy nabízen adekvátní komplexní terapeutický program, jehož součástí jsou intervence zvyšující kvalitu života, například rodinná psychoedukace, nácvik sociálních dovedností a léčba depresivní symptomatiky.

Quality of life in patients with schizophrenia is an assessment criterion, which reflects an adaptation to this illness and enables to verify the effectiveness and success of various types of therapeutic interventions. Although initially expected that quality of life is deteriorating up during illness, most studies have confirmed a worse outcome in quality of life already since the first-episode schizophrenia, which negatively affects the functional adaptation of patients and reduces the likelihood of recovery. Among the most frequently detected correlates of reduced quality of life are negative and depressive symptoms, impaired social cognition, good insight, self-stigma and duration of untreated psychosis. Patients diagnosed with first episode schizophrenia should be offered adequate and comprehensive programme as soon as possible, including interventions increasing quality of life, such as family psychoeducation, social skills training and proper treatment of depressive symptoms.

• MeSH
• adaptace psychologická MeSH
• časové faktory MeSH
• kvalita života * MeSH
• lidé MeSH
• schizofrenie (psychologie) * MeSH
• schizofrenie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• práce podpořená grantem MeSH
• přehledy MeSH

• Publikační typ
• abstrakt z konference MeSH

OBJECTIVES: Deficit in visuospatial functions can influence both simple and complex daily life activities. Despite the fact that visuospatial deficit was reported in schizophrenia, research on visuospatial functions as an independent entity is limited. Our study aims to elucidate the impact of visuospatial deficit in comparison with verbal deficit on global functioning and quality of life in the first psychotic episode of schizophrenia spectrum disorder (FES). The significance of clinical symptoms and antipsychotic medication was also studied. METHODS: Thirty-six FES patients and a matched group of healthy controls (HC group) were assessed with a neuropsychological battery focused on visuospatial (VIS) and verbal (VERB) functions. Using multiple regression analysis, we evaluated the cumulative effect of VERB and VIS functions, psychiatric symptoms (PANSS) and antipsychotic medication on global functioning (GAF) and quality of life (WHOQOL-BREF) in the FES group. RESULTS: The FES group demonstrated significant impairment both in VIS and VERB cognitive abilities compared to the HC group. Antipsychotic medication did not significantly affect either VIS or VERB functioning. PANSS was not related to cognitive functioning, apart from the Trail Making Test B. In the FES group, the GAF score was significantly affected by the severity of positive symptoms and VERB functioning, explaining together 60% of GAF variability. The severity of negative and positive symptoms affected only the Physical health domain of WHOQOL-BREF. The degree of VERB deficit was associated with both Physical and Psychological health. Although we did not find any relation between VIS functioning, GAF, and WHOQOL-BREF, a paradoxical finding emerged in the Environment quality domain, where a worse quality of the environment was associated with better VIS functioning. CONCLUSIONS: Our results suggest that the deficit in VIS functions is an integral part of cognitive deficit in schizophrenia spectrum disorders, rather than a side effect of symptomatology or antipsychotic medication. Moreover, VERB functioning was a better predictor of GAF and WHOQOL-BREF than VIS functioning. Given the findings of negative or missing effect of VIS deficit on WHOQOL-BREF and GAF, the accuracy of these measures in evaluating the impact of global cognitive deficit on everyday life in schizophrenia could be questioned.

• Publikační typ
• časopisecké články MeSH

• Publikační typ
• abstrakt z konference MeSH

• Publikační typ
• abstrakt z konference MeSH