Q106984294
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The association of mesothelioma, a lethal lung disease, with asbestos has led to an absolute ban on asbestos in at least 55 countries worldwide. The purpose of this paper is to review residual exposure to asbestos as well as other emerging causes of mesothelioma outside asbestos. The review provides detailed description of asbestos minerals, their geographical locations, mesothelioma in these areas, as well as contemporary possible sources of asbestos exposure. Second, we examine other emerging causes of mesothelioma including: ionizing radiation as the second most important risk factor after asbestos, particularly relevant to patients undergoing radiotherapy, third, carbon nanotubes which are under investigation and fourth, Simian virus 40. In the case of asbestos per se, the greatest risk is from occupational exposure during mining and subsequent processing. Of the non-occupational exposures, environmental exposure is most serious, followed by exposure from indoor asbestos minerals and secondary familial exposure. Overall, asbestos is still a major risk factor, but alternative causes should not be neglected, especially in young people, in women and those with a history of radiotherapy or living in high-risk locations.
- MeSH
- azbest * škodlivé účinky MeSH
- lidé MeSH
- maligní mezoteliom * chemicky indukované komplikace MeSH
- mezoteliom * chemicky indukované komplikace MeSH
- minerály MeSH
- mladiství MeSH
- nádory pleury * chemicky indukované komplikace MeSH
- nádory plic * chemicky indukované MeSH
- nanotrubičky uhlíkové * MeSH
- vystavení vlivu životního prostředí škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
OBJECTIVES: The study focused on the relationship between routine clinical characteristics and anti-SARS-CoV-2 specific antibodies in a pilot sample of healthcare workers (HCWs) having suffered COVID-19. The aim was to investigate the existence of readily available predictors of antibodies against COVID-19. METHODS: As part of the recognition of COVID-19 as an occupational disease in 152 HCWs with the mean age of 43.2 years, personal, anthropometric and anamnestic data related to the disease as well as anti-spike immunoglobulin (Ig) levels were obtained. Through descriptive statistics, correlation and regression analyses, relationships of all variables and Ig levels, especially seropositivity of IgG, were investigated. RESULTS: The mean interval between the symptom onset and the determination of antibodies was 58 days. IgG seropositivity and IgM seropositivity were noted in 82 % and 49 % of HCWs, respectively. Symptom duration was the only statistically significant predictor of IgG seropositivity. With each day of symptom duration, the probability of IgG seropositivity increased from 1.078 to 1.092 times (p < 0.05). If symptoms lasted longer than 17 days, a majority (almost 80 %) of the subjects demonstrated seropositivity in the following months. CONCLUSION: The presence of IgG immunity may be assumed from symptom duration. Such easy recognizing of seropositive patients may be a useful tool, e.g. in vaccination strategies (Tab. 3, Fig. 1, Ref. 28).
- Klíčová slova
- séropozitivita, trvání nemoci,
- MeSH
- COVID-19 * imunologie MeSH
- dospělí MeSH
- imunoglobulin G * imunologie krev MeSH
- Kaplanův-Meierův odhad MeSH
- lidé středního věku MeSH
- lidé MeSH
- logistické modely MeSH
- nemoci z povolání imunologie MeSH
- průřezové studie MeSH
- regresní analýza MeSH
- statistika jako téma MeSH
- zdravotnický personál statistika a číselné údaje MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Geografické názvy
- Česká republika MeSH
OBJECTIVES: Asbestos-related diseases are still a current problem worldwide. What is their occurrence in the Czech Republic? The answer is the subject of this study, which aims to provide a general and regional overview of the situation over the last 20 years with a more detailed focus on mesothelioma, the development of which is highly associated with asbestos exposure and the issue of their recognition as an occupational disease. METHODS: In its retrospective reviews, the study is based on analyses of data from the Institute of Health Information and Statistics of the Czech Republic and data from the Czech National Cancer Registry, which also interconnects. RESULTS: In the last 20 years, 512 new cases of occupational diseases from asbestos have been reported, namely 228 cases of pleural thickening, 133 mesotheliomas, 92 asbestoses, and 59 cases of lung cancer. In the last 5 years, mesotheliomas (n = 39) predominated among the reported diseases with a 45% proportion in the total number of 86 cases. The trend in their incidence, as the only one among asbestos-related diseases, is not declining. There was a significant difference in the overall incidence of mesothelioma in a general population and the incidence of occupational mesotheliomas. At the national level, occupational aetiology was acknowledged in only 11.3% of cases of mesothelioma on average. The highest proportion of occupational mesotheliomas and the highest incidence of all asbestos-related diseases were found in regions where the largest asbestos processing plants were located. CONCLUSION: The authors emphasize the importance of work history for the diagnostic process of asbestos-related diseases and also the need to perform follow-up examinations for their early detection.
- MeSH
- azbest * toxicita MeSH
- lidé MeSH
- mezoteliom * chemicky indukované epidemiologie MeSH
- nemoci z povolání * epidemiologie MeSH
- retrospektivní studie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- přehledy MeSH
- Geografické názvy
- Česká republika MeSH
Úvod: Zdraví zdravotníků je vystaveno řadě rizikových faktorů, ke kterým se řadí i noční práce. Cílem předkládané studie bylo zhodnotit, zda se liší výskyt endpointu kardiovaskulárních onemocnění (EP) u zdravotníků vykonávajících a nevykonávajících noční práci, a to i s ohledem na dříve stanovené riziko vzniku kardiovaskulárního onemocnění (KVO). Metodika: V roce 2002–2007 byla u 3 210 zaměstnanců velké nemocnice stanovena míra rizika vzniku KVO podle Framinghamské studie. Pro další hodnocení byla vybrána skupina zdravotníků, kteří měli stanovené riziko KVO nad 10 % (n = 240). U těchto osob byly zjišťovány informace o výskytu EP po 10–15 letech, data byla přístupná u 175 osob. K tomuto souboru byl k odstranění vlivu věku a pohlaví vybrán metodou přizpůsobení (matching) kontrolní soubor 175 osob s rizikem vzniku KVO pod 10 %. Byl srovnáván výskyt EP u pracujících v noci a u nepracujících v noci i s ohledem na celkové riziko KVO. Výsledky: V souboru 175 pracovníků s rizikem KVO nad 10 % bylo 73 osob pracujících v noci, EP byl zaznamenán u 19,2 % z nich. Ve skupině 102 zdravotníků, nepracujících v noci byl zaznamenán EP u 16,7 %, rozdíl nebyl signifikantní. V kontrolním souboru vykonávalo noční práci 82 osob, EP byl zjištěn u 11,0 % z nich, 93 osob tohoto souboru noční práci nevykonávalo, EP byl shledán u 10,8 %, rozdíl nebyl statisticky významný. Větší rozdíl ve výskytu EP byl při srovnání skupiny pracovníků s rizikem KVO nad 10 % a navíc konajících noční služby (19,2 %) se skupinou osob s rizikem KVO pod 10 % a bez nočních služeb (10,7 %), ale ani tento rozdíl nebyl signifikantní (p = 0,1255). Závěr: Výskyt EP byl vyšší ve skupině pracujících v noci zejména ve spojení s dalšími rizikovými faktory KVO, rozdíly však nebyly statisticky významné. Omezením studie jsou zejména malé počty osob v jednotlivých skupinách. Problematika vyžaduje další zkoumání.
Introduction: Healthcare professionals are exposed to a number of risk factors, including night work. The present study aimed to assess whether the incidence of cardiovascular disease endpoints (EP) differs in night work performing and non-performing healthcare professionals, with respect to the previously established risk of developing cardiovascular disease (CVD). Methods: To a sample of 3,210 workers of a large hospital, a risk of CVD was assigned according to the Framingham heart study between 2002 and 2007. For further evaluation, a group of healthcare professionals who had a given CVD risk above 10% (n = 240) was selected. In these individuals, data on the occurrence of EP in previous 10-15 years were found, the data were accessible to 175 people. A control group of 175 workers with a CVD risk below 10% was added to remove the influence of age and gender. The incidence of EP was compared in those performing and non-performing night work with regard to the overall risk of CVD. Results: In the group of 175 workers with CVD risk above 10%, there were 73 persons working at night, EP was recorded in 19.2% of them. In 102 night work non-performing healthcare professionals, the EP was recorded in 16.7% of them, the difference was not significant. In the control group, 82 healthcare professionals worked at night, 11.0% of them had EP, whereas 93 professionals of the group did not work at night, the EP was found at 10.8% of them, the difference was not statistically significant. A greater difference in the occurrence of EP was found when compared the EP incidence in a sample of night work performing professionals with CVD risk over 10% (19.2%) with a sample of night work non-performing professionals with CVD risk below 10% (10.7%), however, the difference was not significant (p = 0.1255) either. Conclusion: The incidence of EP was higher in night working healthcare professionals, especially in a connection with other risk factors of CVD, but the differences were not statistically significant. The limitation of the study is a small number of individuals in both groups. This issue requires further investigation.
