Q98237020
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125 stran ; 29 cm
- MeSH
- farmaceutická chemie MeSH
- farmaceutická technologie MeSH
- lékové formy MeSH
- příprava léků MeSH
- Publikační typ
- učebnice MeSH
The healthy development of the fetus depends on the exact course of pregnancy and delivery. Therefore, prenatal hypoxia remains between the greatest threats to the developing fetus. Our study aimed to assess the impact of prenatal hypoxia on postnatal development and behavior of the rats, whose mothers were exposed to hypoxia (10.5 % O2) during a critical period of brain development on GD20 for 12 h. This prenatal insult resulted in a delay of sensorimotor development of hypoxic pups compared to the control group. Hypoxic pups also had lowered postnatal weight which in males persisted up to adulthood. In adulthood, hypoxic males showed anxiety-like behavior in the OF, higher sucrose preference, and lower levels of grimace scale (reflecting the degree of negative emotions) in the immobilization chamber compared to the control group. Moreover, hypoxic animals showed hyperactivity in EPM and LD tests, and hypoxic females had reduced sociability compared to the control group. In conclusion, our results indicate a possible relationship between prenatal hypoxia and changes in sociability, activity, and impaired emotion regulation in ADHD, ASD, or anxiety disorders. The fact that changes in observed parameters are manifested mostly in males confirms that male sex is more sensitive to prenatal insults.
- MeSH
- acidobazická rovnováha MeSH
- bludiště - učení MeSH
- chování zvířat * MeSH
- gestační stáří MeSH
- hypoxie plodu komplikace patofyziologie MeSH
- modely nemocí na zvířatech MeSH
- pohybová aktivita MeSH
- potkani Wistar MeSH
- preference v jídle MeSH
- senzorimotorický kortex růst a vývoj MeSH
- sexuální faktory MeSH
- sociální interakce MeSH
- těhotenství MeSH
- úleková reakce MeSH
- věkové faktory MeSH
- zpožděný efekt prenatální expozice * MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
