Microorganisms do not live alone, but rather they communicate using diverse „languages“. In general, each bacterial species produces and responds to a unique autoinducer signal. Gram-negative bacteria use N-acylated homoserine lactones and gram-positive bacteria use oligopeptides as autoinducers. Function of autoinducer 2 is bacterial interspecies cell-to-cell communication. The structure and function of two main signaling molecules (farnesol and tyrosol) in the C. albicans quorum sensing (QS) system were also already described. Signaling molecules control the behavior of the whole population (especially virulence factors expression). That’s why QS systems represent a new therapeutic target, especially because of an increasing worldwide antibiotic resistance. Quorum sensing inhibitors are a promising direction in the treatment of infection caused by pathogenic micro¬organisms.
- Klíčová slova
- signální molekuly, N-acyl-homoserin lakton, inhibitory quorum sensing,
- MeSH
- antibakteriální látky MeSH
- antiinfekční látky MeSH
- Bacteria genetika klasifikace metabolismus patogenita MeSH
- bakteriální léková rezistence MeSH
- biofilmy MeSH
- Candida albicans patogenita MeSH
- česnek MeSH
- houby metabolismus patogenita MeSH
- kvasinky metabolismus patogenita MeSH
- léčivé rostliny chemie klasifikace MeSH
- mezibuněčná komunikace MeSH
- Pseudomonas aeruginosa patogenita MeSH
- quorum sensing * fyziologie genetika účinky léků MeSH
- signální transdukce MeSH
- Vibrio cholerae patogenita MeSH
- virulence genetika MeSH
- Publikační typ
- přehledy MeSH
