- Klíčová slova
- MASLD,
- MeSH
- jaterní testy metody MeSH
- játra metabolismus patologie MeSH
- kazuistiky jako téma MeSH
- kyselina ursodeoxycholová farmakologie terapeutické užití MeSH
- lidé středního věku MeSH
- lidé MeSH
- nealkoholová steatóza jater * farmakoterapie klasifikace patofyziologie MeSH
- ztučnělá játra diagnóza etiologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- přehledy MeSH
Background and Objectives: Initial diagnosis of brest cancer (BC) is important for fate and prognosis of the diseases profile, we sought to identify the correlation between Midkine (MK) as a new biomarker with cancer antigen (CA)15-3, liver function test, renal function test, blood cells parameters in individuals with invasive ductal carcinoma.Methods: The serum MK and CA15-3 of all subjects were measured by the ELISA technique, Liver enzymes were measured by colourimetric methods and neutrophils, and lymphocytes were measured by an Electrical Impedance Cell Counting method (automated machine).Results: The results of the correlation among serum MK and other parameters in invasive ductal carcinoma of the breast showed a considerable positive correlation among MK and CA15-3 and measured white blood cells. Moreover, there were a weak correlation with Aspartate Aminotransferase (AST) and RBC, while there is no correlation between serum MK and other liver enzymes or blood parameters. Conclusion: The study results of the correlation between serum MK and other parameters in colorectal carcinoma patients show a significant positive correlation of MK with CA15-3 markers in invasive ductal carcinoma of the breast.
- MeSH
- duktální karcinom prsu krev MeSH
- ELISA metody MeSH
- jaterní testy MeSH
- klinická studie jako téma metody MeSH
- lidé MeSH
- lymfocyty metabolismus MeSH
- midkin * analýza krev MeSH
- nádorové biomarkery * krev MeSH
- nádory prsu * diagnóza krev MeSH
- neutrofily metabolismus MeSH
- vyšetření funkce ledvin MeSH
- Check Tag
- lidé MeSH
Background: The second-leading source of neoplasm-related death and a primary factor in gastrointestinal cancer, colorectal cancer (CCR) affects both genders globally. Poor eating behaviours, tobacco, an intestinal inflammatory disorder, swellings, inherited characteristics, and the elderly all increase the threat of acquiring this malignancy. The illness is more hostile in patients detected at earlier ages, although 90% of patients with colorectal tumours are older than 50, with a median oldness of 64 years. American Cancer Association estimates that it caused more than 49,700 fatalities in 2015.Objectives: Study the correlation of midkine with carcinoembryonic antigen (CEA), liver function tests, and white blood cell count in patients with colorectal carcinoma.Methods: The serum midkine and CEA of all subjects were measured by the ELISA technique, Liver enzymes were measured by colourimetric methods and neutrophils, and lymphocytes were measured by an Electrical Impedance Cell Counting method (automated machine).Conclusion: The study results of the correlation between serum midkine and other parameters in colorectal carcinoma patients show a significant positive correlation of midkine with CEA, liver enzyme, neutrophils, and lymphocytes.
- MeSH
- dospělí MeSH
- hematologické testy metody MeSH
- jaterní testy metody MeSH
- karcinoembryonální antigen krev MeSH
- kolorektální nádory * krev MeSH
- leukocyty MeSH
- lidé středního věku MeSH
- lidé MeSH
- midkin * krev MeSH
- nádorové biomarkery krev MeSH
- prognóza MeSH
- statistika jako téma MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- klinická studie MeSH
Background and Purpose: T2DM is the most common cause of end- stage liver diseases, and different mechanisms contribute to diabetic hepatopathy's wide spectrum presentation. In this study, we aimed to identify abnormalities in liver function tests (LFTs) for a group of Iraqi T2DM patients, determine their prevalence, and investigate the influence of some independent co-variables (duration of DM, HbA1c, BMI, age, and gender). Methods: This case-control study enrolled 43 T2DM patients alongside 40 healthy, age- and sex- matched non-diabetic subjects. After overnight fasting, blood was collected, and fasting plasma glucose (FPG), HbA1c, and serum LFTs (AST, ALT, ALP, total proteins, albumin, and bilirubin) were measured in addition to serum lipids.Results: T2DM patients exhibited significantly higher FPG, HbA1c, AST, and ALT mean values than the controls. Serum aminotransferases were increased in 30% of patients. Serum albumin and total bilirubin (TSB) decreased in 18.6 and 37.2% respectively. Diabetics with HbA1c>7.0% had significantly higher AST, ALT, ALP, and STP values and lower serum albumin and TSB. The logistic regression analysis revealed that duration, BMI, HbA1c, and age are independent co-variables significantly linked to increased ALT activity. Conclusions: LFTs (mainly aminotransferases) are altered in DM. The duration of diabetes, the age of the patient, BMI, and glycemic control influence this change. We recommend monitoring LFTs in DM and maintaining good glycemic control.
- MeSH
- biochemická analýza krve * statistika a číselné údaje MeSH
- diabetes mellitus 2. typu * krev MeSH
- dospělí MeSH
- glykovaný hemoglobin analýza MeSH
- jaterní testy statistika a číselné údaje MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- transaminasy krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- klinická studie MeSH
To explore the efficacy and safety of a small-volume-plasma artificial liver support system (ALSS) in the treatment of acute-on-chronic liver failure (ACLF). A retrospective analysis was performed. All ACLF patients received ALSS of plasma exchange & double plasma molecular absorb system (PE+DPMAS) treatment, and successfully completed this treatment. Patients were divided into small-volume and half-volume plasma groups. We compared the changes of the indicators on liver function, kidney function, blood coagulation function, and blood ammonia level before and after PE+DPMAS treatment; we compared the short-term and long-term curative effects between small-volume and half-volume plasma groups; and the factors influencing Week 4 and Week 12 mortality of ACLF patients were analyzed. The Week 4 improvement rates were 63.96 % and 66.86 % in the small-volume and half-volume plasma groups, respectively. The Week 12 survival rates in the small-volume-plasma and half-volume plasma groups were 66.72 % and 64.61 %, respectively. We found several risk factors affecting Week 4 and Week 12 mortality. Kaplan-Meier survival curves suggested no significant difference in Week 4 and Week 12 survival rates between the small-volume and half-volume plasma groups (P=0.34). The small-volume-plasma PE+DPMAS treatment could effectively reduce bilirubin and bile acids, and this was an approach with high safety and few complications, similar to the half-volume-plasma PE+DPMAS treatment. The small-volume-plasma PE+DPMAS has the advantage of greatly reducing the need for intraoperative plasma, which is especially of importance in times of shortage of plasma.
- MeSH
- biologické markery analýza MeSH
- enzymy analýza MeSH
- gama-glutamyltransferasa analýza MeSH
- jaterní testy MeSH
- kyselina ursodeoxycholová aplikace a dávkování farmakologie MeSH
- lidé MeSH
- metabolický syndrom * diagnóza komplikace terapie MeSH
- nemoci jater * diagnóza etiologie terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- novinové články MeSH
The precise method of action of dienogest on the production and development of endometriosis lesions is unknown, and its controversial effect on endometrial thickness has been under investigation. In the following study the Dienogest's effects on the target animal's histology of female reproductive organs, including the tissues from the Fallopian tubes, ovaries, and uterus, as well as the impact of drug administration on the liver's enzymes and the drug's effects on triglycerides, body weight, and HbA1c, have all been studied. The findings of the following experiment indicated that there was no significant elevation of liver enzymes. The little to no elevation of the liver enzymes indicated that the drug did not induce stress on the hepatic cells and according to the subsequent experiment it is safe for clinical use. Moreover, after 10, 20, and 30 days of blood administration, the level of blood TG significantly decreased, and after 30 days of intake, the level of blood sugar significantly decreased. However, there were no appreciable changes after 10 and 20 days. After 30 days of treatment, the rats' weight also showed a very minor drop. In addition to it, the results of histological changes in the tissue in the following study represented that there were evident changes in the tissues which comprised of decline in blood circulation, fibrosis in tissues, and degeneration of follicles.
- Klíčová slova
- dienogest,
- MeSH
- histologické techniky MeSH
- jaterní testy metody přístrojové vybavení MeSH
- játra enzymologie účinky léků MeSH
- kontraceptiva * farmakologie krev metabolismus MeSH
- modely u zvířat MeSH
- potkani Sprague-Dawley MeSH
- progesteron farmakologie krev metabolismus MeSH
- statistika jako téma MeSH
- transaminasy analýza krev účinky léků MeSH
- ženské pohlavní orgány * patologie účinky léků MeSH
- Check Tag
- ženské pohlaví MeSH
- Publikační typ
- klinická studie MeSH
Úvod: Rozsáhlé resekční výkony na játrech jsou spojeny s rizikem vývoje jaterního selhání. V rámci indikace k operačnímu výkonu je využívána řada přímých i nepřímých metod k hodnocení funkce jaterního parenchymu i předpokládaného poresekčního rezidua. Řešená problematika: Morfologické metody odhadují funkci zejména na základě informace o objemu budoucího rezidua, laboratorní testy posuzují spíše globální funkci a nemusejí vždy korelovat s prognózou pacientů. Ze scintigrafické diagnostiky mají potenciál postupy založené na sledování akumulace derivátů iminodioctové kyseliny (IDA), zejména se jedná o stanovení hepatální extrakční frakce a výpočet rychlosti nárůstu aktivity v jaterním parenchymu. Druhý uvedený postup umožňuje identifikovat pacienty v potenciálním riziku jaterního selhání po resekčním výkonu i díky literárně definovaným hraničním hodnotám. Závěr: Scintigrafické metody mohou být využity v odhadu funkčního stavu budoucího rezidua jater, a tím i sloužit v algoritmu indikace pacientů k rozsáhlým resekčním výkonům. Z možných vyšetření umožňuje identifikovat pacienty v riziku jaterního selhání po operačním výkonu zejména výpočet rychlosti akumulace derivátu IDA v jaterním parenchymu.
Introduction: Extensive resections in liver parenchyma can lead to the liver dysfunction or liver failure due to the insufficient postoperative remnant. Indication process involves direct and indirect methods for the assessment of liver function. Topic solved: Morphological imaging methods estimate the liver remnant function mainly based on the volume calculations. Laboratory tests asses rather global function and they may not always correlate with the patient’s prognosis. Scintigraphic methods include monitoring of accumulation of iminodiacetic acid derivatives (IDA), especially determination of hepatic extraction fraction (HEF) and calculation of IDA uptake rate in liver parenchyma. Conclusion: Scintigraphic methods can be used for the estimation of the liver remnant function during the indication for the extensive liver resections. Especially the calculation of IDA uptake rate in liver parenchyma is potent to identify patients in a higher risk of future liver failure.
- MeSH
- alkoholová abstinence MeSH
- diabetes mellitus 1. typu * farmakoterapie MeSH
- inzuliny aplikace a dávkování MeSH
- jaterní testy MeSH
- krevní glukóza * analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- neúspěšná terapie MeSH
- odmítnutí terapie pacientem MeSH
- pití alkoholu škodlivé účinky MeSH
- progrese nemoci MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
