Aggressive behavior is one of the most disturbing symptoms of Alzheimer disease and other progressive neurodegenerative dementias. Development of strategies for management of aggressive behaviors in people with dementia is hindered by a lack of recognition that aggression is not a uniform behavioral construct. It is possible to distinguish 2 types of aggression: reactive or impulsive aggression and proactive or premeditated aggression. Research concerning aggressive behaviors in people with dementia is hindered by scales describing behavioral symptoms of dementia which do not distinguish between reactive and proactive aggressions because they do not consider the factors leading to these behaviors. Reactive aggression is caused by lack of understanding, leading to rejection of care, while proactive aggression could be caused by a psychopathic personality, hallucinations or delusions, and other determinants. It is difficult to underestimate the importance of distinguishing reactive and proactive aggressions in people with dementia because there are different strategies that can be used for management of these behaviors. For reactive aggression, delayed treatment, distraction, improved communication, and change in treatment strategy is useful, while antipsychotic medication may be needed for treatment of proactive aggression. Dementia is increasing the risk of both types of aggressions and antidepressant treatment can be helpful. Most importantly, persons exhibiting reactive aggression should not be labeled "aggressors" because this behavior could be caused by unmet persons' needs, pain and poor communication with care providers.

• Keywords
• Alzheimer disease, aggression, agitation, behavioral therapy, dementia,
• MeSH
• Aggression MeSH
• Antidepressive Agents MeSH
• Antipsychotic Agents * MeSH
• Antisocial Personality Disorder MeSH
• Dementia * diagnosis   therapy   MeSH
• Humans MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Antidepressive Agents MeSH
• Antipsychotic Agents * MeSH

Traces of psychoactive substances have been found in freshwaters globally. Fish are chronically exposed to pollution at low concentrations. The changes of aggressive behaviour of chub (Squalius cephalus) were determined under the exposure to four psychoactive compounds (sertraline, citalopram, tramadol, methamphetamine) at environmentally relevant concentrations of 1 μg/L for 42 days. We tested whether (A) the behavioural effect of compounds varies within a single species; (B) there is a correlation between the individual brain concentration of the tested pollutants and fish aggression using the novel analysis of pollutants in brain; and (C) there is detectable threshold to effective pollutant concentration in brain. Behaviour and pollutant concentrations in brain were determined repeatedly (1st, 7th, 21st, 42nd and 56th days), including a two-week-long depuration period. The effect of particular compounds varied. Citalopram and methamphetamine generally increased the fish aggression, while no such effect was found after exposure to tramadol or sertraline. The longitudinal analysis showed an aggression increase after depuration, indicating the presence of withdrawal effects in methamphetamine- and tramadol-exposed fish. The analysis of pollutant concentration in brain revealed a positive linear relationship of citalopram concentration and aggression, while no such effect was detected for other compounds and/or their metabolites. Structural break analyses detected concentration thresholds of citalopram (1 and 3 ng/g) and sertraline (1000 ng/g) in brain tissue, from which a significant effect on behaviour was manifested. While the effect of sertraline was not detected using traditional approaches, there was a reduction in aggression after considering its threshold concentration in the brain. Our results suggest that pursuing the concentration threshold of psychoactive compounds can help to reduce false negative results and provide more realistic predictions on behavioural outcomes in freshwater environments, especially in the case of compounds with bioaccumulation potential such as sertraline.

• Keywords
• Citalopram, Methamphetamine, Pharmaceuticals, Sertraline, Tramadol, Withdrawal effects,
• MeSH
• Aggression MeSH
• Water Pollutants, Chemical * toxicity   MeSH
• Cyprinidae * MeSH
• Pharmaceutical Preparations * MeSH
• Fresh Water MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Water Pollutants, Chemical * MeSH
• Pharmaceutical Preparations * MeSH

This review examined aggressive behavior in Borderline Personality Disorder (BPD) and its management in adults. Aggression against self or against others is a core component of BPD. Impulsiveness is a clinical hallmark (as well as a DSM-IV-TR diagnostic criterion) of BPD, and aggressive acts by BPD patients are largely of the impulsive type. BPD has high comorbidity rates with substance use disorders, Bipolar Disorder, and Antisocial Personality Disorder; these conditions further elevate the risk for violence. Treatment of BDP includes psychodynamic, cognitive behavioral, schema therapy, dialectic behavioral, group and pharmacological interventions. Recent studies indicate that many medications, particularly atypical antipsychotics and anticonvulsants, may reduce impulsivity, affective lability as well as irritability and aggressive behavior. But there is still a lack of large, double blind, placebo controlled studies in this area.

• MeSH
• Aggression psychology   MeSH
• Drug Therapy methods   MeSH
• Borderline Personality Disorder drug therapy   psychology   therapy   MeSH
• Humans MeSH
• Psychotherapy methods   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Review MeSH

AIMS: In clinical practice, overt aggressive behaviour is frequently observed in patients diagnosed with bipolar disorder. It can be dangerous and complicates patient care. Nevertheless, it has not been adequately studied as a phenomenon that is separate from other symptoms such as agitation. The aim of this review is to provide information on the prevalence, clinical context, and clinical management of aggression in patients with bipolar disorder. METHODS: MEDLINE and PsycInfo data bases were searched for articles published between 1966 and November 2008 using the combination of key words 'aggression' or 'violence' with 'bipolar disorder'. For the treatment searches, generic names of mood stabilisers and antipsychotics were used in combination with key words 'bipolar disorder' and 'aggression'. No language constraint was applied. Articles dealing with children and adolescents were not included. RESULTS: Acutely ill hospitalised bipolar patients have a higher risk for aggression than other inpatients. In a population survey, the prevalence of aggressive behaviour after age 15 years was 0.66% in persons without lifetime psychiatric disorder, but 25.34% in bipolar I disorder. Comorbidity with personality disorders and substance use disorders is frequent, and it elevates the risk of aggression in bipolar patients. Impulsive aggression appears to be the most frequent subtype observed in bipolar patients. Clinical management of aggression combines pharmacological and non-pharmacological approaches. DISCUSSION: A major problem with the evidence is that aggression is frequently reported only as one of the items contributing to the total score on a scale or a subscale. This makes it impossible to ascertain specifically aggressive behaviour. Large controlled head-to-head randomised controlled studies comparing treatments for aggressive behaviour in bipolar disorder are not yet available. There is some evidence favouring divalproex, but it is not particularly strong .We do not know if there are any efficacy differences among antipsychotics for this indication.

• MeSH
• Aggression psychology   MeSH
• Antipsychotic Agents therapeutic use   MeSH
• Bipolar Disorder epidemiology   psychology   therapy   MeSH
• Impulsive Behavior epidemiology   psychology   MeSH
• Humans MeSH
• Prevalence MeSH
• Cross-Sectional Studies MeSH
• Psychomotor Agitation psychology   therapy   MeSH
• Drug Administration Routes MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Antipsychotic Agents MeSH

Research is increasingly revealing that adolescents utilize electronic technologies to promote and/or maintain their social standing among their peer group. Little is known about whether adolescents' perceptions of popularity-motivated behaviors, characteristics, and relationships in cyberspace are associated with popularity-motivated cyber relational aggression. It is also unclear how gender might impact these associations, especially considering that adolescent girls and boys differ in regard to the type of behaviors, characteristics, and relationships they believe contribute to popularity. To this end, this study examined the potential moderating effect of gender on the association between adolescents' perceptions of popularity-motivated behaviors, characteristics, and relationships in cyberspace and their engagement in popularity-motivated cyber relational aggression over 1 year, from seventh to eighth grade. There were 217 eighth graders (51 percent female; M age = 12.13) from three middle schools in a large Midwestern city in the United States included in this research. They completed questionnaires on their popularity-motivated behaviors, characteristics, and relationships in cyberspace and their perpetration of popularity-motivated cyber relational aggression during the seventh grade. One year later, they completed the perpetration of popularity-motivated cyber relational aggression questionnaire. The results revealed that the association between popularity-motivated behaviors, characteristics, and relationships in cyberspace and the perpetration of popularity-motivated cyber relational aggression was stronger for girls, while such an association was not found for boys. These findings indicate the importance of considering cyberspace as an environment in which adolescents can enhance their social standing among peers from their school.

• Keywords
• adolescence, adolescent, cyber aggression, impression management, popularity, relational aggression,
• MeSH
• Aggression psychology   MeSH
• Gender Identity * MeSH
• Internet MeSH
• Humans MeSH
• Adolescent MeSH
• Motivation * MeSH
• Perception MeSH
• Surveys and Questionnaires MeSH
• Psychological Distance * MeSH
• Schools MeSH
• Peer Group * MeSH
• Check Tag
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

Adverse childhood experiences (ACEs), such as exposure to maltreatment and household dysfunction, are major risk factors for physical and mental health problems across the lifespan. While the relationship between ACEs and health outcomes is well established, what effects ACEs might have on parent-to-child aggression are less known. The negative consequences of ACEs on parental aggression can be even more pronounced with multiple exposures to different patterns of ACEs. This study examined the association between patterns of maternal ACEs and subsequent parent-child aggression risk. A diverse sample of young women (N = 329; mean age = 26.3 years) was recruited at a large, urban university medical center. Participants completed self-report measures of the ACEs Questionnaire and the Adult-Adolescent Parenting Inventory-2. Latent class analysis was used to identify classes of women with similar patterns of exposure to ACEs and to examine the associations between ACEs classes and parent-to-child aggression risk. Three latent classes, characterized by distinct patterns of maternal ACEs, were identified: Low ACEs (63% of the sample), High Parental Separation/Divorce (20%), and High/Multiple ACEs classes (17%). Women in the High/Multiple ACEs class were more likely to report higher levels of parent-to-child aggression risk (i.e., inappropriate expectations, belief in corporal punishment, lack of empathy) than those in the other classes (Wald(2) = 8.63, p = .013). Preventive interventions targeting parental attitudes and behaviors among young women exposed to ACEs may decrease the risk for further perpetuation of aggression in the next generations.

• Keywords
• Adult-Adolescent Parenting Inventory, adverse childhood experiences, parent-to-child aggression, parental aggression, parenting practices,
• MeSH
• Aggression MeSH
• Adult MeSH
• Humans MeSH
• Adolescent MeSH
• Adverse Childhood Experiences * MeSH
• Risk Factors MeSH
• Parents MeSH
• Parenting MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Adolescent MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

BACKGROUND: Impulsivity and aggression are known risk factors for suicide, with observed age and sex differences in their impact. AIMS: To explore variations in impulsivity and aggression based on sex and age and examine their roles in predicting suicide. METHOD: We examined 582 participants (406 individuals who died by suicide, 176 non-suicidal sudden-death controls) using the psychological autopsy method. Measures of impulsivity and aggression included the Barratt Impulsiveness Scale (BIS) and the Brown-Goodwin History of Aggression (BGHA). Participants were categorised into four groups: suicide male, control male, suicide female and control female. For group comparisons, we used analyses of variance and Spearman's rank correlation to assess the relationship between age and BIS and/or BGHA ratings. Stepwise logistic regression was used to identify predictors of suicide for each sex. RESULTS: Higher levels of BIS and BGHA ratings were found in the suicide group compared with controls (BIS: 51.3 v. 42.2, P = 0.002, η2 = 0.017; BGHA: 7.1 v. 4.1, P < 0.001, η2 = 0.028), with no significant sex differences. BIS and BGHA ratings decreased with age in the suicide groups (suicide male: impulsivity ρ = -0.327, P < 0.001; suicide female: aggression ρ = -0.175, P = 0.038) but not among controls. Logistic regression analysis revealed that for men, aggression (odds ratio 1.072, 95% CI: 1.032-1.112) was a key predictor. For women, younger age (odds ratio 0.970, 95% CI: 0.948-0.993), low BIS impulsivity ratings (odds ratio 1.018, 95% CI: 1.001-1.036) and living with children (odds ratio 0.448, 95% CI: 0.208-0.966) were protective factors. CONCLUSIONS: Impulsive and aggressive behaviours are critical factors in suicide risk among younger individuals, indicating an age effect but no sex dimorphism, with aggressive behaviours being a better predictor for men and impulsive and aggressive behaviours for women.

• Keywords
• Suicide, aggression, impulsivity, psychological autopsy, sex,
• Publication type
• Journal Article MeSH

Decades of research support the generalization that human males tend to be more aggressive than females. However, most of that research has examined aggression between unrelated individuals. Data drawn from 24 societies around the globe (n = 4,013) indicate that this generalization does not hold in the context of sibling relationships. In retrospective self-reports, females report being at least as aggressive as males toward their siblings, often more so. This holds for direct as well as indirect aggression, and for aggression between adult siblings as well as aggression that occurred during childhood. Consistent with prior research on sex differences, males reported engaging in more direct aggression toward nonkin than did females in the majority of societies. The results suggest that the dynamics of aggression within the family are different from those outside of it, and ultimately that understanding the role of sex in aggressive tendencies depends on context and target.

• Keywords
• aggression, sex differences, siblings, universal,
• Publication type
• Journal Article MeSH

In social mammals, the position of a male in the group's hierarchy strongly affects his reproductive success. Since a high social rank is often gained through competition with other males, selection should favour bigger males over smaller ones. We may therefore predict faster growth and/or delayed sexual maturity in dominant males. Likewise, dominants should have higher levels of testosterone, hormone important in many aspects of male dominance. Less obvious is the relationship between dominance and levels of corticosterone but generally higher concentrations are expected in subordinate individuals. We studied body growth, sexual maturation and endocrinal changes in males of two house mouse subspecies, raised in fraternal pairs. Since Mus musculus domesticus is the subspecies which dominates mutual encounters with Mus musculus musculus we predicted higher growth rate, delayed puberty and aggression, and higher testosterone and corticosterone levels in domesticus males compared to musculus. In all comparisons, no differences were found between dominant and subordinate musculus brothers. On the other hand, in M. m. domesticus, dominant males revealed a different growth trajectory and lower corticosterone levels than subordinate males but not delayed puberty and higher testosterone concentrations, thus contradicting our predictions. In inter-subspecific comparisons, musculus males matured earlier but became aggressive at the same time as domesticus males. The musculus testosterone ontogeny suggests that social positions in this subspecies remain unfixed for an extended period and that the increasing levels probably reflect prolonged hierarchy contests. It appears that the ontogeny of behaviour and physiological traits diverge cryptically between the two subspecies.

• Keywords
• Aggression, Corticosterone, Dominance, House mouse, Ontogeny, Testosterone,
• MeSH
• Aggression physiology   MeSH
• Body Mass Index * MeSH
• Corticosterone blood   MeSH
• Mice MeSH
• Reproduction physiology   MeSH
• Social Dominance * MeSH
• Testosterone blood   MeSH
• Animals MeSH
• Check Tag
• Male MeSH
• Mice MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Corticosterone MeSH
• Testosterone MeSH

It has been shown that nitric oxide (NO) increases aggression in male mice, whereas it decreases aggression in lactating female mice and prairie voles. It is also known that aggression can be exhibited at different levels in rodent species, strain or subtypes. The aims of this study were to investigate the proportion of aggressiveness in Wistar rats, the effect of intraperitoneally administered nonspecific nitric oxide synthase (NOS) inhibitor L-NAME (NG-nitro L-arginine methyl ester) on maternal aggression towards female intruders, and whether these effects are due to NO production or not. Rats were given saline intraperitoneally on the postpartum Day 2 and aggression levels were recorded. The same rats were given 60 mg/kg L-NAME or D-NAME (NG-nitro D-arginine methyl ester) on the postpartum Day 3 and their effects on aggression levels were compared to saline. While L-NAME administration did not cause any differences in the total number of aggressive behavior, aggression duration and aggression intensity, it reduced the proportion of animals showing aggressive behavior. In addition, the latency of the first aggression was significantly increased by L-NAME. In the D-NAME group, however, no significant change was found. Our results have shown that L-NAME reduces maternal aggression towards female intruders in Wistar rats through inhibition of NO production. These results suggest that the role of NO in offensive and defensive maternal aggression shares neural mechanisms.

• MeSH
• Aggression drug effects   MeSH
• Behavior, Animal drug effects   MeSH
• Enzyme Inhibitors pharmacology   MeSH
• Rats MeSH
• Maternal Behavior drug effects   MeSH
• NG-Nitroarginine Methyl Ester pharmacology   MeSH
• Nitric Oxide metabolism   MeSH
• Rats, Wistar MeSH
• Nitric Oxide Synthase antagonists & inhibitors   metabolism   MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Enzyme Inhibitors MeSH
• NG-Nitroarginine Methyl Ester MeSH
• Nitric Oxide MeSH
• Nitric Oxide Synthase MeSH