Milk is a complex physiological liquid that simultaneously provides nutrients and bioactive components that facilitate the successful postnatal adaptation of the newborn infant by stimulating cellular growth and digestive maturation, the establishment of symbiotic microflora, and the development of gut-associated lymphoid tissues. The number, the potency, and the importance of bioactive compounds in milk and especially in fermented milk products are probably greater than previously thought. They include certain vitamins, specific proteins, bioactive peptides, oligosaccharides, organic (including fatty) acids. Some of them are normal milk components, others emerge during digestive or fermentation processes. Fermented dairy products and probiotic bacteria decrease the absorption of cholesterol. Whey proteins, medium-chain fatty acids and in particular calcium and other minerals may contribute to the beneficial effect of dairy food on body fat and body mass. There has been growing evidence of the role that dairy proteins play in the regulation of satiety, food intake and obesity-related metabolic disorders. Milk proteins, peptides, probiotic lactic acid bacteria, calcium and other minerals can significantly reduce blood pressure. Milk fat contains a number of components having functional properties. Sphingolipids and their active metabolites may exert antimicrobial effects either directly or upon digestion.

• MeSH
• fermentace * MeSH
• lidé MeSH
• mateřské mléko * MeSH
• mléčné výrobky * MeSH
• mléko * MeSH
• novorozenec MeSH
• potraviny MeSH
• zdraví * MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• novorozenec MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Concentrated extracts of MRS (De Man-Rogosa-Sharpe) media in which probiotic bacterium Enterococcus faecium strain M-74 was grown exerted different antimutagenic activity against ofloxacin-, N-methyl, N'-nitro-N-nitrosoguanidine- and sodium 5-nitro-2-furylacrylate-induced mutagenicity in Salmonella typhimurium assay depending on the presence (+Se) or absence of disodium selenite pentahydrate (-Se). The antimutagenicity of MRS(+Se) extract was higher than that of MRS(-Se) extract. Selenium enhanced also the antimutagenic effect of both live and killed cells of E. faecium M-74, respectively. The live bacteria decreased the mutagenicity of selected substances more than killed cells. Synergic activity of selenium with the bacterium was also manifested.

• MeSH
• antimutagenní látky farmakologie   MeSH
• Enterococcus faecium metabolismus   fyziologie   MeSH
• mutageneze účinky léků   MeSH
• mutageny toxicita   MeSH
• probiotika farmakologie   MeSH
• Salmonella typhimurium účinky léků   genetika   MeSH
• selen farmakologie   MeSH
• synergismus léků MeSH
• testy genotoxicity MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antimutagenní látky MeSH
• mutageny MeSH
• selen MeSH

The efficacy of combination therapy with methotrexate (MTX) and probiotic bacteria Enterococcus faecium enriched with organic selenium (EFSe) in rats with adjuvant arthritis was determined. Rats with adjuvant arthritis were given MTX (0.3 mg/kg 2-times weekly, orally); lyophilized E. faecium enriched with Se (15 mg/kg, 5 d per week, orally); and a combination of MTX plus EFSe for a period of 50 d from the immunization. Levels of serum albumin, serum nitrite/nitrate concentrations, changes in hind paw swelling, arthrogram score, bone erosions, whole body bone mineral density (BMD) and bone mineral content (BMC) were assayed in the rats as variables of inflammation and destructive arthritis-associated changes. Treatment with MTX and with the combination MTX + EFSe significantly inhibited markers of both inflammation and arthritis. Significant differences in favor of combination therapy with MTX + EFSe as compared to MTX alone were seen in serum albumin concentration, hind paw swelling and arthrogram score. Reductions in radiographic scores were also more pronounced in the combination therapy group. Combination therapy, but not MTX alone, inhibited the reduction of BMD and BMC; treatment with lyophilized EFSe alone had no significant effect on adjuvant arthritis in rats. The potent therapeutic effect of low dosage MTX therapy in combination with lyophilized EFSe on adjuvant arthritis in rats was shown.

• MeSH
• antirevmatika aplikace a dávkování   terapeutické užití   MeSH
• artritida experimentální terapie   MeSH
• dusičnany krev   MeSH
• dusitany krev   MeSH
• Enterococcus faecium * MeSH
• kombinovaná farmakoterapie MeSH
• kostní denzita MeSH
• krysa rodu Rattus MeSH
• methotrexát aplikace a dávkování   terapeutické užití   MeSH
• noha (od hlezna dolů) patologie   MeSH
• potkani inbrední LEW MeSH
• probiotika aplikace a dávkování   terapeutické užití   MeSH
• revmatoidní artritida terapie   MeSH
• selen aplikace a dávkování   terapeutické užití   MeSH
• výsledek terapie MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antirevmatika MeSH
• dusičnany MeSH
• dusitany MeSH
• methotrexát MeSH
• selen MeSH

The diethyl ether extracts isolated from unfermented milk and milk fermented by Enterococcus faecium exhibited dose-dependent inhibition of mutagenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), nitrovin (NIT), 5-nitro-2-furylacrylic acid (NFA) and UV-irradiation on the Ames bacterial test (Salmonella typhimurium strains TA97 and TA100) and the unicellular flagellate Euglena gracilis. Overall, the fermented milk extract was the most active against UV-irradiation, less active against NIT and MNNG, and the least active against NFA on bacteria. The highest antibleaching effects were observed against MNNG. The differences between antimutagenic effects from fermented and unfermented milk extracts were determined to be statistically significant at the 0.95 CI level.

• MeSH
• akryláty toxicita   MeSH
• antimutagenní látky farmakologie   MeSH
• Enterococcus faecium metabolismus   MeSH
• Euglena gracilis účinky léků   MeSH
• fermentace MeSH
• methylnitronitrosoguanidin toxicita   MeSH
• mléko chemie   metabolismus   MeSH
• mutageneze * MeSH
• nitrofurany toxicita   MeSH
• nitrovin toxicita   MeSH
• Salmonella typhimurium účinky léků   MeSH
• ultrafialové záření MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• akryláty MeSH
• antimutagenní látky MeSH
• methylnitronitrosoguanidin MeSH
• nitrofurany MeSH
• nitrofurylacrylic acid MeSH Prohlížeč
• nitrovin MeSH