Castrated male of European cat, bastard, 16 month-old suffered from a grayish-pink tumour in the anterior chamber of the right eyeball in the course of last six months. After enucleation, the eye was examined by histology, immunohistochemistry (NSE, NPF, S-100 protein) and electronmicroscopy. The tumour was classified as malignant medulloepithelioma. Existence of neuroblastoma in animals and frequency of neuroblastoma and medulloepithelioma in humans and animals is discussed.

• MeSH
• kočky MeSH
• nádory oka patologie   veterinární   MeSH
• nemoci koček patologie   MeSH
• neuroepitelové nádory patologie   veterinární   MeSH
• zvířata MeSH
• Check Tag
• kočky MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

• Klíčová slova
• CAT-SCRATCH DISEASE *, NECK *,
• MeSH
• horní končetina * MeSH
• krk * MeSH
• lidé MeSH
• muskuloskeletální nemoci * MeSH
• nemoc z kočičího škrábnutí * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: Cat scratch disease (CSD), the most common cause of chronic lymphadenopathy among children and adolescents, typically features regional lymphadenitis associated with inoculation site due to a cat scratch or bite. OBJECTIVE: The aim of this study was to systematically review the articles related to CSD which were reported from Turkey in national and international journals in the last 18 years with a pooled-analysis method. METHODS: The articles related to CSD were retrieved by search of four national (Ulakbim Turkish Medical Literature Databases) and three international databases (Pub-Med, Science Citation Index (SCI) and Google scholar). RESULTS: Between the years 1996-2013, CSD cases have been published in a total of 16 articles (4 international, 12 national). These articles which were presented as a case report included a total of 18 CSD cases (38.8% women, 61.2% men; median age 16 years). The most common clinicopathologic subtypes of CSD are regional lymphadenitis (n=9), hepatosplenic (n=3) and neuroretinitis (n=2). The most common complaints of patients were swelling (94.4%), fever (61.2%) and weakness (50%) at admission. On exam, the most common signs were lymphadenopathy (94.4%), fever (61.2%), splenomegaly (16.6%), and skin eruption (16.6%). CONCLUSION: This pooled analysis which enabled the evaluation of a large number of CSD cases, indicated that careful evaluation of clinical findings and histopathological investigation will provide valuable support for diagnosis and treatment of CSD.

• Klíčová slova
• Turkey, cat scratch disease, lymphadenitis,
• MeSH
• dítě MeSH
• kočky MeSH
• lidé MeSH
• mladiství MeSH
• nemoc z kočičího škrábnutí epidemiologie   MeSH
• zvířata MeSH
• Check Tag
• dítě MeSH
• kočky MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Geografické názvy
• Turecko epidemiologie   MeSH

This study describes, for the first time, the relationship between morphology and ploidy in domestic cat embryos. Blastocyst morphology and quality were assessed using time-lapse recordings, while ploidy was analyzed using fluorescence in situ hybridization. Out of 54 blastocysts, clear fluorescence signals for all the molecular probes used were observed in 24 (44.4%) blastocysts, while in another 14 (25.9%) blastocysts, fluorescence signals only allowed for sex assessment. No clear signals were observed in the remaining 16 blastocysts (29.7%). Of the 24 blastocysts with clear signals, normal ploidy was detected in 10 (41.4%), 7 (29.2%) were diagnosed as haploid, and the remaining 7 blastocysts (29.2%) were mosaics. Additionally, results showed the distribution of diploid, haploid, and mosaic blastocysts in relation to the occurrence of morphological disorders and to embryo quality. The presence of abnormal embryo morphology and karyotype disorders may affect further development and the pregnancy rate. Due to the comparable proportion of good and poor quality blastocysts with disturbed ploidy, it is important to implement new methods of embryo assessment, especially when techniques used in humans, such as pronuclear observation, cannot be used.

• Klíčová slova
• Blastocyst, Domestic cat, Fluorescence in situ hybridization (FISH), Morphology, Ploidy, Quality,
• MeSH
• blastocysta * MeSH
• hybridizace in situ fluorescenční veterinární   MeSH
• kočky MeSH
• ploidie * MeSH
• těhotenství MeSH
• úhrn těhotenství na počet žen v reprodukčním věku MeSH
• zvířata MeSH
• Check Tag
• kočky MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

BACKGROUND: A recent study performed on 1.3 million patients showed a strong association between being bitten by a cat and probability of being diagnosed with depression. Authors suggested that infection with cat parasite Toxoplasma could be the reason for this association. METHOD: A cross sectional internet study on a non-clinical population of 5,535 subjects was undertaken. RESULTS: The subjects that reported having been bitten by a dog and a cat or scratched by a cat have higher Beck depression score. They were more likely to have visited psychiatrists, psychotherapists and neurologists in past two years, to have been previously diagnosed with depression (but not with bipolar disorder). Multivariate analysis of models with cat biting, cat scratching, toxoplasmosis, the number of cats at home, and the age of subjects as independent variables showed that only cat scratching had positive effect on depression (p = 0.004). Cat biting and toxoplasmosis had no effect on the depression, and the number of cats at home had a negative effect on depression (p = 0.021). CONCLUSIONS: Absence of association between toxoplasmosis and depression and five times stronger association of depression with cat scratching than with cat biting suggests that the pathogen responsible for mood disorders in animals-injured subjects is probably not the protozoon Toxoplasma gondii but another organism; possibly the agent of cat-scratched disease - the bacteria Bartonella henselae.

• MeSH
• Bartonella henselae fyziologie   MeSH
• deprese mikrobiologie   MeSH
• kočky MeSH
• lidé MeSH
• multivariační analýza MeSH
• nemoc z kočičího škrábnutí mikrobiologie   MeSH
• průřezové studie MeSH
• psi MeSH
• zvířata MeSH
• Check Tag
• kočky MeSH
• lidé MeSH
• mužské pohlaví MeSH
• psi MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

OBJECTIVE: The diagnosis of Bartonella henselae by polymerase chain reaction (PCR) in lymph nodes removed in 10 patients with serologically confirmed evidence cat-scratch disease. MATERIAL AND METHODS: The 2015-2018 group consisted of 10 patients with serologically confirmed cat-scratch disease, all of them having positive IgG antibodies and 6 patients also positive IgM antibodies against B. henselae. The group included 4 men and 6 women, 7 children and 3 adults, aged 5-52 years. Eleven lymph nodes obtained from the 10 patients were formalin-fixed paraffin-embedded. Variants of granulomatous inflammation were found in 9 patients; a 13-year-old boy had Hodgkin's lymphoma. DNA isolation was performed with cobas® DNA Sample Preparation Kit (Roche). DNA of Bartonella spp. was detected by real-time PCR with BactoReal® Kit Bartonella spp. (Ingenetix) detecting the gltA gene specific for the genus Bartonella. RESULTS: Four of the 10 patients tested positive or borderline positive for Bartonella when their histological material was analyzed by PCR. One patient with 2 lymph nodes examined showed a positive result for only 1 lymph node. One adult male had a positive result; three children showed borderline positive results. Of those, two patients had suppurative granulomatous and the other 2 patients had necrotizing suppurative granulomatous inflammation as histological findings. All 4 patients had positive IgM antibodies against B. henselae. The boy with lymphoma had a negative PCR result. CONCLUSION: Serological tests combined with histological examination of lymph nodes and PCR may improve the diagnosis of cat- scratch disease.

• MeSH
• Bartonella henselae * genetika   MeSH
• dítě MeSH
• DNA bakterií genetika   MeSH
• dospělí MeSH
• kvantitativní polymerázová řetězová reakce * MeSH
• lidé MeSH
• lymfatické uzliny mikrobiologie   MeSH
• nemoc z kočičího škrábnutí * diagnóza   mikrobiologie   MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• DNA bakterií MeSH

The cat flea (Ctenocephalides felis) is the most common parasite of domestic cats and dogs worldwide. Due to the morphological ambiguity of C. felis and a lack of - particularly largescale - phylogenetic data, we do not know whether global C. felis populations are morphologically and genetically conserved, or whether human-mediated migration of domestic cats and dogs has resulted in homogenous global populations. To determine the ancestral origin of the species and to understand the level of global pervasion of the cat flea and related taxa, our study aimed to document the distribution and phylogenetic relationships of Ctenocephalides fleas found on cats and dogs worldwide. We investigated the potential drivers behind the establishment of regional cat flea populations using a global collection of fleas from cats and dogs across six continents. We morphologically and molecularly evaluated six out of the 14 known taxa comprising genus Ctenocephalides, including the four original C. felis subspecies (Ctenocephalides felis felis, Ctenocephalides felis strongylus, Ctenocephalides felis orientis and Ctenocephalides felis damarensis), the cosmopolitan species Ctenocephalides canis and the African species Ctenocephalides connatus. We confirm the ubiquity of the cat flea, representing 85% of all fleas collected (4357/5123). Using a multigene approach combining two mitochondrial (cox1 and cox2) and two nuclear (Histone H3 and EF-1α) gene markers, as well as a cox1 survey of 516 fleas across 56 countries, we demonstrate out-of-Africa origins for the genus Ctenocephalides and high levels of genetic diversity within C. felis. We define four bioclimatically limited C. felis clusters (Temperate, Tropical I, Tropical II and African) using maximum entropy modelling. This study defines the global distribution, African origin and phylogenetic relationships of global Ctenocephalides fleas, whilst resolving the taxonomy of the C. felis subspecies and related taxa. We show that humans have inadvertently precipitated the expansion of C. felis throughout the world, promoting diverse population structure and bioclimatic plasticity. By demonstrating the link between the global cat flea communities and their affinity for specific bioclimatic niches, we reveal the drivers behind the establishment and success of the cat flea as a global parasite.

• Klíčová slova
• Cat, Ctenocephalides felis, DNA barcoding, Dog, Niche modelling, Phylogeography, Siphonaptera,
• MeSH
• Ctenocephalides klasifikace   genetika   růst a vývoj   MeSH
• fylogeneze MeSH
• genetické markery MeSH
• infestace blechami parazitologie   veterinární   MeSH
• kočky MeSH
• lidé MeSH
• nemoci koček parazitologie   MeSH
• nemoci psů parazitologie   MeSH
• psi MeSH
• zvířata MeSH
• Check Tag
• kočky MeSH
• lidé MeSH
• mužské pohlaví MeSH
• psi MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Afrika MeSH
• Názvy látek
• genetické markery MeSH

Non-keratinizing squamous cell carcinoma of the trachea was diagnosed in an 11-year-old domestic shorthaired cat suffering from progressive cough and dyspnoea. The tumour was characterized by immunohistochemical expression of cytokeratins and focal expression of vimentin. The cat was exposed historically to high concentrations of environmental cigarette smoke and this may have been a contributory aetiological factor in the genesis of this tumour.

• MeSH
• fatální výsledek MeSH
• keratiny metabolismus   MeSH
• kočky MeSH
• nádorové biomarkery metabolismus   MeSH
• nádory průdušnice etiologie   metabolismus   patologie   veterinární   MeSH
• nemoci koček patologie   MeSH
• spinocelulární karcinom etiologie   metabolismus   patologie   veterinární   MeSH
• znečištění tabákovým kouřem škodlivé účinky   MeSH
• zvířata MeSH
• Check Tag
• kočky MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• keratiny MeSH
• nádorové biomarkery MeSH
• znečištění tabákovým kouřem MeSH

A retrospective evaluation of a group of patients with cat-scratch disease which is focused on epidemiological context, clinical picture, serological diagnosis and treatment in children and adults. Seventy-three patients with catch-scratch disease (CSD) were diagnosed at the Clinic of infectious medicine in 2008-2017, the group consisted of 37 children and 36 adults. Injury, or at least contact with cat, localization of lymph node syndrome and other clinical signs were investigated. Serological diagnosis was based on detection of IgM and IgG antibodies against Bartonella henselae. Duration of lymph node syndrome and antibodies against B. henselae were observed. Findings of granulomatous inflammation in extirpated lymph node supported suspicion of CSD. 66 of 73 patients had contact with cat, only 22 patients reported injury caused by cat. Cervical lymph nodes were affected the most often, in 32 patients. Extirpation of lymph node was performed in 19 patients. Positive IgM antibodies were detected in 47 patients. Between the group of children and adults important differences in any followed parameters were not observed. In the group of 73 patients with cat-scratch disease cervical lymph nodes were affected the most often. Positive IgM antibodies were detected in 47 patients, lymph node extirpation was performed in 19 patients. Considerable differences in course of disease in children and adults were not found out. Keywords: cat-scratch disease, lymph node syndrome, serology, extirpation.

• MeSH
• Bartonella henselae * imunologie   MeSH
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• lymfatické uzliny * imunologie   MeSH
• nemoc z kočičího škrábnutí * komplikace   MeSH
• protilátky bakteriální MeSH
• retrospektivní studie MeSH
• syndrom MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• protilátky bakteriální MeSH

• Klíčová slova
• CAT-SCRATCH DISEASE *,
• MeSH
• lidé MeSH
• nemoc z kočičího škrábnutí * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH