Pankinetoplast DNA structure in a primitive bodonid flagellate, Cryptobia helicis
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
9451008
PubMed Central
PMC1170432
DOI
10.1093/emboj/17.3.838
Knihovny.cz E-zdroje
- MeSH
- elektronová mikroskopie MeSH
- Kinetoplastida genetika ultrastruktura MeSH
- kinetoplastová DNA chemie genetika ultrastruktura MeSH
- konformace nukleové kyseliny MeSH
- kruhová DNA analýza MeSH
- mitochondriální DNA ultrastruktura MeSH
- mitochondrie genetika ultrastruktura MeSH
- protozoální DNA analýza chemie ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- kinetoplastová DNA MeSH
- kruhová DNA MeSH
- mitochondriální DNA MeSH
- protozoální DNA MeSH
The mitochondrial DNA (mtDNA) of a primitive kinetoplastid flagellate Cryptobia helicis is composed of 4.2 kb minicircles and 43 kb maxicircles. 85% and 6% of the minicircles are in the form of supercoiled (SC) and relaxed (OC) monomers, respectively. The remaining minicircles (9%) constitute catenated oligomers composed of both the SC and OC molecules. Minicircles contain bent helix and sequences homologous to the minicircle conserved sequence blocks. Maxicircles encode typical mitochondrial genes and are not catenated. The mtDNA, which we describe with the term 'pankinetoplast DNA', is spread throughout the mitochondrial lumen, where it is associated with multiple electron-lucent loci. There are approximately 8400 minicircles per pankinetoplast-mitochondrion, with the pan-kDNA representing approximately 36% of the total cellular DNA. Based on the similarity of the C.helicis minicircles to plasmids, we present a theory on the formation of the kDNA network.
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