Effects of subinhibitory concentrations of nitroxoline on the surface properties of Escherichia coli
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11501411
DOI
10.1007/bf02818714
Knihovny.cz E-resources
- MeSH
- Bacterial Adhesion drug effects MeSH
- Cell Membrane chemistry drug effects ultrastructure MeSH
- Microscopy, Electron MeSH
- Escherichia coli chemistry drug effects pathogenicity MeSH
- Urinary Tract Infections drug therapy etiology MeSH
- Escherichia coli Infections drug therapy etiology MeSH
- Urinary Catheterization adverse effects MeSH
- Humans MeSH
- Nitroquinolines administration & dosage pharmacology MeSH
- Surface Properties MeSH
- In Vitro Techniques MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Nitroquinolines MeSH
- nitroxoline MeSH Browser
Nitroxoline (5-nitro-8-quinolinol; NIQ) at subinhibitory concentrations (sub-MIC) decreased the adherence of uropathogenic Escherichia coli to catheter surface and significantly enhanced cell surface hydrophobicity. The surface hydrophobicity increased in the presence of sub-MIC of NIQ and also in an excess of Mg2+. The effect of NIQ on the cell surface was not related to the bacteriostatic effect of this agent. The increase in nitrogen and decrease in phosphate content in the cell surface was found in the presence of NIQ. NIQ did not inhibit the expression of fimbriae.
Laboratoire de Microbiologie Faculté de Pharmacie Université Paris XI 92 296 Chátenay Malabry France
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