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Článek

FT
PubMed

Záznam pochází z PubMed

Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice

Infection and immunity. 2003 Apr ; 71 (4) : 2041-6.

Infect Immun
ISSN 0019-9567
Zdroj

Jazyk angličtina Země Spojené státy americké Médium print

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/pmid12654824

Online Plný text

PubMed 12654824
PubMed Central PMC152088
DOI 10.1128/iai.71.4.2041-2046.2003
Knihovny.cz E-zdroje

MeSH
genetická predispozice k nemoci * MeSH
genetická vazba MeSH
genotyp MeSH
hepatomegalie MeSH
inbrední kmeny myší genetika MeSH
křížení genetické MeSH
Leishmania major patogenita MeSH
leishmanióza kožní genetika imunologie patofyziologie MeSH
leishmanióza viscerální genetika imunologie patofyziologie MeSH
mapování chromozomů MeSH
myši inbrední BALB C genetika MeSH
myši MeSH
splenomegalie MeSH
zvířata MeSH
Check Tag
myši MeSH
ženské pohlaví MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

The mouse strains BALB/cHeA (BALB/c) and STS/A (STS) are susceptible and resistant to Leishmania major-induced disease, respectively. We analyzed this difference using recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% genes of the strain STS in a BALB/c background. Previously, testing the resistant strain CcS-5, we found five novel Lmr (Leishmania major response) loci, each associated with a different combination of pathological and immunological reactions. Here we analyze the response of RC strain CcS-16, which is even more susceptible to L. major than BALB/c. In the (CcS-16 x BALB/c)F(2) hybrids we mapped three novel loci that influence cutaneous or visceral pathology. Lmr14 (chromosome 2) controls splenomegaly and hepatomegaly. On the other hand Lmr15 (chromosome 11) determines hepatomegaly only, and Lmr13 (chromosome 18) determines skin lesions only. These data confirm the complex control of L. major-induced pathology, where cutaneous and visceral pathology are controlled by different combinations of genes. It indicates organ-specific control of antiparasite responses. The definition of genes controlling these responses will permit a better understanding of pathways and genetic diversity underlying the different disease phenotypes.

Institute of Molecular Genetics Academy of Sciences of the Czech Republic Fleming nám 2 166 37 Prague 6 Czech Republic

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