The effect of different antioxidants on nitric oxide production in hypertensive rats
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Antihypertensive Agents pharmacology MeSH
- Antioxidants pharmacology MeSH
- Hypertension metabolism MeSH
- Rats MeSH
- Models, Animal MeSH
- Nitric Oxide biosynthesis MeSH
- Oxidation-Reduction MeSH
- Protein Isoforms metabolism MeSH
- Reactive Oxygen Species metabolism MeSH
- Free Radical Scavengers MeSH
- Nitric Oxide Synthase metabolism MeSH
- Free Radicals metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Antihypertensive Agents MeSH
- Antioxidants MeSH
- Nitric Oxide MeSH
- Protein Isoforms MeSH
- Reactive Oxygen Species MeSH
- Free Radical Scavengers MeSH
- Nitric Oxide Synthase MeSH
- Free Radicals MeSH
The imbalance between nitric oxide (NO) and reactive oxygen species (ROS) production appears to be a common feature of experimental and human hypertension. Previously, different antioxidants and/or scavengers of oxygen free radicals were shown to activate nitric oxide synthase (NO synthase, NOS) and to increase the expression of both endothelial and neuronal NO synthase isoforms leading to blood pressure reduction. On the other hand, various antihypertensive drugs have been documented to possess antioxidant properties, which may contribute to their beneficial effect on blood pressure. This review is focused on the effects of antioxidant treatment in different models of experimental hypertension with a special attention to the prevention of oxidative damage and the augmentation of NO synthase activity and expression of NOS isoforms.
References provided by Crossref.org
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