Five geranylflavonoids, one prenylated flavonoid, and a simple flavanone were isolated from an ethanolic extract of Paulownia tomentosa fruit. Tomentodiplacol (1), 3'-O-methyl-5'-methoxydiplacol (2), 6-isopentenyl-3'-O-methyltaxifolin (3), and dihydrotricin (4) are reported from a natural source for the first time and 3'-O-methyldiplacone (6) for the first time from the genus Paulownia. The structures of the compounds were determined by mass spectrometry, including HRMS, and by 1D and 2D NMR spectroscopy. The cytotoxicity and DPPH (2,2-diphenyl-1-picrylhydrazyl)-quenching activity of some of these compounds were tested, with diplacone proving to be the best antioxidant, although the most cytotoxic compound.

Department of Natural Drugs University of Veterinary and Pharmaceutical Sciences Brno Palackého 1 3 CZ 612 42 Brno Czech Republic

Citace poskytuje Crossref.org

Prenylated Flavonoids in Topical Infections and Wound Healing

Direct and Indirect Antioxidant Effects of Selected Plant Phenolics in Cell-Based Assays

Screening of Natural Compounds as P-Glycoprotein Inhibitors against Multidrug Resistance

Phytochemical profile of Paulownia tomentosa (Thunb). Steud

Antiradical and cytoprotective activities of several C-geranyl-substituted flavanones from Paulownia tomentosa fruit

Antiradical activity of Paulownia tomentosa (Scrophulariaceae) extracts