Metallothioneins and zinc in cancer diagnosis and therapy
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- MeSH
- antitumorózní látky terapeutické užití MeSH
- apoptóza účinky léků MeSH
- cílená molekulární terapie MeSH
- imunomodulace MeSH
- lidé MeSH
- metalothionein antagonisté a inhibitory krev metabolismus MeSH
- nádorové biomarkery krev metabolismus MeSH
- nádorové proteiny antagonisté a inhibitory krev metabolismus MeSH
- nádory diagnóza farmakoterapie imunologie metabolismus MeSH
- oxid dusnatý metabolismus MeSH
- oxidační stres účinky léků MeSH
- prognóza MeSH
- proliferace buněk účinky léků MeSH
- zinek škodlivé účinky nedostatek metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- antitumorózní látky MeSH
- metalothionein MeSH
- nádorové biomarkery MeSH
- nádorové proteiny MeSH
- oxid dusnatý MeSH
- zinek MeSH
Metallothioneins (MTs) are involved in protection against oxidative stress (OS) and toxic metals and they participate in zinc metabolism and its homeostasis. Disturbing of zinc homeostasis can lead to formation of reactive oxygen species, which can result in OS causing alterations in immunity, aging, and civilization diseases, but also in cancer development. It is not surprising that altered zinc metabolism and expression of MTs are of great interest in the case of studying of oncogenesis and cancer prognosis. The role of MTs and zinc in cancer development is tightly connected, and the structure and function of MTs are strongly dependent on Zn²⁺ redox state and its binding to proteins. Antiapoptic effects of MTs and their interactions with proteins nuclear factor kappa B, protein kinase C, esophageal cancer-related gene, and p53 as well as the role of MTs in their proliferation, immunomodulation, enzyme activation, and interaction with nitric oxide are reviewed. Utilization of MTs in cancer diagnosis and therapy is summarized and their importance for chemoresistance is also mentioned.
Citace poskytuje Crossref.org
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