Metallothioneins and zinc in cancer diagnosis and therapy
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Apoptosis drug effects MeSH
- Molecular Targeted Therapy MeSH
- Immunomodulation MeSH
- Humans MeSH
- Metallothionein antagonists & inhibitors blood metabolism MeSH
- Biomarkers, Tumor blood metabolism MeSH
- Neoplasm Proteins antagonists & inhibitors blood metabolism MeSH
- Neoplasms diagnosis drug therapy immunology metabolism MeSH
- Nitric Oxide metabolism MeSH
- Oxidative Stress drug effects MeSH
- Prognosis MeSH
- Cell Proliferation drug effects MeSH
- Antineoplastic Agents therapeutic use MeSH
- Zinc adverse effects deficiency metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Metallothionein MeSH
- Biomarkers, Tumor MeSH
- Neoplasm Proteins MeSH
- Nitric Oxide MeSH
- Antineoplastic Agents MeSH
- Zinc MeSH
Metallothioneins (MTs) are involved in protection against oxidative stress (OS) and toxic metals and they participate in zinc metabolism and its homeostasis. Disturbing of zinc homeostasis can lead to formation of reactive oxygen species, which can result in OS causing alterations in immunity, aging, and civilization diseases, but also in cancer development. It is not surprising that altered zinc metabolism and expression of MTs are of great interest in the case of studying of oncogenesis and cancer prognosis. The role of MTs and zinc in cancer development is tightly connected, and the structure and function of MTs are strongly dependent on Zn²⁺ redox state and its binding to proteins. Antiapoptic effects of MTs and their interactions with proteins nuclear factor kappa B, protein kinase C, esophageal cancer-related gene, and p53 as well as the role of MTs in their proliferation, immunomodulation, enzyme activation, and interaction with nitric oxide are reviewed. Utilization of MTs in cancer diagnosis and therapy is summarized and their importance for chemoresistance is also mentioned.
References provided by Crossref.org
Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells
Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery
Zinc and zinc-containing biomolecules in childhood brain tumors
The Zinc-Schiff Base-Novicidin Complex as a Potential Prostate Cancer Therapy
Metallothionein - immunohistochemical cancer biomarker: a meta-analysis
The role of metallothionein in oxidative stress
