Infections with the tick-borne bacterium "Candidatus Neoehrlichia mikurensis" mimic noninfectious conditions in patients with B cell malignancies or autoimmune diseases
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24647019
DOI
10.1093/cid/ciu189
PII: ciu189
Knihovny.cz E-zdroje
- Klíčová slova
- B-cell malignancies, human, infection, Neoehrlichia, tick-borne,
- MeSH
- aneurysma mikrobiologie MeSH
- antibakteriální látky terapeutické užití MeSH
- autoimunitní nemoci mikrobiologie MeSH
- C-reaktivní protein metabolismus MeSH
- DNA bakterií krev MeSH
- hematologické nádory mikrobiologie MeSH
- horečka mikrobiologie MeSH
- infekce bakteriemi čeledi Anaplasmataceae komplikace diagnóza farmakoterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- muskuloskeletální bolest mikrobiologie MeSH
- nemoci přenášené klíšťaty komplikace diagnóza farmakoterapie mikrobiologie MeSH
- objevující se infekční nemoci diagnóza farmakoterapie mikrobiologie MeSH
- opožděná diagnóza MeSH
- plicní embolie mikrobiologie MeSH
- senioři MeSH
- splenektomie MeSH
- tranzitorní ischemická ataka mikrobiologie MeSH
- žilní trombóza mikrobiologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antibakteriální látky MeSH
- C-reaktivní protein MeSH
- DNA bakterií MeSH
BACKGROUND: Candidatus Neoehrlichia mikurensis is a newly discovered noncultivatable bacterium spread among ticks and rodents in Europe and Asia that can infect humans, particularly immunocompromised patients. METHODS: We compiled clinical and laboratory data from 11 patients with hematological malignances or autoimmune diseases who were diagnosed with Candidatus N. mikurensis infection in Europe 2010-2013. Both published (6) and unpublished cases (5) were included. RESULTS: The patients had a median age of 67, were mostly male (8/11), and resided in Sweden, Switzerland, Germany, and the Czech Republic. All but one had ongoing or recent immune suppressive treatment and a majority were splenectomized (8/11). Less than half of them recalled tick exposure. The most frequent symptoms were fever (11/11), localized pain afflicting muscles and/or joints (8/11), vascular and thromboembolic events (6/11), that is, deep vein thrombosis (4), transitory ischemic attacks (2), pulmonary embolism (1), and arterial aneurysm (1). Typical laboratory findings were elevated C-reactive protein, leukocytosis with neutrophilia, and anemia. Median time from onset of symptoms to correct diagnosis was 2 months. In at least 4 cases, the condition was interpreted to be due to the underlying disease, and immunosuppressive therapy was scheduled. All patients recovered completely when doxycycline was administered. CONCLUSIONS: Candidatus N. mikurensis is an emerging tick-borne pathogen that may give rise to a systemic inflammatory syndrome in persons with hematologic or autoimmune diseases that could be mistaken for recurrence of the underlying disease and/or unrelated arteriosclerotic vascular events. Awareness of this new pathogen is warranted among rheumatologists, hematologists, oncologists, and infectious disease specialists.
Department of Hematology and Coagulation Sahlgrenska University Hospital Göteborg
Department of Internal Medicine Karlstad Hospital Karlstad
Department of Medicine Kungälv Hospital Kungälv Sweden
Department of Rheumatology Sahlgrenska University Hospital Göteborg
Institute of Medical Microbiology University of Zurich Zurich Switzerland
Laboratory for Molecular Diagnostics CHAMBON Laboratories Prague Czech Republic
Citace poskytuje Crossref.org
Putative morphology of Neoehrlichia mikurensis in salivary glands of Ixodes ricinus
Multilocus Sequence Analysis of Clinical "Candidatus Neoehrlichia mikurensis" Strains from Europe
