Renaissance of mammalian endogenous RNAi
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24873877
DOI
10.1016/j.febslet.2014.05.030
PII: S0014-5793(14)00417-7
Knihovny.cz E-resources
- Keywords
- Dicer, Oocyte, RNAi, Retrotransposon, Virus,
- MeSH
- Humans MeSH
- RNA, Small Interfering genetics metabolism MeSH
- RNA Interference * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- RNA, Small Interfering MeSH
RNA interference (RNAi) denotes sequence-specific mRNA degradation induced by long double-stranded RNA (dsRNA). RNAi is an ancient eukaryotic defense mechanism against viruses and mobile elements. In mammals, endogenous RNAi was outstripped during evolution by the current innate and acquired immunity. The RNAi apparatus, which remains essentially intact, serves mostly the microRNA pathway, which regulates endogenous gene expression. Remarkably, several recent publications brought the mammalian endogenous RNAi pathway back into the spotlight. Here, I will provide an up-to-date review of the mammalian endogenous RNAi pathway with a focus on its defensive role and overlaps with miRNA and piRNA pathways.
References provided by Crossref.org
CRISPR-Induced Expression of N-Terminally Truncated Dicer in Mouse Cells
Key Mechanistic Principles and Considerations Concerning RNA Interference
Epigenetic Regulation in Etiology of Type 1 Diabetes Mellitus
Restricted and non-essential redundancy of RNAi and piRNA pathways in mouse oocytes
Main constraints for RNAi induced by expressed long dsRNA in mouse cells
Production of small RNAs by mammalian Dicer
