The modulation of carbonyl reductase 1 by polyphenols
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- Klíčová slova
- Flavonoids, curcuminoids, induction, inhibition, polymorphism, stilbenes,
- MeSH
- alkoholoxidoreduktasy antagonisté a inhibitory biosyntéza genetika metabolismus MeSH
- bupropion metabolismus MeSH
- butanony metabolismus MeSH
- butyrofenony metabolismus MeSH
- chinoliziny metabolismus MeSH
- daunomycin metabolismus MeSH
- doxorubicin metabolismus MeSH
- fenylpropionáty metabolismus MeSH
- haloperidol metabolismus MeSH
- indoly metabolismus MeSH
- lidé MeSH
- nabumeton MeSH
- nádory enzymologie MeSH
- polyfenoly farmakologie MeSH
- regulace genové exprese enzymů MeSH
- substrátová specifita MeSH
- xenobiotika metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- alkoholoxidoreduktasy MeSH
- bupropion MeSH
- butanony MeSH
- butyrofenony MeSH
- CBR1 protein, human MeSH Prohlížeč
- chinoliziny MeSH
- daunomycin MeSH
- dolasetron MeSH Prohlížeč
- doxorubicin MeSH
- fenylpropionáty MeSH
- haloperidol MeSH
- indoly MeSH
- loxoprofen MeSH Prohlížeč
- nabumeton MeSH
- polyfenoly MeSH
- timiperone MeSH Prohlížeč
- xenobiotika MeSH
Carbonyl reductase 1 (CBR1), an enzyme belonging to the short-chain dehydrogenases/reductases family, has been detected in all human tissues. CBR1 catalyzes the reduction of many xenobiotics, including important drugs (e.g. anthracyclines, nabumetone, bupropion, dolasetron) and harmful carbonyls and quinones. Moreover, it participates in the metabolism of a number of endogenous compounds and it may play a role in certain pathologies. Plant polyphenols are not only present in many human food sources, but are also a component of many popular dietary supplements and herbal medicines. Many studies reviewed herein have demonstrated the potency of certain flavonoids, stilbenes and curcuminoids in the inhibition of the activity of CBR1. Interactions of these polyphenols with transcriptional factors, which regulate CBR1 expression, have also been reported in several studies. As CBR1 plays an important role in drug metabolism as well as in the protection of the organism against potentially harmful carbonyls, the modulation of its expression/activity may have significant pharmacological and/or toxicological consequences. Some polyphenols (e.g. luteolin, apigenin and curcumin) have been shown to be very potent CBR1 inhibitors. The inhibition of CBR1 seems useful regarding the increased efficacy of anthracycline therapy, but it may cause the worse detoxification of reactive carbonyls. Nevertheless, all known information about the interactions of polyphenols with CBR1 have only been based on the results of in vitro studies. With respect to the high importance of CBR1 and the frequent consumption of polyphenols, in vivo studies would be very helpful for the evaluation of risks/benefits of polyphenol interactions with CBR1.
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