The interplay between biological and physical scenarios of bacterial death induced by non-thermal plasma
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26761777
DOI
10.1016/j.biomaterials.2015.12.027
PII: S0142-9612(15)01015-7
Knihovny.cz E-resources
- Keywords
- Apoptosis, Bacteria, Bacterial inactivation, Cytotoxicity, Non-thermal plasma, Reactive oxygen species (ROS),
- MeSH
- Anti-Infective Agents administration & dosage MeSH
- Apoptosis drug effects physiology MeSH
- Bacteria cytology drug effects MeSH
- Cell Membrane drug effects physiology MeSH
- Bacterial Physiological Phenomena drug effects MeSH
- Plasma Gases administration & dosage MeSH
- Reactive Oxygen Species metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Infective Agents MeSH
- Plasma Gases MeSH
- Reactive Oxygen Species MeSH
Direct interactions of plasma matter with living cells and tissues can dramatically affect their functionality, initiating many important effects from cancer elimination to bacteria deactivation. However, the physical mechanisms and biochemical pathways underlying the effects of non-thermal plasma on bacteria and cell fate have still not been fully explored. Here, we report on the molecular mechanisms of non-thermal plasma-induced bacteria inactivation in both Gram-positive and Gram-negative strains. We demonstrate that depending on the exposure time plasma induces either direct physical destruction of bacteria or triggers programmed cell death (PCD) that exhibits characteristic features of apoptosis. The interplay between physical disruption and PCD is on the one hand driven by physical plasma parameters, and on the other hand by biological and physical properties of bacteria. The explored possibilities of the tuneable bacteria deactivation provide a basis for the development of advanced plasma-based therapies. To a great extent, our study opens new possibilities for controlled non-thermal plasma interactions with living systems.
Institute of Experimental Medicine AS CR Prague Czech Republic
References provided by Crossref.org
Non-thermal Plasma Treatment of ESKAPE Pathogens: A Review
Inactivation of Schistosoma Using Low-Temperature Plasma
Inactivation of Dermatophytes Causing Onychomycosis and Its Therapy Using Non-Thermal Plasma
Critical Analysis of Non-Thermal Plasma-Driven Modulation of Immune Cells from Clinical Perspective
Medically important biofilms and non-thermal plasma
Chemically different non-thermal plasmas target distinct cell death pathways
Non-thermal air plasma promotes the healing of acute skin wounds in rats
