The interplay between biological and physical scenarios of bacterial death induced by non-thermal plasma
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26761777
DOI
10.1016/j.biomaterials.2015.12.027
PII: S0142-9612(15)01015-7
Knihovny.cz E-zdroje
- Klíčová slova
- Apoptosis, Bacteria, Bacterial inactivation, Cytotoxicity, Non-thermal plasma, Reactive oxygen species (ROS),
- MeSH
- antiinfekční látky aplikace a dávkování MeSH
- apoptóza účinky léků fyziologie MeSH
- Bacteria cytologie účinky léků MeSH
- buněčná membrána účinky léků fyziologie MeSH
- fyziologie bakterií účinky léků MeSH
- plazmové plyny aplikace a dávkování MeSH
- reaktivní formy kyslíku metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antiinfekční látky MeSH
- plazmové plyny MeSH
- reaktivní formy kyslíku MeSH
Direct interactions of plasma matter with living cells and tissues can dramatically affect their functionality, initiating many important effects from cancer elimination to bacteria deactivation. However, the physical mechanisms and biochemical pathways underlying the effects of non-thermal plasma on bacteria and cell fate have still not been fully explored. Here, we report on the molecular mechanisms of non-thermal plasma-induced bacteria inactivation in both Gram-positive and Gram-negative strains. We demonstrate that depending on the exposure time plasma induces either direct physical destruction of bacteria or triggers programmed cell death (PCD) that exhibits characteristic features of apoptosis. The interplay between physical disruption and PCD is on the one hand driven by physical plasma parameters, and on the other hand by biological and physical properties of bacteria. The explored possibilities of the tuneable bacteria deactivation provide a basis for the development of advanced plasma-based therapies. To a great extent, our study opens new possibilities for controlled non-thermal plasma interactions with living systems.
Institute of Experimental Medicine AS CR Prague Czech Republic
Citace poskytuje Crossref.org
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