A novel multistep method for chondroitin sulphate immobilization and its interaction with fibroblast cells
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
27770972
DOI
10.1016/j.msec.2016.08.065
PII: S0928-4931(16)30980-8
Knihovny.cz E-resources
- Keywords
- Polyethylene, chondroitin sulphate, fibroblast, plasma treatment, surface modification,
- MeSH
- Chondroitin Sulfates chemistry pharmacology MeSH
- Fibroblasts cytology drug effects MeSH
- Photoelectron Spectroscopy MeSH
- Microscopy, Atomic Force MeSH
- Mice MeSH
- Cell Proliferation drug effects MeSH
- Cattle MeSH
- Wettability MeSH
- Spectroscopy, Fourier Transform Infrared MeSH
- Cell Shape drug effects MeSH
- Water chemistry MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Cattle MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Chondroitin Sulfates MeSH
- Water MeSH
Polymeric biomaterials are widely used in medical applications owing to their low cost, processability and sufficient toughness. Surface modification by creating a thin film of bioactive agents is promising technique to enhance cellular interactions, regulate the protein adsorption and/or avoid bacterial infections. Polyethylene is one of the most used polymeric biomaterial but its hydrophobic nature impedes its further chemical modifications. Plasma treatment is unique method to increase its hydrophilicity by incorporating hydrophilic oxidative functional groups and tailoring the surface by physical etching. Furthermore, grafting of polymer brushes of amine group containing monomers onto the functionalized surface lead to strongly immobilized bioactive agents at the final step. Chondroitin sulphate is natural polysaccharide mainly found in connective cartilage tissue which used as a bioactive agent to immobilize onto polyethylene surface by multistep method in this study.
References provided by Crossref.org
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