JavaScript is NOT enabled !

Please enable JavaScript.

Article

PubMed

This record comes from PubMed

The effect of Alzheimer's disease on spatial navigation strategies

Parizkova, Martina
Author Parizkova, Martina Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
Lerch, Ondrej
Author Lerch, Ondrej Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
Moffat, Scott Douglas
Author Moffat, Scott Douglas School of Psychology, Georgia Institute of Technology, Atlanta, GA, USA
Andel, Ross
Author Andel, Ross International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic; School of Aging Studies, University of South Florida, Tampa, FL, USA
Mazancova, Adela Fendrych
Author Mazancova, Adela Fendrych Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
Nedelska, Zuzana
Author Nedelska, Zuzana Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
Vyhnalek, Martin
Author Vyhnalek, Martin Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
Hort, Jakub
Author Hort, Jakub Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
Laczó, Jan
Author Laczó, Jan Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. Electronic address: JanLaczo@gmail.com

Neurobiology of aging. 2018 Apr ; 64 () : 107-115. [epub] 20171229

Neurobiol Aging
ISSN 1558-1497 | 0197-4580
Source

Language English Country United States Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid29358117

PubMed 29358117
DOI 10.1016/j.neurobiolaging.2017.12.019
PII: S0197-4580(17)30416-5
Knihovny.cz E-resources

Keywords
Allocentric, Basal forebrain, Egocentric, Hippocampus, Mild cognitive impairment, Navigation, Strategy,
MeSH
Alzheimer Disease pathology psychology MeSH
Atrophy MeSH
Maze Learning MeSH
Nerve Degeneration MeSH
Hippocampus pathology physiopathology MeSH
Cognitive Dysfunction pathology psychology MeSH
Middle Aged MeSH
Humans MeSH
Neuropsychological Tests MeSH
Basal Forebrain pathology physiopathology MeSH
Spatial Navigation physiology MeSH
Aged, 80 and over MeSH
Aged MeSH
Severity of Illness Index MeSH
Organ Size MeSH
Check Tag
Middle Aged MeSH
Humans MeSH
Male MeSH
Aged, 80 and over MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH

Hippocampal and basal forebrain (BF) atrophy is associated with allocentric navigation impairment in Alzheimer's disease (AD) and may lead to recruitment of compensatory navigation strategies. We examined navigation strategy preference, its association with allocentric navigation, and the role of hippocampal and BF volumes in this association in early clinical stages of AD. Sixty nine participants-amnestic mild cognitive impairment (aMCI) due to AD (n = 28), AD dementia (n = 21), and cognitively normal (CN) older adults (n = 20)-underwent virtual Y-maze strategy assessment, real-space navigation testing, cognitive assessment, and hippocampal and BF volumetry. Preference for egocentric over allocentric strategy increased with AD severity (aMCI: 67% vs. 33%; dementia: 94% vs. 6%), which contrasted with preference in the CN group (39% vs. 61%). Those with aMCI who preferred egocentric strategy had worse allocentric navigation. Among those with aMCI, hippocampal and BF atrophy explained up to 25% of the association between strategy preference and allocentric navigation. The preference for egocentric strategy in AD may reflect recruitment of compensatory extrahippocampal navigation strategies as adaptation to hippocampal and BF neurodegeneration.

International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic; School of Aging Studies University of South Florida Tampa FL USA

Memory Clinic Department of Neurology Charles University 2nd Faculty of Medicine and Motol University Hospital Prague Czech Republic

Memory Clinic Department of Neurology Charles University 2nd Faculty of Medicine and Motol University Hospital Prague Czech Republic; International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic

School of Psychology Georgia Institute of Technology Atlanta GA USA

References provided by Crossref.org

Newest 20 citations...

See more in
Medvik | PubMed

Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype

Journal of neurology. 2025 Jun 02 ; 272 (6) : 438. [epub] 20250602

J Neurol
ISSN 1432-1459 | 0340-5354
Source

Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease

iScience. 2024 Jun 21 ; 27 (6) : 109832. [epub] 20240426