Mannose Receptor and the Mystery of Nonhealing Leishmania major Infection
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Comment
PubMed
29650366
DOI
10.1016/j.pt.2018.03.006
PII: S1471-4922(18)30063-1
Knihovny.cz E-resources
- MeSH
- Interferon-gamma MeSH
- Leishmania major * MeSH
- Leishmaniasis, Cutaneous * MeSH
- Lectins, C-Type MeSH
- Mannose-Binding Lectins MeSH
- Humans MeSH
- Mannose Receptor MeSH
- Receptors, Cell Surface MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Comment MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Interferon-gamma MeSH
- Lectins, C-Type MeSH
- Mannose-Binding Lectins MeSH
- Mannose Receptor MeSH
- Receptors, Cell Surface MeSH
Scientists have long puzzled over the ability of Leishmania major Seidman (LmSd) to form nonhealing cutaneous lesions in the face of a strong Th1 response. A recent study identified a population of dermal macrophages that are preferentially infected by LmSd in a mannose receptor 1-, C-type 1 (MRC1/CD206)-dependent manner.
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