Decarboxylative Organocatalytic Allylic Amination of Morita-Baylis-Hillman Carbamates
Status PubMed-not-MEDLINE Language English Country Germany Media print-electronic
Document type Journal Article
Grant support
16-23597S
Grantová Agentura České Republiky
18-11851S
Grantová Agentura České Republiky
1504217
Grantová Agentura, Univerzita Karlova
- Keywords
- Brønsted acid, allylic compounds, chirality, cinchona alkaloids, enantioselective allylic amination,
- Publication type
- Journal Article MeSH
The present study reports the organocatalytic enantioselective allylic amination of Morita-Baylis-Hillman carbamates efficiently catalyzed by a chiral amine in the presence of a Brønsted acid. Chiral allylic amines were produced in high yields (up to 98 %) and enantioselectivities (up to 97 % ee). This method provides an efficient and easily performed route to prepare α-methylene-β-lactams, and other optically active β-lactams, such as the cholesterol-lowering drug Ezetimibe.
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