Activities of mitochondrial respiratory chain complexes in platelets of patients with Alzheimer's disease and depressive disorder
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
31377247
DOI
10.1016/j.mito.2019.07.013
PII: S1567-7249(18)30110-7
Knihovny.cz E-resources
- Keywords
- Alzheimer's disease, Citrate synthase, Coenzyme Q(10), Depressive disorder, Mitochondria, Respiratory complex,
- MeSH
- Alzheimer Disease metabolism MeSH
- Biomarkers metabolism MeSH
- Depressive Disorder, Major metabolism MeSH
- Adult MeSH
- Electron Transport Chain Complex Proteins metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Mitochondrial Membranes metabolism MeSH
- Mitochondria metabolism MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Electron Transport physiology MeSH
- Blood Platelets metabolism MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- Electron Transport Chain Complex Proteins MeSH
We analyzed activities of complex I, II, III, and IV, and citrate synthase (CS) in patients with major depressive disorder (MDD) or Alzheimer's disease (AD) presenting with or without depression. Associations of these parameters with disease or disease severity were observed in both AD and MDD; however, mean values of mitochondrial parameters were significantly altered in AD but not in MDD. Potential mitochondrial dysfunction in MDD seems not to be caused by disturbed activity of CS or respiratory complexes. In AD, a decrease in the activity of CS and complex IV may cause mitochondrial dysfunction, whereas an increase in activities of other mitochondrial complexes or their ratios to CS may be an adaptive response. The data indicate that comorbid depression in AD is associated with increased complex II activity. The mitochondrial parameters measured can be included in the panel of biomarkers of AD.
References provided by Crossref.org
CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease
Coenzyme Q10: A Biomarker in the Differential Diagnosis of Parkinsonian Syndromes
Age-Dependent Alterations in Platelet Mitochondrial Respiration
Coenzyme Q10 effects in neurological diseases
Effect of Novel Antipsychotics on Energy Metabolism - In Vitro Study in Pig Brain Mitochondria
Measurement of Mitochondrial Respiration in Platelets
