An increasing interest in a healthy lifestyle raises questions about optimal body weight. Evidently, it should be clearly discriminated between the standardised "normal" body weight and individually optimal weight. To this end, the basic principle of personalised medicine "one size does not fit all" has to be applied. Contextually, "normal" but e.g. borderline body mass index might be optimal for one person but apparently suboptimal for another one strongly depending on the individual genetic predisposition, geographic origin, cultural and nutritional habits and relevant lifestyle parameters-all included into comprehensive individual patient profile. Even if only slightly deviant, both overweight and underweight are acknowledged risk factors for a shifted metabolism which, if being not optimised, may strongly contribute to the development and progression of severe pathologies. Development of innovative screening programmes is essential to promote population health by application of health risks assessment, individualised patient profiling and multi-parametric analysis, further used for cost-effective targeted prevention and treatments tailored to the person. The following healthcare areas are considered to be potentially strongly benefiting from the above proposed measures: suboptimal health conditions, sports medicine, stress overload and associated complications, planned pregnancies, periodontal health and dentistry, sleep medicine, eye health and disorders, inflammatory disorders, healing and pain management, metabolic disorders, cardiovascular disease, cancers, psychiatric and neurologic disorders, stroke of known and unknown aetiology, improved individual and population outcomes under pandemic conditions such as COVID-19. In a long-term way, a significantly improved healthcare economy is one of benefits of the proposed paradigm shift from reactive to Predictive, Preventive and Personalised Medicine (PPPM/3PM). A tight collaboration between all stakeholders including scientific community, healthcare givers, patient organisations, policy-makers and educators is essential for the smooth implementation of 3PM concepts in daily practice.

AMEOS Clinical Centre for Psychiatry and Psychotherapy 31135 Hildesheim Germany

Biomedical Centre Faculty of Medicine in Pilsen Charles University Staré Město Czech Republic

Bonn Aachen International Centre for IT Rheinische Friedrich Wilhelms Universität Bonn 53115 Bonn Germany

Clinic of Obstetrics and Gynaecology Jessenius Faculty of Medicine Comenius University in Bratislava 03601 Martin Slovakia

Department of Bioinformatics Fraunhofer Institute for Algorithms and Scientific Computing Schloss Birlinghoven 53757 Sankt Augustin Germany

Department of Biomedical Engineering Faculty of Fundamental Problems of Technology Wrocław University of Science and Technology 50 370 Wrocław Poland

Department of Histology and Embryology Faculty of Medicine in Pilsen Charles University Staré Město Czech Republic

Department of Medical Biology Jessenius Faculty of Medicine Comenius University in Bratislava 03601 Martin Slovakia

Department of Neurology Faculty of Medicine in Pilsen Charles University and University Hospital Pilsen Pilsen Czech Republic

Departments of Maxillofacial Surgery and Hospital Dentistry Voronezh N N Burdenko State Medical University Voronezh Russian Federation

European Depression Association Brussels Belgium

Fachklinik Kinder und Jugendliche Psychiatrie AMEOS Klinikum Hildesheim Akademisches Lehrkrankenhaus für Pflege der FOM Hochschule Essen Hildesheim Germany

Institute of Psychology Department of Clinical Psychology 2 University of Innsbruck Innsbruck Austria

NeuroCure Clinical Research Centre Experimental and Clinical Research Centre Max Delbrueck Centre for Molecular Medicine and Charité Universitaetsmedizin Berlin Berlin Germany

Nutrition Department Ashkelon Academic College Ashkelon Tel Aviv Israel

Predictive Preventive and Personalised Medicine Department of Radiation Oncology University Hospital Bonn Rheinische Friedrich Wilhelms Universität Bonn 53127 Bonn Germany

Private Institute of Applied Ophthalmology Berlin Germany

Stavropol State Medical University Stavropol Russian Federation

UCB Biosciences GmbH Alfred Nobel Str 10 40789 Monheim am Rhein Germany

Ultrasound Department Clinical Hospital Pheophania Kyiv Ukraine

Weill Cornell Medicine Qatar Education City Qatar Foundation 24144 Doha Qatar

Zabolotny Institute of Microbiology and Virology National Academy of Sciences of Ukraine Kyiv Ukraine

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Aronia melanocarpa L. fruit peels show anti-cancer effects in preclinical models of breast carcinoma: The perspectives in the chemoprevention and therapy modulation

The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation

Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells - A potential contribution to the predictive, preventive, and personalized medicine

Therapy-resistant breast cancer in focus: Clinically relevant mitigation by flavonoids targeting cancer stem cells

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management-Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

Ischemic stroke of unclear aetiology: a case-by-case analysis and call for a multi-professional predictive, preventive and personalised approach

Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care