At present, asymmetric hydrogenation is an attractive method for the synthesis of enantioenriched chiral compounds, such as drugs, agrochemicals or fragrances. This review is focused on the asymmetric transfer hydrogenation (ATH) of imines, in particular 3,4-dihydroisoquinolines. Mechanistic aspects of ATH are discussed and analytical methods for the monitoring of ATH as developed in our group are presented. The effect of structural changes of the catalyst and substrate on the course of ATH is also described. The influence of temperature, reactant concentrations and other reaction parameters as well as the utilizability of ATH in chemical industry are discussed.
The integrity of film-coated tablets may be a crucial factor for their long-term stability as well as for their desirable action in the digestive tract. Consequently, nondestructive and sensitive tests are very important for quality control of the film-coated tablets. The quasi- stationary permeation of inert gases through the tablets was proposed as a new fast and inexpensive test of the integrity of filmcoated tablets. Using the commercial coating material Opadry® and alternative coating materials, the sensitivity to the test of the coating composition and to local damage of the tablets by mechanical stress was demonstrated.
The work deals with preparation and characterization of polymer immunoparticles used as a separation tool for biomarkers from biological fluids like urine, plasma etc. Polymer imunoparticles consist of antibodies immobilized in a polyvinyl alcohol and polyethylene glycol matrix. Prepared immunoparticles, containing monoclonal antibodies against 8-iso Prostaglandin F2α, were used as a tool for a preliminary separation of 8-iso Prostaglandin F2α (a marker of oxidative stress) from complex biological matrix (urine) before a highly specific and precise detection and quantification by LC-ESI-MS method. The deve¬loped method was characterized by high precision and accuracy. Functionality of the method was tested in a clinical study where urine concentration levels of 8-iso Prostaglandin F2α in patients with diagnosis of asbestosis or silicosis (oxidative stress induced diseases) and control group were compared.
Economic consequences of restrictions resulting from legislative requirements imposed on the product and its production safety as well as of the restrictions relting from the requirements of the public from the plant neighbourhood for its operation. The possibilities of affecting the restrictions by the producers are discussed. Specific examples of activities of chemical producers in the Czech Republic aimed at forming relations without conflicts of the company and people in the neighbourhood. Examples are described of measures taken in plants to restrict emissions of evil-smelling chemicals into atmosphere and water, measures to restrict noise emission and examples of dealing with old environmental burdens. Examples of cooperation of company management with local public administration are also given.corresponding programs work.
