OBJECTIVES: The aim of the study was to determine the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis. METHODS: In patients with any stage of newly diagnosed syphilis swabs were performed from urethra, rectum, pharynx and cervix according to the gender and type of sexual intercourse. From these smears standard validated nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoeae infections were done. RESULTS: From 548 (488 men, 60 women) screened patients co-infection was detected in 15.9% of the cases. The majority of the co-infections (86.2%) were asymptomatic. The overall prevalence of chlamydial infection was 11.1% and 8.8% for gonococcal infections. In men who have sex with men (MSM) the prevalence of co-infections was significantly higher (20.0%) than in heterosexual men and women (4.2%) (p < 0.001). In MSM patients the presence of co-infection was significantly associated with HIV infection (p < 0.001). Among MSM 9.6% of the tests detected infection in anorectal site, while prevalence in urethral (2.8%) and pharyngeal (2.4%) localization was significantly lower. In heterosexual patients prevalence was less than 2.0% in all anatomic sites. CONCLUSIONS: The implementation of screening tests in case of sexually transmitted infections in patients with newly diagnosed syphilis is an important part in the management of this disease. These results suggest that screening of asymptomatic heterosexual patients leads to detection of minimum co-infections, but in MSM (especially HIV positive) should always be performed at least in anorectal site, where asymptomatic co-infections are common.

• MeSH
• Chlamydia trachomatis izolace a purifikace   MeSH
• chlamydiové infekce epidemiologie   MeSH
• gonorea epidemiologie   MeSH
• HIV infekce epidemiologie   MeSH
• homosexualita mužská statistika a číselné údaje   MeSH
• koinfekce MeSH
• lidé MeSH
• Neisseria gonorrhoeae izolace a purifikace   MeSH
• prevalence MeSH
• průřezové studie MeSH
• syfilis diagnóza   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

We describe the first case of chancroid seen in the Czech Republic, diagnosed in a 40-year-old heterosexual HIV-positive man. Despite genital localization of the ulcer, the transmission of Haemophilus ducreyi infection in our patient remains unclear, as he denied having sexual intercourse and he did not travel outside the Czech Republic for several months before the ulcer appeared. The correct diagnosis has been revealed by a multiplex nucleic acid amplification test. Physicians in countries in the eastern and central Europe region should be aware that chancroid can occur in their patients.

• MeSH
• azithromycin aplikace a dávkování   terapeutické užití   MeSH
• dospělí MeSH
• Haemophilus ducreyi účinky léků   izolace a purifikace   MeSH
• HIV séropozitivita komplikace   MeSH
• kombinace léků trimethoprim a sulfamethoxazol aplikace a dávkování   terapeutické užití   MeSH
• lidé MeSH
• lymfadenopatie etiologie   MeSH
• měkký vřed diagnóza   farmakoterapie   mikrobiologie   MeSH
• methicilin rezistentní Staphylococcus aureus účinky léků   izolace a purifikace   MeSH
• multiplexová polymerázová řetězová reakce MeSH
• stafylokokové infekce farmakoterapie   MeSH
• vřed etiologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH