Complex injuries to the posterior trunk can still pose a significant challenge to the reconstructive surgeon. Due to the lack of skin laxity, dependent anatomical location and the importance of the deeper structures, a systematic approach tailored to the individual defect should be considered for these types of reconstructions. In our case report, we present a reconstructive solution of a chronic defect of the back caused by resection of an ulceration. What was previously considered to be a relapse of a malignant melanoma turned out to be a chronic osteomyelitis of the spinous processes of the thoracic vertebrae. The defect after the resection of the ulceration and infected spinous processes of the thoracic vertebrae with exposed dorsal lamina was covered with pedicled myocutaneous flap. Reconstruction yielded well-vascularized tissue that provided sufficient volume and tissue quality. Even in the light of modern perforator flaps, local or locoregional muscle and myocutaneous flaps remain the first choice for the treatment of deep back defects. Considering all the factors in the given case, plastic surgeons are able to tailor the reconstructive technique to every individual case to match the desired reconstruction goal.
- MeSH
- chirurgické laloky * chirurgie MeSH
- dermatochirurgické výkony metody MeSH
- hrudní obratle chirurgie patologie MeSH
- lidé MeSH
- maligní melanom kůže komplikace MeSH
- osteomyelitida * chirurgie MeSH
- pooperační péče metody MeSH
- senioři MeSH
- stafylokokové infekce komplikace MeSH
- vřed chirurgie komplikace patologie MeSH
- záda chirurgie patologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- kazuistiky MeSH
Příspěvek se zaměřuje na rány a ulcerace povrchového charakteru na genitálu u mužů, které často vznikají v důsledku dekompenzace zdravotního stavu pacienta v podmínkách intenzivní péče. Předkládá možné ošetření a léčbu při použití způsobu vlhké terapie vybranými terapeutickými materiály. V příspěvku nejsou vyjmenovány všechny dostupné přípravky. Autorka si je vědoma, že lokální léčba může být prováděna rovněž pomocí magistraliter specialistou z oboru dermatologie. Účelem příspěvku je předložit postup ošetření a léčby, který může být prováděn v běžných podmínkách nemocniční, ambulantní nebo domácí péče v závislosti na typu poškození a fázi vývoje hojení.
This paper focuses on superficial wounds and ulcerations of male genitalia, which often arise as a result of decompesation of the patien'ts health state in the conditions of intensive care. It presents possible care and treatment using moist wound healing method with selected therapeutic dressings. The artical can not include all available dressings. The author is aware of the fact, that local treatment can also be carried out using magistraliter preparation by a specialist in the field of a dermatology. The aim of the paper is to present care and treatment procedures that can be carried out in common conditions in hospital, outpatient as well as at home care depending on the type of damage and the stage of healing process.
PURPOSE: To evaluate the safety and efficacy of using corneal stromal lenticules (CSLs) obtained during refractive surgery Refractive Lenticule Extraction (ReLEx) with the Small Incision Lenticule Extraction (SMILE) procedure for the treatment of corneal ulcers. METHODS: This retrospective study included 12 eyes of 12 patients, 7 men and 5 women with varying degrees of corneal ulcer. The mean age was 64 ± 18 (range 34 to 95 years). The monitoring included corrected distance visual acuity (CDVA), slit-lamp biomicroscopy examination, a Seidel test, stability of the graft and anterior segment optical coherence tomography (AS-OCT) inspection. Patients were closely monitored for possible postoperative complications for at least 6 months. RESULTS: In 7/12 (58%) eyes, the corneal ulcer was successfully sealed with CSL and amniotic membrane (AM) without the need for any additional surgical intervention. In 3 eyes, penetrating keratoplasty (PK) was needed in addition to CSL transplantation and in 2 eyes the scleral patch was used to fully seal after CSL transplantation. During the follow-up period no signs of rejection or infection were detected in any patient. CONCLUSION: The use of CSLs from ReLEx SMILE may be considered as an alternative method for the treatment of corneal ulcers before a more extensive and definitive solution - PK - is used. Our preliminary findings suggest that properly performed CSL transplantation using cryopreserved lenticules is a safe and effective method to temporarily cover the corneal partial-thickness defect or even perforation.
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stroma rohovky chirurgie MeSH
- transplantace rohovky * metody MeSH
- vřed rohovky * chirurgie MeSH
- vřed chirurgie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Yaws is an endemic disease caused by Treponema pallidum subsp. pertenue (TPE) that primarily affects children in rural regions of the tropics. The endemic character of yaws infections and the expected exclusive reservoir of TPE in humans opened a new opportunity to start a yaws eradication campaign. We have developed a multi-locus sequence typing (MLST) scheme for TPE isolates combining the previously published (TP0548, TP0488) and new (TP0858) chromosomal loci, and we compared this typing scheme to the two previously published MLST schemes. We applied this scheme to TPE-containing clinical isolates obtained during a mass drug administration study performed in the Namatanai District of Papua New Guinea between June 2018 and December 2019. Of 1081 samples collected, 302 (28.5%) tested positive for TPE DNA, from which 255 (84.4%) were fully typed. The TPE PCR-positivity in swab samples was higher in younger patients, patients with single ulcers, first ulcer episodes, and with ulcer duration less than six months. Non-treponemal serological test positivity correlated better with PCR positivity compared to treponema-specific serological tests. The MLST revealed a low level of genetic diversity among infecting TPE isolates, represented by just three distinct genotypes (JE11, SE22, and TE13). Two previously used typing schemes revealed similar typing resolutions. Two new alleles (one in TP0858 and one in TP0136) were shown to arise by intragenomic recombination/deletion events. Compared to samples genotyped as JE11, the minor genotypes (TE13 and SE22) were more frequently detected in samples from patients with two or more ulcers and patients with higher values of specific TP serological tests. Moreover, the A2058G mutation in the 23S rRNA genes of three JE11 isolates was found, resulting in azithromycin resistance.
- MeSH
- dítě MeSH
- frambézie * epidemiologie MeSH
- genotyp MeSH
- lidé MeSH
- multilokusová sekvenční typizace MeSH
- mutace MeSH
- Treponema pallidum * genetika MeSH
- Treponema genetika MeSH
- vřed MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Papua Nová Guinea MeSH
Příspěvek se zaměřuje na rány a ulcerace povrchového charakteru na genitálu u mužů, které často vznikají v důsledku dekompenzace zdravotního stavu pacienta v podmínkách intenzivní péče. Předkládá možné ošetření a léčbu při použití způsobu vlhké terapie vybranými terapeutickými materiály. V příspěvku nejsou vyjmenovány všechny dostupné přípravky. Autorka si je vědoma, že lokální léčba může být prováděna rovněž pomocí magistraliter specialistou z oboru dermatologie. Účelem příspěvku je předložit postup ošetření a léčby, který může být prováděn v běžných podmínkách nemocniční, ambulantní nebo domácí péče v závislosti na typu poškození a fázi vývoje hojení.
This paper focuses on superficial wounds and ulcerations of male genitalia, which often arise as a result of decompesation of the patien'ts health state in the conditions of intensive care. It presents possible care and treatment using moist wound healing method with selected therapeutic dressings. The artical can not include all available dressings. The author is aware of the fact, that local treatment can also be carried out using magistraliter preparation by a specialist in the field of a dermatology. The aim of the paper is to present care and treatment procedures that can be carried out in common conditions in hospital, outpatient as well as at home care depending on the type of damage and the stage of healing process.
Akútne genitálne ulcerácie sú zriedkavo sa vyskytujúce kožné prejavy so širokou diferenciálnou diagnostikou. Etiopatogenéza ochorenia nie je úplne objasnená, hoci existujú určité príčinné súvislosti s daným ochorením. V texte je popísaný konkrétny prípad pacientky s genitálnymi vredmi, asociovaný s akútne prebiehajúcou Lymskou boreliózou.
Acute genital ulcers are rare skin manifestations with a wide differential diagnosis. The etiopathogenesis of the disease is not completely understood, although there are certain causal relationships with the condition. The text describes a specific case of a female patient with genital ulcers associated with acute Lyme disease.
- Klíčová slova
- ulcus vulvae acutum,
- MeSH
- dospělí MeSH
- doxycyklin aplikace a dávkování terapeutické užití MeSH
- erythema chronicum migrans MeSH
- lidé MeSH
- lymeská nemoc * diagnóza farmakoterapie komplikace MeSH
- makrolidy aplikace a dávkování terapeutické užití MeSH
- vřed MeSH
- vulva patologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- COVID-19 * komplikace MeSH
- jazyk MeSH
- lidé MeSH
- SARS-CoV-2 MeSH
- vřed MeSH
- vředy v ústech * etiologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- dopisy MeSH
- komentáře MeSH
PURPOSE OF THE STUDY Population aging is connected with an increased incidence of chronic diseases. A common related problem is chronic skin ulcers, which, while not life-threatening, can significantly decrease the quality of the patient's life. The present study aims to evaluate new materials and methods to improve and accelerate the treatment of leg ulcers. MATERIAL AND METHODS Twenty-five patients with chronic ulcers treated using autologous growth factors applied on a nanofiber carrier were included in the cohort. The control group consisted of 15 patients treated using standard moist wound therapy. The surface area of the ulcer was measured on the 0th, 14th, 28th, 56th, 84th, 112th, 140th, 140th, and 168th day of treatment. Ulcer depth was measured on the 0th, 5th, 28th, 84th, and 168th day of treatment. Results were statistically processed and evaluated. RESULTS During the study, the defect area decreased in both the control and experimental group. Statistically significantly better results were observed in the experimental group relative to the progress of ulcer depth. The experimental group also had more healed ulcers. DISCUSSION Moistness is necessary for chronic wounds to heal; it is needed to ensure optimal cell growth, angiogenesis, and fibrinolysis. Wounds can be treated using non-active dressings with high absorption qualities; however, these do not guarantee optimal conditions for healing, or wounds can be treated with an interactive dressing that interacts with the wound surface. The third option for treatment is the use of bioactive materials that adhere to the wound and participate directly in the individual stages of healing. CONCLUSIONS The study found that autologous growth factors had statistically significant effects on the treatment of chronic ulcers. The authors believe that this method can accelerate the healing of primary post-injury or secondary postoperative wounds of lower leg soft tissues. Key words: trophic ulcer, autologous growth factors, microangiopathy, polyneuropathy, diabetes mellitus.
- MeSH
- lidé MeSH
- nanovlákna * terapeutické užití MeSH
- pilotní projekty MeSH
- plazma bohatá na destičky * MeSH
- vřed MeSH
- vředy dolních končetin * terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Gastropathy is one of the most common diseases of the human gastrointestinal tract. Apart from its consequences in the stomach, it is also manifested in other parts of the digestive tract, particularly in the duodenum. The aim of this pilot study was to verify on animal model the empirically observed alleviation of gastropathy symptoms in patients who underwent a drinking treatment of Vincentka natural mineral water during their spa treatment. Sixteen male Wistar rats were included in the study. The animals were randomly divided into two groups: experimental group (E; n=8) and control group (C; n=8). The experimental protocol consisted of three phases: (1) handling phase (7 days); (2) mineral water (E)/tap water (C) administration (7 days); (3) acute gastritis induction (1 day). Twenty-four hours after the induction of acute gastritis, the animals were sacrificed. The collected tissues (stomach and duodenum) and blood were examined by standard histological microscopy, and by immunohistochemical and biochemical methods. Histopathological analysis revealed significantly reduced damage to the gastric mucosa in the experimental group. Significantly different values of blood plasma antioxidant capacity, oxidative stress parameters and blood plasma biochemical parameters were also found. Based on these results, we conclude that the mineral water Vincentka has a positive impact on development and symptoms of acute gastric ulcers.
