PURPOSE OF THE STUDY To evaluate the therapeutic effects of small incision open reduction and internal fixation and arthroscopic high strength non-absorbable suture on tibial insertion avulsion fracture of the anterior cruciate ligament (ACL). MATERIAL AND METHODS In this prospectively study, 72 patients with ACL tibial insertion avulsion fracture treated from December 2017 to June 2020 were enrolled and divided into group A (treated with small incision open reduction and cannulated screw internal fixation) and group B (treated with arthroscopic high strength non-absorbable suture) using a random number table (n=36). Their general data, surgical indices and incidence of postoperative adverse reactions were compared. Knee function indices were compared before and after treatment, and evaluated by random walk model. RESULTS No significant differences were found in the general data, intraoperative blood loss, preoperative Lysholm score, International Knee Documentation Committee (IKDC) score, Tegner score, knee range of motion and difference of bilateral tibial forward displacement distance, and total incidence rate of postoperative adverse reactions between the two groups (P>0.05). Group B had significantly longer operation time, and significantly shorter hospital stay, time of first ambulation after operation and bone healing time than group A (P<0.05). Both groups had improved Lysholm score, IKDC score, Tegner score and knee range of motion after treatment, especially in group B (P<0.05). The difference of bilateral tibial forward displacement distance significantly reduced in both groups after treatment, particularly in group B (P<0.05). The random walk model revealed that group B had better improvement of knee function than group A. CONCLUSIONS Arthroscopic high strength non-absorbable suture in the treatment of ACL tibial insertion avulsion fracture can dramatically improve the knee function indices of patients, with rapid recovery and high safety, so it has a broad prospect of clinical application. Key words: small incision open reduction and internal fixation, arthroscopic high strength non-absorbable suture, tibial insertion avulsion fracture, anterior cruciate ligament, random walk model.

• MeSH
• Arthroscopy adverse effects   methods   MeSH
• Fractures, Avulsion * surgery   MeSH
• Tibial Fractures * surgery   MeSH
• Knee Joint surgery   MeSH
• Humans MeSH
• Anterior Cruciate Ligament surgery   MeSH
• Anterior Cruciate Ligament Injuries * surgery   MeSH
• Suture Techniques MeSH
• Sutures MeSH
• Treatment Outcome MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH

This study was aimed to determine whether the leptin receptor Gln223Arg polymorphism has an effect on plasma leptin levels and left ventricular hypertrophy in hypertension. The genotypes and allelic frequencies of the leptin receptor Gln223Arg were examined using the polymerase chain reaction and restriction fragment length polymorphism in 190 hypertensive patients and 88 healthy controls. Logarithmic (log) transformation of the plasma leptin level was carried out before performing comparison and regression analysis. The values of log(plasma leptin levels) in the hypertensive patients were higher than those of controls and they were higher in hypertensive patients with left ventricular hypertrophy than those without it (P < 0.05). The genotype (AA, AG, and GG) distribution of Gln223Arg polymorphism was 6.8, 33.8, and 59.4% in hypertensive patients with left ventricular hypertrophy, 4.3, 27.6, and 68.1% in patients without left ventricular hypertrophy, and 2.3, 26.1, and 71.6% in the controls, respectively. A significant difference was found among these three groups (P < 0.05). The frequency of allele A was higher in patients with left ventricular hypertrophy than in patients without it (23.6 vs. 18.1%; P < 0.05). Log(plasma leptin levels) and left ventricular mass index were higher in patients with the AA genotype than those with the AG or GG genotype in hypertensive patients (P < 0.05). In multivariate regression analysis, the AA genotype as an independent predictor had statistically significant effects on the left ventricular mass index. Our results suggest that the Gln223Arg polymorphism of the leptin receptor is significantly associated with plasma leptin levels and left ventricular hypertrophy in hypertension.

• MeSH
• Adult MeSH
• Echocardiography MeSH
• Genotype MeSH
• Hypertrophy, Left Ventricular genetics   MeSH
• Receptors, Leptin genetics   MeSH
• Middle Aged MeSH
• Humans MeSH
• Polymorphism, Genetic genetics   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

Na základe kritiky pôvodnej verzie Zjednotenej hodnotiacej škály pre Parkinsonovu chorobu – Unified Parkinson's Disease Rating Scale (UPDRS) boli vytvorené odporúčania pre tvorbu revidovanej verzie tejto škály. Následne bola zostavená Movement Disorder Society (MDS) – sponzorovaná revidovaná škála s označením Movement Disorder Society – Unified Parkinson's Disease Rating Scale (MDS‑UPDRS). Po jej úspešnom klinimetrickom testovaní a validizácii bol zahájený program validizácie neanglických prekladov MDS‑UPDRS. Cieľom tejto práce bolo potvrdiť faktorovú štruktúru a validizovať slovenskú verziu MDS‑UPDRS. Pomocou slovenskej verzie MDS‑UPDRS bolo vyšetrených 354 pacientov s Parkinsonovou chorobou vo všetkých štádiách ochorenia podľa Hoehna a Yahrovej. Priemerný vek pacientov bol 68 ? 9,5 rokov a priemerná dĺžka ochorenia 6,7 ? 5,1 rokov. Pomocou konfirmačnej faktorovej analýzy boli slovenské údaje porovnané s pôvodnou anglickou verziou, pričom podmienkou pre uznanie slovenského prekladu ako oficiálnej verzie MDS‑UPDRS bol komparačný index zhody (CFI) ≥ 0,90 pre všetky štyri časti škály. Následne bola realizovaná exploračná faktorová analýza, ktorej cieľom bolo určiť nezávisle faktorovú štruktúru slovenskej verzie MDS‑UPDRS. Komparačná faktorová analýza všetkých štyroch častí slovenskej a anglickej verzie MDS‑UPDRS potvrdila zhodu faktorovej štruktúry (CFI > 0,91). Pri exploračnej faktorovej analýze boli identifikované izolované odlišnosti faktorovej štruktúry slovenskej a anglickej verzie MDS‑UPDRS. Slovenská verzia MDS‑UPDRS bola uznaná ako šiesty oficiálny neanglický preklad MDS‑UPDRS a preklad škály spolu s on‑line výučbovým kurzom v slovenčine sú dostupné na webovej stránke Movement Disorder Society (http://www.movementdisorders.org/publications/rating_scales/). V tejto práci tiež sumarizujeme základné zmeny a výhody MDS‑UPDRS oproti pôvodnej verzii UPDRS.

Following its critique, recommendations for revision of the original version of the Unified Parkinson's Disease Rating Scale (UPDRS) were published. Subsequently, the Movement Disorder Society (MDS) – sponsored revision entitled Movement Disorder Society – Unified Parkinson's Disease Rating Scale (MDS-UPDRS) was presented. After its successful clinimetric testing, a programme for translation and validation of non-English versions of the MDS-UPDRS was initiated. The aim of this study was to validate and confirm the factor structure of the Slovak translation of the MDS-UPDRS. We examined 354 patients with Parkinson's disease in all Hoehn and Yahr stages with the Slovak version of the MDS-UPDRS. The mean age of our sample was 68 ? 9.5 years and the mean disease duration was 6.7 ? 5.1 years. Slovak data were compared using confirmatory factor analysis with the original English language data. The pre-specified criterion for approving the Slovak translation as an official version of the MDS-UPDRS was the comparative fit index (CFI) ≥ 0.90 for all four parts of the Slovak MDS-UPDRS. An exploratory factor analysis was performed to explore the underlying factor structure without the constraints of a pre-specified factor structure. When compared to the English-language factor structure, the CFI for all four parts of the Slovak MDS-UPDRS was 0.91 or greater. Isolated differences in factor structure of the Slovak MDS-UPDRS compared to the English version were identified by exploratory factor analysis. The Slovak version of the MDS-UPDRS was accredited as the sixth official non-English translation of the MDS-UPDRS and can be downloaded from the Movement Disorder Society's website (http://www.movementdisorders.org/publications/rating_scales/), along with training materials using the Slovak translation. In this paper, we also present the major changes and advantages of the Slovak MDS-UPDRS compared with the original UPDRS.

• Keywords
• hodnotící škály, faktorová analýza,
• MeSH
• Factor Analysis, Statistical MeSH
• Middle Aged MeSH
• Humans MeSH
• Neurologic Examination * standards   MeSH
• Parkinson Disease * diagnosis   complications   MeSH
• Movement Disorders MeSH
• Reproducibility of Results MeSH
• Aged MeSH
• Societies, Medical standards   MeSH
• Severity of Illness Index * MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH
• Validation Study MeSH
• Geographicals
• Slovakia MeSH