BACKGROUND: Over 16 000 children under the age of 15 died worldwide in 2017 because of liver disease. Pediatric liver transplantation (PLT) is currently the standard of care for these patients. The aim of this study is to describe global PLT activity and identify variations between regions. METHODS: A survey was conducted from May 2018 to August 2019 to determine the current state of PLT. Transplant centers were categorized into quintile categories according to the year they performed their first PLT. Countries were classified according to gross national income per capita. RESULTS: One hundred eight programs from 38 countries were included (68% response rate). 10 619 PLTs were performed within the last 5 y. High-income countries performed 4992 (46.4%) PLT, followed by upper-middle- (4704 [44·3%]) and lower-middle (993 [9·4%])-income countries. The most frequently used type of grafts worldwide are living donor grafts. A higher proportion of lower-middle-income countries (68·7%) performed ≥25 living donor liver transplants over the last 5 y compared to high-income countries (36%; P = 0.019). A greater proportion of programs from high-income countries have performed ≥25 whole liver transplants (52.4% versus 6.2%; P = 0.001) and ≥25 split/reduced liver transplants (53.2% versus 6.2%; P < 0.001) compared to lower-middle-income countries. CONCLUSIONS: This study represents, to our knowledge, the most geographically comprehensive report on PLT activity and a first step toward global collaboration and data sharing for the greater good of children with liver disease; it is imperative that these centers share the lead in PLT.

• MeSH
• dítě MeSH
• lidé MeSH
• nemoci jater * MeSH
• sčítání lidu MeSH
• smrt MeSH
• transplantace jater * škodlivé účinky   MeSH
• žijící dárci MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

The purpose of this registry study was to provide an overview of trends and results of liver transplantation (LT) in Europe from 1968 to 2016. These data on LT were collected prospectively from 169 centers from 32 countries, in the European Liver Transplant Registry (ELTR) beginning in 1968. This overview provides epidemiological data, as well as information on evolution of techniques, and outcomes in LT in Europe over more than five decades; something that cannot be obtained from only a single center experience.

• MeSH
• čas zasáhnout při rozvinutí nemoci MeSH
• dárci tkání MeSH
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• nádory jater chirurgie   MeSH
• nemoci jater chirurgie   MeSH
• přežívání štěpu MeSH
• prospektivní studie MeSH
• průzkumy a dotazníky MeSH
• registrace * MeSH
• reoperace MeSH
• senioři MeSH
• transplantace jater statistika a číselné údaje   MeSH
• zeměpis MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Evropa MeSH

The aim of this study was to collect data from patients who underwent liver transplantation (LT) for adenomatosis; to analyze the symptoms, the characteristics of the disease, and the recipient outcomes; and to better define the role of LT in this rare indication. This retrospective multicenter study, based on data from the European Liver Transplant Registry, encompassed patients who underwent LT for adenomatosis between January 1, 1986, and July 15, 2013, in Europe. Patients with glycogen storage disease (GSD) type IA were not excluded. This study included 49 patients. Sixteen patients had GSD, and 7 had liver vascular abnormalities. The main indications for transplantation were either a suspicion of hepatocellular carcinoma (HCC; 15 patients) or a histologically proven HCC (16 patients), but only 17 had actual malignant transformation (MT) of adenomas. GSD status was similar for the 2 groups, except for age and the presence of HCC on explants (P = 0.030). Three patients with HCC on explant developed recurrence after transplantation. We obtained and studied the pathomolecular characteristics for 23 patients. In conclusion, LT should remain an extremely rare treatment for adenomatosis. Indications for transplantation primarily concern the MT of adenomas. The decision should rely on morphological data and histological evidence of MT. Additional indications should be discussed on a case-by-case basis. In this report, we propose a simplified approach to this decision-making process.

• MeSH
• dospělí MeSH
• glykogenóza typu I chirurgie   MeSH
• hepatocelulární adenom patologie   chirurgie   MeSH
• hepatocelulární karcinom patologie   chirurgie   MeSH
• klinické rozhodování metody   MeSH
• kohortové studie MeSH
• lidé MeSH
• nádory jater patologie   chirurgie   MeSH
• registrace statistika a číselné údaje   MeSH
• retrospektivní studie MeSH
• transplantace jater statistika a číselné údaje   MeSH
• výsledek terapie MeSH
• vzácné nemoci chirurgie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• Geografické názvy
• Evropa epidemiologie   MeSH

• MeSH
• analýza přežití MeSH
• hepatocelulární karcinom * chirurgie   krev   mortalita   patologie   MeSH
• hodnocení rizik MeSH
• lidé MeSH
• nádorové biomarkery analýza   MeSH
• neoadjuvantní terapie metody   mortalita   MeSH
• transplantace jater mortalita   škodlivé účinky   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé MeSH

• MeSH
• dítě MeSH
• dospělí MeSH
• longitudinální studie MeSH
• transplantace jater MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• Publikační typ
• sborníky MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• transplantologie
• hepatologie
• pediatrie