JavaScript NENÍ povolen !

Postpartum depression affects 10-15 % women after childbirth. There is no currently generally accepted theory about the causes and mechanisms of postpartum mental disorders. The principal hypothesis concerns the association with sudden changes in the production of hormones affecting the nervous system of the mother and, on the other hand, with the ability of receptor systems to adapt to these changes. We observed changes in steroidogenesis in the period around spontaneous delivery. We collected three samples of maternal blood. The first sampling was 4 weeks prior to term; the second sampling was after the onset of uterine contractions (the beginning of spontaneous labour); the third sampling was during the third stage of labour (immediately after childbirth). Additionally, we collected mixed umbilical cord blood. The almost complete steroid metabolome was analyzed by gas chromatography-mass spectrometry followed by RIA for some steroids. Mental changes in women in the peripartum period were observed using the Hamilton Depression Rating Scale. The local Ethics Committee approved the study. We found already the changes in androgens levels correlating with postpartum mood disorders four weeks prior to childbirth. The strongest correlations between steroid and postpartum mood change were found in venous blood samples collected from mothers after childbirth and from umbilical cord blood. The main role played testosterone, possibly of maternal origin, and estrogens originating from the fetal compartment. These results suggest that changes in both maternal and fetal steroidogenesis are involved in the development of mental changes in the postpartum period. Descriptions of changes in steroidogenesis in relation to postpartum depression could help clarify the causes of this disease, and changes in some steroid hormones are a promising marker of mental changes in the postpartum period.

MeSH
biologické markery krev MeSH
časové faktory MeSH
dospělí MeSH
lidé MeSH
metabolomika metody MeSH
plynová chromatografie s hmotnostně spektrometrickou detekcí MeSH
pohlavní steroidní hormony krev MeSH
poporodní deprese krev diagnóza MeSH
radioimunoanalýza MeSH
stupeň závažnosti nemoci MeSH
těhotenství MeSH
Check Tag
dospělí MeSH
lidé MeSH
těhotenství MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

Článek

Netypická bolest při ruptuře děložní
[Atypical pain in the uterine rupture]

Česká gynekologie. 2012 ; 77 (4) : 358-360.

ISSN 1210-7832
Medvik
Zdroj

Cíl studie: Upozornit na vzácnou komplikaci těhotenství. Typ studie: Kazuistika. Název a sídlo pracoviště: Gynekologicko-porodnická klinika 1. LF UK a VFN Praha. Předmět a metoda studie: Uvedený případ popisuje symptomy náhlé příhody břišní imitující apendicitidu, které překrývaly probíhající rupturu děložní. Závěr: Ruptura děložní je vzácná komplikace těhotenství. V současné době, se zvyšujícím se počtem císařských řezů a prenatálních operativních výkonů na děloze, je nutno více pomýšlet na popisovanou komplikaci.

Objective: To give attention to the rare complication of pregnancy. Design: Case report. Settings: Dept. of Obstetric and Gynecology, 1st Faculty of Medicine, Charles University and General Faculty Hospital Prague. Methods: Description of acute abdominal pain which immitated the appendicitis in case of the uterine rupture. Conclusion: The uterine rupture is the rare and very dangerous complication of pregnancy. In the time of increasing number of the cesarean section and the operation on the uterine wall, we must thing on the uterine rupture.