- MeSH
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics therapy MeSH
- Genetic Therapy methods trends MeSH
- Genome, Human genetics MeSH
- HIV Infections genetics therapy MeSH
- Disease Vectors MeSH
- Mosquito Vectors genetics MeSH
- Liposomes MeSH
- Drug Carriers MeSH
- RNA Interference physiology immunology MeSH
- Clustered Regularly Interspaced Short Palindromic Repeats * genetics MeSH
JC and BK polyomaviruses (JCV and BKV) infect humans and can cause severe illnesses in immunocompromised patients. Merkel cell polyomavirus (MCPyV) can be found in skin carcinomas. In this study, we assessed the occurrence of serum antibodies against MCPyV, BKV, and JCV polyomaviruses in a healthy population of the Czech Republic. Serum samples from 991 healthy individuals (age range: 6-64 years) were examined by enzyme-linked immunoassay (ELISA) using virus-like particles (VLPs) based on the major VP1 capsid proteins of these viruses. Overall, serum antibodies against MCPyV, JCV, and BKV were found in 63%, 57%, and 69%, respectively, of this population. For all three viruses, these rates were associated with age; the occurrence of antibodies against MCPyV and JCV was highest for those older than 59 years, while the occurrence of antibodies against BKV was highest in those aged 10-19 years and 20-29 years. This is the first large study to determine the seroprevalence rates for BKV, JCV, and MCPyV polyomaviruses in the general Czech Republic population.
- MeSH
- Cell Line MeSH
- Child MeSH
- Adult MeSH
- Tumor Virus Infections blood epidemiology virology MeSH
- Infant MeSH
- Middle Aged MeSH
- Humans MeSH
- Merkel cell polyomavirus immunology MeSH
- Adolescent MeSH
- Young Adult MeSH
- Mice, Inbred ICR MeSH
- Polyomavirus Infections blood epidemiology virology MeSH
- Child, Preschool MeSH
- Antibodies, Viral blood MeSH
- Seroepidemiologic Studies MeSH
- Case-Control Studies MeSH
- Age Distribution MeSH
- BK Virus immunology MeSH
- JC Virus immunology MeSH
- Animals MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
Novel biomaterials based on hydrophilic polycaprolactone and polyurethane (Tecophilic®) nanofibers with an encapsulated 5,10,5,20-tetraphenylporphyrin photosensitizer were prepared by electrospinning. The doped nanofiber textiles efficiently photo-generate O(2)((1)Δ(g)), which oxidize external chemical and biological substrates/targets. Strong photo-virucidal effects toward non-enveloped polyomaviruses and enveloped baculoviruses were observed on the surface of these textiles. The photo-virucidal effect was confirmed by a decrease in virus infectivity. In contrast, no virucidal effect was detected in the absence of light and/or the encapsulated photosensitizer.
- MeSH
- Anthracenes chemistry MeSH
- Antiviral Agents pharmacology MeSH
- Baculoviridae drug effects MeSH
- Photosensitizing Agents pharmacology MeSH
- Virus Inactivation drug effects MeSH
- Capsid chemistry MeSH
- Mice MeSH
- Nanofibers chemistry ultrastructure MeSH
- Oxidation-Reduction MeSH
- Polyesters chemistry MeSH
- Polyomavirus drug effects MeSH
- Polyurethanes chemistry MeSH
- Porphyrins pharmacology MeSH
- Recombination, Genetic genetics MeSH
- Singlet Oxygen metabolism MeSH
- Textiles * MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- MeSH
- Killer Cells, Natural immunology MeSH
- Cytotoxicity, Immunologic MeSH
- T-Lymphocytes, Cytotoxic immunology MeSH
- Sarcoma, Experimental immunology blood MeSH
- Research Support as Topic MeSH
- Rats, Inbred Strains MeSH
- Neoplasm Invasiveness immunology ultrastructure MeSH
- Disease Models, Animal MeSH
- Tumor Cells, Cultured MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
