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Autor: Pimentel, Jose

6 záznamů v Medvik Filtry

Článek

Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue

Sanders, Maurits W
Autor Sanders, Maurits W ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Van der Wolf, Iskander
Autor Van der Wolf, Iskander ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Jansen, Floor E
Autor Jansen, Floor E ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Aronica, Eleonora
Autor Aronica, Eleonora ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Helmstaedter, Christoph
Autor Helmstaedter, Christoph ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Racz, Attila
Autor Racz, Attila ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Surges, Rainer
Autor Surges, Rainer ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Grote, Alexander
Autor Grote, Alexander ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Becker, Albert J
Autor Becker, Albert J ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Rheims, Sylvain
Autor Rheims, Sylvain ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany

Neurology. 2024 ; 102 (4) : e208007. [pub] 20240130

ISSN 1526-632X
Medvik
Zdroj

BACKGROUND AND OBJECTIVE: Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared with lesional patients. In this study, we aimed to characterize a large group of patients with focal epilepsy who underwent epilepsy surgery despite a normal MRI and had no lesion on histopathology. Determinants of their postoperative seizure outcomes were further studied. METHODS: We designed an observational multicenter cohort study of MRI-negative and histopathology-negative patients who were derived from the European Epilepsy Brain Bank and underwent epilepsy surgery between 2000 and 2012 in 34 epilepsy surgery centers within Europe. We collected data on clinical characteristics, presurgical assessment, including genetic testing, surgery characteristics, postoperative outcome, and treatment regimen. RESULTS: Of the 217 included patients, 40% were seizure-free (Engel I) 2 years after surgery and one-third of patients remained seizure-free after 5 years. Temporal lobe surgery (adjusted odds ratio [AOR]: 2.62; 95% CI 1.19-5.76), shorter epilepsy duration (AOR for duration: 0.94; 95% CI 0.89-0.99), and completely normal histopathologic findings-versus nonspecific reactive gliosis-(AOR: 4.69; 95% CI 1.79-11.27) were significantly associated with favorable seizure outcome at 2 years after surgery. Of patients who underwent invasive monitoring, only 35% reached seizure freedom at 2 years. Patients with parietal lobe resections had lowest seizure freedom rates (12.5%). Among temporal lobe surgery patients, there was a trend toward favorable outcome if hippocampectomy was part of the resection strategy (OR: 2.94; 95% CI 0.98-8.80). Genetic testing was only sporadically performed. DISCUSSION: This study shows that seizure freedom can be reached in 40% of nonlesional patients with both normal MRI and histopathology findings. In particular, nonlesional temporal lobe epilepsy should be regarded as a relatively favorable group, with almost half of patients achieving seizure freedom at 2 years after surgery-even more if the hippocampus is resected-compared with only 1 in 5 nonlesional patients who underwent extratemporal surgery. Patients with an electroclinically identified focus, who are nonlesional, will be a promising group for advanced molecular-genetic analysis of brain tissue specimens to identify new brain somatic epilepsy genes or epilepsy-associated molecular pathways.

MeSH
elektroencefalografie MeSH
epilepsie parciální * diagnostické zobrazování chirurgie MeSH
epilepsie temporálního laloku * chirurgie MeSH
epilepsie * diagnostické zobrazování chirurgie MeSH
kohortové studie MeSH
lidé MeSH
magnetická rezonanční tomografie MeSH
retrospektivní studie MeSH
výsledek terapie MeSH
záchvaty MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH
multicentrická studie MeSH
pozorovací studie MeSH

Článek

Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma

Journal of clinical oncology. 2021 ; 39 (7) : 807-821. [pub] 20210127

J. clin. Oncol.
ISSN 1527-7755
Medvik
Zdroj

PURPOSE: We sought to investigate clinical outcomes of relapsed medulloblastoma and to compare molecular features between patient-matched diagnostic and relapsed tumors. METHODS: Children and infants enrolled on either SJMB03 (NCT00085202) or SJYC07 (NCT00602667) trials who experienced medulloblastoma relapse were analyzed for clinical outcomes, including anatomic and temporal patterns of relapse and postrelapse survival. A largely independent, paired molecular cohort was analyzed by DNA methylation array and next-generation sequencing. RESULTS: A total of 72 of 329 (22%) SJMB03 and 52 of 79 (66%) SJYC07 patients experienced relapse with significant representation of Group 3 and wingless tumors. Although most patients exhibited some distal disease (79%), 38% of patients with sonic hedgehog tumors experienced isolated local relapse. Time to relapse and postrelapse survival varied by molecular subgroup with longer latencies for patients with Group 4 tumors. Postrelapse radiation therapy among previously nonirradiated SJYC07 patients was associated with long-term survival. Reirradiation was only temporizing for SJMB03 patients. Among 127 patients with patient-matched tumor pairs, 9 (7%) experienced subsequent nonmedulloblastoma CNS malignancies. Subgroup (96%) and subtype (80%) stabilities were largely maintained among the remainder. Rare subgroup divergence was observed from Group 4 to Group 3 tumors, which is coincident with genetic alterations involving MYC, MYCN, and FBXW7. Subgroup-specific patterns of alteration were identified for driver genes and chromosome arms. CONCLUSION: Clinical behavior of relapsed medulloblastoma must be contextualized in terms of up-front therapies and molecular classifications. Group 4 tumors exhibit slower biological progression. Utility of radiation at relapse is dependent on patient age and prior treatments. Degree and patterns of molecular conservation at relapse vary by subgroup. Relapse tissue enables verification of molecular targets and identification of occult secondary malignancies.

MeSH
časové faktory MeSH
dítě MeSH
epigenom MeSH
epigenomika MeSH
klinické zkoušky jako téma MeSH
kojenec MeSH
lidé MeSH
lokální recidiva nádoru * MeSH
meduloblastom genetika mortalita sekundární terapie MeSH
metylace DNA * MeSH
nádorové biomarkery genetika MeSH
nádory mozečku genetika mortalita patologie terapie MeSH
opakovaná terapie MeSH
předškolní dítě MeSH
progrese nemoci MeSH
výsledek terapie MeSH
vysoce účinné nukleotidové sekvenování MeSH
Check Tag
dítě MeSH
kojenec MeSH
lidé MeSH
mužské pohlaví MeSH
předškolní dítě MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
multicentrická studie MeSH
práce podpořená grantem MeSH
srovnávací studie MeSH

Článek

Epilepsy surgery in drug resistant temporal lobe epilepsy associated with neuronal antibodies

Epilepsy research. 2017 ; 129 (-) : 101-105. [pub] 20161215

Epilepsy Res
ISSN 1872-6844
Medvik
Zdroj

We assessed the outcome of patients with drug resistant epilepsy and neuronal antibodies who underwent epilepsy surgery. Retrospective study, information collected with a questionnaire sent to epilepsy surgery centers. Thirteen patients identified, with antibodies to GAD (8), Ma2 (2), Hu (1), LGI1 (1) or CASPR2 (1). Mean age at seizure onset: 23 years. Five patients had an encephalitic phase. Three had testicular tumors and five had autoimmune diseases. All had drug resistant temporal lobe epilepsy (median: 20 seizures/month). MRI showed unilateral temporal lobe abnormalities (mainly hippocampal sclerosis) in 9 patients, bilateral abnormalities in 3, and was normal in 1. Surgical procedures included anteromesial temporal lobectomy (10 patients), selective amygdalohippocampectomy (1), temporal pole resection (1) and radiofrequency ablation of mesial structures (1). Perivascular lymphocytic infiltrates were seen in 7/12 patients. One year outcome available in all patients, at 3 years in 9. At last visit 5/13 patients (38.5%) (with Ma2, Hu, LGI1, and 2 GAD antibodies) were in Engel's classes I or II. Epilepsy surgery may be an option for patients with drug resistant seizures associated with neuronal antibodies. Outcome seems to be worse than that expected in other etiologies, even in the presence of unilateral HS. Intracranial EEG may be required in some patients.

MeSH
autoprotilátky krev MeSH
biologické markery krev MeSH
dítě MeSH
dospělí MeSH
epilepsie temporálního laloku komplikace diagnostické zobrazování imunologie chirurgie MeSH
lidé středního věku MeSH
lidé MeSH
magnetická rezonanční tomografie MeSH
mladiství MeSH
mladý dospělý MeSH
mozek diagnostické zobrazování imunologie patologie chirurgie MeSH
následné studie MeSH
prognóza MeSH
průzkumy a dotazníky MeSH
refrakterní epilepsie komplikace diagnostické zobrazování imunologie chirurgie MeSH
retrospektivní studie MeSH
výsledek terapie MeSH
Check Tag
dítě MeSH
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
multicentrická studie MeSH
práce podpořená grantem MeSH
Research Support, N.I.H., Extramural MeSH
Geografické názvy
Evropa MeSH
Spojené státy americké MeSH

Článek

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Cancer cell. 2017 ; 31 (6) : 737-754.e6.

Cancer Cell
ISSN 1878-3686
Medvik
Zdroj

While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.

MeSH
genomika MeSH
individualizovaná medicína * MeSH
kohortové studie MeSH
lidé MeSH
meduloblastom klasifikace genetika terapie MeSH
metylace DNA MeSH
shluková analýza MeSH
stanovení celkové genové exprese MeSH
variabilita počtu kopií segmentů DNA MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH

Článek

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

The New England journal of medicine. 2017 ; 377 (17) : 1648-1656.

N Engl J Med
ISSN 1533-4406
Medvik
Zdroj

BACKGROUND: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. METHODS: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). RESULTS: The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients. CONCLUSIONS: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.).

MeSH
databáze jako téma MeSH
dítě MeSH
dospělí MeSH
epilepsie etiologie patologie chirurgie MeSH
hipokampus patologie MeSH
lidé MeSH
malformace mozkové kůry komplikace patologie MeSH
mozek patologie MeSH
nádory mozku komplikace patologie MeSH
spánkový lalok patologie MeSH
věk při počátku nemoci MeSH
věkové faktory MeSH
Check Tag
dítě MeSH
dospělí MeSH
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
Geografické názvy
Evropa MeSH

Článek

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

Lancet oncology. 2016 ; 17 (4) : 484-95. [pub] 20160312

Lancet Oncol.
ISSN 1474-5488
Medvik
Zdroj

BACKGROUND: Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific manner. METHODS: We retrospectively identified patients who had a histological diagnosis of medulloblastoma and complete data about extent of resection and survival from centres participating in the Medulloblastoma Advanced Genomics International Consortium. We collected from resections done between April, 1997, and February, 2013, at 35 international institutions. We established medulloblastoma subgroup affiliation by gene expression profiling on frozen or formalin-fixed paraffin-embedded tissues. We classified extent of resection on the basis of postoperative imaging as gross total resection (no residual tumour), near-total resection (<1·5 cm(2) tumour remaining), or sub-total resection (≥1·5 cm(2) tumour remaining). We did multivariable analyses of overall survival and progression-free survival using the variables molecular subgroup (WNT, SHH, group 4, and group 3), age (<3 vs ≥3 years old), metastatic status (metastases vs no metastases), geographical location of therapy (North America/Australia vs rest of the world), receipt of chemotherapy (yes vs no) and receipt of craniospinal irradiation (<30 Gy or >30 Gy vs no craniospinal irradiation). The primary analysis outcome was the effect of extent of resection by molecular subgroup and the effects of other clinical variables on overall and progression-free survival. FINDINGS: We included 787 patients with medulloblastoma (86 with WNT tumours, 242 with SHH tumours, 163 with group 3 tumours, and 296 with group 4 tumours) in our multivariable Cox models of progression-free and overall survival. We found that the prognostic benefit of increased extent of resection for patients with medulloblastoma is attenuated after molecular subgroup affiliation is taken into account. We identified a progression-free survival benefit for gross total resection over sub-total resection (hazard ratio [HR] 1·45, 95% CI 1·07-1·96, p=0·16) but no overall survival benefit (HR 1·23, 0·87-1·72, p=0·24). We saw no progression-free survival or overall survival benefit for gross total resection compared with near-total resection (HR 1·05, 0·71-1·53, p=0·8158 for progression-free survival and HR 1·14, 0·75-1·72, p=0·55 for overall survival). No significant survival benefit existed for greater extent of resection for patients with WNT, SHH, or group 3 tumours (HR 1·03, 0·67-1·58, p=0·89 for sub-total resection vs gross total resection). For patients with group 4 tumours, gross total resection conferred a benefit to progression-free survival compared with sub-total resection (HR 1·97, 1·22-3·17, p=0·0056), especially for those with metastatic disease (HR 2·22, 1·00-4·93, p=0·050). However, gross total resection had no effect on overall survival compared with sub-total resection in patients with group 4 tumours (HR 1·67, 0·93-2·99, p=0·084). INTERPRETATION: The prognostic benefit of increased extent of resection for patients with medulloblastoma is attenuated after molecular subgroup affiliation is taken into account. Although maximum safe surgical resection should remain the standard of care, surgical removal of small residual portions of medulloblastoma is not recommended when the likelihood of neurological morbidity is high because there is no definitive benefit to gross total resection compared with near-total resection. FUNDING: Canadian Cancer Society Research Institute, Terry Fox Research Institute, Canadian Institutes of Health Research, National Institutes of Health, Pediatric Brain Tumor Foundation, and the Garron Family Chair in Childhood Cancer Research.

MeSH
dítě MeSH
dospělí MeSH
kojenec MeSH
kombinovaná terapie MeSH
lidé MeSH
magnetická rezonanční tomografie MeSH
meduloblastom klasifikace genetika patologie chirurgie MeSH
nádory mozku klasifikace genetika patologie chirurgie MeSH
předškolní dítě MeSH
přežití po terapii bez příznaků nemoci MeSH
prognóza * MeSH
progrese nemoci MeSH
retrospektivní studie MeSH
Check Tag
dítě MeSH
dospělí MeSH
kojenec MeSH
lidé MeSH
mužské pohlaví MeSH
předškolní dítě MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
Geografické názvy
Kanada MeSH

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