We have recently demonstrated that a high-fat load can induce immediate increase in hepatic fat content (HFC) and that such an effect can be modified differently by co-administration of fructose or glucose in healthy subjects. Therefore, we addressed the question how consumption of these nutrients affects changes in HFC in subjects with non-alcoholic fatty liver disease (NAFLD). Eight male non-obese non-diabetic patients with NAFLD underwent 6 experiments each lasting 8 hours: 1. fasting, 2. high-fat load (150 g of fat (dairy cream) at time 0), 3. glucose (three doses of 50 g at 0, 2, and 4 hours), 4. high-fat load with three doses of 50 g of glucose, 5. fructose (three doses of 50 g at 0, 2, and 4 hours), 6. high-fat load with three doses of 50 g of fructose. HFC was measured using magnetic resonance spectroscopy prior to meal administration and 3 and 6 hours later. Plasma triglycerides, non-esterified fatty acids, glucose and insulin were monitored throughout each experiment. HFC increased by 10.4 ± 6.9% six hours after a high-fat load and by 15.2 ± 12.5% after high-fat load with fructose. When co-administering glucose with fat, HFC rose only transiently to return to baseline at 6 hours. Importantly, NAFLD subjects accumulated almost five times more fat in their livers than healthy subjects with normal HFC. Consumption of a high-fat load results in fat accumulation in the liver of NAFLD patients. Fat accumulation after a fat load is diminished by glucose but not fructose co-administration.
- MeSH
- dieta s vysokým obsahem tuků škodlivé účinky MeSH
- fruktosa aplikace a dávkování metabolismus MeSH
- glukosa aplikace a dávkování metabolismus MeSH
- inzulin krev MeSH
- játra metabolismus patofyziologie MeSH
- krevní glukóza analýza MeSH
- kyseliny mastné neesterifikované krev MeSH
- lidé MeSH
- magnetická rezonanční spektroskopie MeSH
- nealkoholová steatóza jater patofyziologie MeSH
- triglyceridy krev MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
- srovnávací studie MeSH
The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) with regard to immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised of a collection of disorders characterized by IgG4 hypergammaglobulinemia, the presence of IgG4-positive plasma cells in organs affected with fibrotic or sclerotizing changes and typical histopathological features. It was identified as a possible cause of vasculitis in large vessels. Studies have been published on a possible association between inflammatory aortic or cardiovascular disease and IgG4-RD. We examined 114 patients with AAA requiring surgery in order to identify findings which are characteristic of IgG4-RD. Aneurysm samples from seven patients showed histopathological features consistent with IgG4-RD and the presence of IgG4+ plasma cells. Only two of these seven patients showed elevated IgG4 serum levels higher 1·35 g/l. In five of the patients, the concentration of serum IgG4 was lower than 1·20 g/l, with the number of IgG4+ plasma cells being higher than 50/high-power field. These findings were consistent with AAA being a heterogeneous group of inflammatory diseases with different pathogenesis.
- MeSH
- aneurysma břišní aorty krev imunologie patologie MeSH
- aorta imunologie metabolismus patologie MeSH
- hypergamaglobulinemie krev imunologie patologie MeSH
- IgG4 asociovaná nemoc krev imunologie patologie MeSH
- imunoglobulin G krev imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- plazmatické buňky imunologie metabolismus patologie MeSH
- retrospektivní studie MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- práce podpořená grantem MeSH
After two days of an intensive roofing work, a healthy professional 41-year-old roofer experienced an isolated spontaneous dissection of the external iliac artery with an acute severe ischemia of the left lower extremity. The compressed true lumen, complete thrombosis of the false lumen and an overlapping dissection at the origin of the deep femoral artery necessitated an open surgery. An urgent iliofemoral bypass was constructed and external iliac artery was excluded. Connective tissue disorders were excluded by immunology, histology and genetic tests. Spontaneous dissection of the iliac artery has frequently been described in sportsmen after an exceptional physical strain. The same mechanism may also come into question following occupational overexertion. However, connective tissue or vascular wall disorders must be taken into consideration in differential diagnosis (Fig. 1, Ref. 21).
- MeSH
- arteria iliaca radiografie chirurgie MeSH
- disekce aorty etiologie radiografie chirurgie MeSH
- dospělí MeSH
- lidé MeSH
- zaměstnání MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- MeSH
- dlahy trendy využití MeSH
- fraktury femuru chirurgie komplikace terapie MeSH
- intramedulární fixace fraktury metody MeSH
- lidé MeSH
- protézy a implantáty využití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- srovnávací studie MeSH
