Myocardial infarction (MI) is the leading cause of death in industrialized countries. All the traditional risk factors for MI are responsible for approximately 50% of cases of MI cases. Attention therefore has recently focused on genetic variants that are not associated with conventional risk factors. One of them is the marker rs6922269, which has been suggested as a risk factor for development of MI in Western populations. We analyzed the relationship between rs6922269 variant on MTHFD1L gene and (i) risk of the acute coronary syndrome (ACS) in the Czech population and (ii) mortality in 7 years follow up. Rs6922269 (G>A) variant was analyzed (CR 99.3% for patients and 98.0% for controls) by PCR-RFLP in consecutively examined 1614 men and 503 women with ACS (age below 65 years) and in population-based controls--1191 men and 1368 women (aged up to 65 years). ANOVA and Chi square were used for statistical analysis. The genotype frequencies were almost identical (P=0.87) in the ACS patients and in controls and no differences were observed, if males (P=0.73) and females (P=0.93) were analysed separately. In addition, rs6922269 polymorphism was not associated with the classical risk factors (dyslipidemia, hypertension, obesity, smoking, diabetes) in control population. Cardiovascular mortality was significantly higher in males, carriers of the AA genotype (P<0.001, OR 2.52, 95% CI 1.40-4.55, for AA vs. +G). We conclude, that rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS.
- MeSH
- Acute Coronary Syndrome genetics mortality MeSH
- Aminohydrolases genetics MeSH
- Adult MeSH
- Formate-Tetrahydrofolate Ligase genetics MeSH
- Myocardial Infarction epidemiology genetics mortality MeSH
- Polymorphism, Single Nucleotide * MeSH
- Middle Aged MeSH
- Humans MeSH
- Methylenetetrahydrofolate Dehydrogenase (NADP) genetics MeSH
- Multienzyme Complexes genetics MeSH
- Polymorphism, Restriction Fragment Length MeSH
- Risk Factors MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Publication type
- Meeting Abstract MeSH
- MeSH
- Myocardial Infarction enzymology MeSH
- Interleukin-10 analysis genetics MeSH
- Humans MeSH
- Lipopolysaccharide Receptors analysis genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Congress MeSH
- MeSH
- Adult MeSH
- Cardiac Surgical Procedures MeSH
- Humans MeSH
- Heart Valve Diseases pathology therapy MeSH
- Postoperative Complications pathology therapy MeSH
- Arrhythmias, Cardiac pathology MeSH
- Heart Transplantation MeSH
- Heart Defects, Congenital surgery pathology therapy MeSH
- Patient Selection MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- MeSH
- Adult MeSH
- Endotoxins pharmacology MeSH
- Gram-Negative Bacterial Infections immunology complications MeSH
- Myocardial Infarction etiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipopolysaccharide Receptors genetics MeSH
- Monocytes physiology drug effects MeSH
- Polymorphism, Genetic MeSH
- Risk Factors MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- MeSH
- Hemodynamics physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Mitral Valve MeSH
- Papillary Muscles injuries MeSH
- Heart Rupture, Post-Infarction therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
