- MeSH
- diagnostické techniky a postupy MeSH
- diferenciální diagnóza MeSH
- financování organizované MeSH
- ischemie diagnóza etiologie komplikace MeSH
- klinický obraz nemoci MeSH
- kožní manifestace MeSH
- lidé MeSH
- livedo reticularis MeSH
- mezioborová komunikace MeSH
- mikrocirkulace imunologie MeSH
- pilotní projekty MeSH
- Raynaudova nemoc diagnóza etiologie MeSH
- retrospektivní studie MeSH
- statistika jako téma MeSH
- vaskulitida diagnóza etiologie klasifikace MeSH
- Check Tag
- lidé MeSH
The purpose of this study was to determine the different levels of copper and zinc in the serum, urine, and scalp hair of patients with Wilson's disease receiving different, currently accepted methods of treatment to reduce the copper load (penicillamine-group 1, n = 8; zinc-group 2, n = 8; penicillamine+zinc-group 3, n = 8). Blood, urine, and hair samples were collected from the patients. All three treatments resulted in a significant decrease of the serum copper levels. Significantly increased levels of zinc in the serum were detected in the patients in groups 2 and 3 (19.1 and 18.8 micromol/l, respectively; p < 0.05). Copper excretion in the urine significantly increased during its administration to groups 1 and 3 (11.5 and 7.94 micromol/24 h respectively; p < 0.001) due to the effect of penicillamine. The administration of zinc as monotherapy (group 2) or in combination with penicillamine (group 3) led to an increase of its excretion (25.3 and 22.4 micromol/24 h, respectively; p < 0.01). Only an insignificant rise of the copper content in the hair was found in all three groups of patients. The content of zinc in the hair did not differ significantly in any of the groups in comparison with the control group.
- MeSH
- dospělí MeSH
- hepatolentikulární degenerace krev farmakoterapie moč MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- měď analýza krev moč MeSH
- mladiství MeSH
- penicilamin terapeutické užití MeSH
- studie případů a kontrol MeSH
- vlasy, chlupy metabolismus MeSH
- zinek analýza krev terapeutické užití moč MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
