Mosquitoes are known to be vectors of numerous diseases leading to human morbidity and mortality at large scale in the world. Insecticide resistance has become a serious concern in controlling the insect vectors of public health importance. Dimethoate is an organophosphate insecticide used to control different insect pests including mosquitoes. Biological parameters of susceptible, unselected, and dimethoate-selected strains of Culex quinquefasciatus Say were studied in the laboratory to recognize resistance development potential and associated fitness cost. The dimethoate-selected strain showed 66.48-fold resistance to dimethoate compared with the susceptible strain after three continuous selections of generations. Realized heritability estimates of dimethoate resistance in Cx. quinquefasciatus yielded a value of 0.19. In dimethoate-selected strain, the biological traits including larval weight, survival from first instar to pupae, fecundity, number of next-generation larvae, relative fitness, net reproductive rate, intrinsic rate of natural increase, and biotic potential were significantly reduced as compared with the unselected strain. However, adult longevity, mean relative growth rate, weight of egg raft, female ratio, pupal duration, and emergence rate of the dimethoate-selected strain did not differ significantly compared with that of the unselected strain. This study provides useful information to devise retrospective management strategy for dimethoate resistance in Cx. quinquefasciatus.
- MeSH
- Culex drug effects genetics growth & development MeSH
- Heredity * MeSH
- Dimethoate pharmacology MeSH
- Genetic Fitness * MeSH
- Insecticides pharmacology MeSH
- Pupa drug effects genetics growth & development MeSH
- Larva drug effects genetics growth & development MeSH
- Insecticide Resistance * MeSH
- Selection, Genetic * MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- MeSH
- Acetylcholine chemistry MeSH
- Atropine therapeutic use MeSH
- Cholinesterase Inhibitors adverse effects toxicity MeSH
- Disinfection utilization MeSH
- Diazepam therapeutic use MeSH
- Dimethoate chemistry adverse effects toxicity MeSH
- Chlorpyrifos chemistry adverse effects toxicity MeSH
- European Union MeSH
- Fenitrothion chemistry adverse effects toxicity MeSH
- Humans MeSH
- Organophosphates history chemistry toxicity MeSH
- Organothiophosphorus Compounds chemistry adverse effects toxicity MeSH
- Poisoning diagnosis therapy MeSH
- Pesticides standards adverse effects toxicity MeSH
- Signs and Symptoms MeSH
- Cholinesterase Reactivators therapeutic use MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
- Geographicals
- Czech Republic MeSH
- Keywords
- BY-58 EC (BETERFELD, SRN),
- MeSH
- Dimethoate immunology toxicity MeSH
- Rats MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
Environmental health criteria. 90, ISSN 0250-863X
85 s. il.
- Conspectus
- Veřejné zdraví a hygiena
- NML Fields
- toxikologie
- environmentální vědy
- NML Publication type
- publikace WHO
Health and Safety Guide, ISSN 0259-7268 No. 20
40 s. : tab., lit.
- Conspectus
- Chemie. Mineralogické vědy
- NML Fields
- chemie, klinická chemie
- toxikologie
- NML Publication type
- publikace WHO
