Medical abzymology has made a great contribution to the development of general autoimmunity theory: it has put the autoantibodies (Ab) as the key brick of the theory to the level of physiological functionality by providing such Ab with the ability to catalyze and mediate direct and independent cytotoxic effect on cellular and molecular targets. Natural catalytic autoantibodies (abzymes) while being a pool of canonical Abs and possessing catalytic activity belong to the new group of physiologically active substances whose features and properties are evolutionary consolidated in one functionally active biomolecule. Therefore, further studies on Ab-mediated autoAg degradation and other targeted Ab-mediated proteolysis may provide biomarkers of newer generations and thus a supplementary tool for assessing the disease progression and predicting disability of the patients and persons at risks. This chapter is a summary of current knowledge and prognostic perspectives toward catalytic Abs in autoimmunity and thus some autoimmune clinical cases, their role in pathogenesis, and the exploitation of both whole molecules and their constituent parts in developing highly effective targeted drugs of the future to come, and thus the therapeutic protocols being individualized.

• MeSH
• autoimunita * MeSH
• autoprotilátky metabolismus   MeSH
• biologické markery MeSH
• katalytické protilátky * metabolismus   MeSH
• lidé MeSH
• progrese nemoci MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• hapteny diagnostické užití   MeSH
• imunohistochemie metody   využití   MeSH
• katalytické protilátky aplikace a dávkování   MeSH
• Publikační typ
• abstrakt z konference MeSH

The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.

• MeSH
• chemické jevy MeSH
• chemie fyzikální MeSH
• genetické matrice MeSH
• hapteny chemie   metabolismus   MeSH
• imunoglobuliny - Fab fragmenty chemie   metabolismus   MeSH
• katalytické protilátky chemie   genetika   metabolismus   MeSH
• katalýza MeSH
• konformace proteinů MeSH
• krystalografie rentgenová MeSH
• ligandy MeSH
• molekulární evoluce * MeSH
• molekulární modely MeSH
• mutace MeSH
• progesteron imunologie   MeSH
• rozpustnost MeSH
• teplota MeSH
• vazebná místa protilátek MeSH
• vodíková vazba MeSH
• Publikační typ
• časopisecké články MeSH
• Research Support, U.S. Gov't, Non-P.H.S. MeSH
• Research Support, U.S. Gov't, P.H.S. MeSH

Příprava diagnostické metody pro monitorování rozpadu chrupavky u kloubních chorob. XXX XXX XXX

• MeSH
• katalytické protilátky MeSH
• keratansulfát krev   MeSH
• kloubní chrupavka patologie   MeSH
• nemoci chrupavky diagnóza   MeSH
• proteoglykany krev   MeSH
• revmatické nemoci diagnóza   MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• revmatologie
• NLK Publikační typ
• závěrečné zprávy o řešení grantu IGA MZ ČR