Infertility is a relevant late-effect following cancer treatment; yet, a large proportion of survivors cannot recall having been informed of this risk. In an intervention study, we examined if and how supportive patient information material on fertility/fertility-preserving measures influences utilization of cryopreservation in adolescent cancer patients. The control group, recruited 03/2014-01/2016, received the usual patient education at initial diagnosis. The intervention group, recruited 04/2016-10/2017, received patient education supported by a fertility flyer and brochure. Patients and parents were each asked questions on utilization of cryopreservation in a questionnaire 3 and 6 months after initial diagnosis. Patient core and therapy data were obtained from medical records. Overall, cryopreservation rates showed no significant difference between the control (32.7%, n = 37/113) and intervention group (36.6%, n = 37/101). In the control group, cryopreservation was associated with gender (OR 0.100, CI 0.023-0.427), age (OR 1.559, CI 1.077-2.258) and recalling information on fertility protection (OR 33.663, CI 2.100-539.574); in the intervention group, cryopreservation was related to gender (OR 0.093, CI 0.026-0.330) and the estimated infertility risk (OR 43.665, CI 2.157-883.974).Conclusion: Cryopreservation rates did not overall increase following the intervention; however, the individual risk seemed to be brought into attention more: Those at risk, including younger patients, cryopreserved at higher rates.What is Known:•Infertility is a relevant late-effect following adolescent cancer.•Guidelines recommend to offer fertility protection before cancer treatment.•A relevant proportion of adolescents with cancer are not aware of this risk.•Fertility protection seems under-used in cancer patients at risk for infertility.What is New:•Information material on fertility and protection in adolescents did not increase overall rates of cryopreservation.•Cryopreservation rates were improved according to individual risk for infertility.•Our flyers and brochures on fertility in cancer patients are available in various languages.

• MeSH
• Outcome Assessment, Health Care MeSH
• Cryopreservation * statistics & numerical data   MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Neoplasms psychology   therapy   MeSH
• Follow-Up Studies MeSH
• Patient Acceptance of Health Care * psychology   statistics & numerical data   MeSH
• Risk MeSH
• Patient Education as Topic methods   MeSH
• Fertility Preservation * psychology   statistics & numerical data   MeSH
• Germ Cells * MeSH
• Check Tag
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Clinical Trial MeSH
• Geographicals
• Europe MeSH

• MeSH
• Reproductive Techniques, Assisted MeSH
• Fertility * physiology   genetics   MeSH
• Data Interpretation, Statistical MeSH
• Humans MeSH
• Mutation MeSH
• Reproductive Behavior classification   statistics & numerical data   MeSH
• Reproductive Health classification   statistics & numerical data   trends   MeSH
• Vital Statistics MeSH
• Age Factors * MeSH
• Fertility Preservation classification   statistics & numerical data   trends   MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Female MeSH